Anti-BTD antibody (ab166934)
Key features and details
- Goat polyclonal to BTD
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
Overview
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Product name
Anti-BTD antibody
See all BTD primary antibodies -
Description
Goat polyclonal to BTD -
Host species
Goat -
Tested applications
Suitable for: WBmore details -
Species reactivity
Reacts with: Human
Predicted to work with: Mouse, Rat -
Immunogen
Synthetic peptide, corresponding to internal sequence amino acids 372-385 of Human BTD (NP_000051.1).
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Positive control
- Human Liver lysates.
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
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Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles. -
Storage buffer
pH: 7.30
Preservative: 0.02% Sodium azide
Constituents: 99% Tris buffered saline, 0.5% BSA -
Concentration information loading...
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Purity
Immunogen affinity purified -
Purification notes
ab166934 is purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
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Recombinant Protein
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab166934 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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WB |
Use a concentration of 0.5 - 1.5 µg/ml. Predicted molecular weight: 61 kDa.
1 hour primary incubation is recommended for this product. |
Notes |
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WB
Use a concentration of 0.5 - 1.5 µg/ml. Predicted molecular weight: 61 kDa. 1 hour primary incubation is recommended for this product. |
Target
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Function
Catalytic release of biotin from biocytin, the product of biotin-dependent carboxylases degradation. -
Involvement in disease
Defects in BTD are the cause of biotinidase deficiency (BTD deficiency) [MIM:253260]; also called late-onset multiple carboxylase deficiency. BTD deficiency is a juvenile form of multiple carboxylase deficiency, an autosomal recessive disorder of biotin metabolism, characterized by ketoacidosis, hyperammonemia, excretion of abnormal organic acid metabolites, and dermatitis. BTD deficiency is characterized by seizures, hypotonia, skin rash, alopecia, ataxia, hearing loss, and optic atrophy. If untreated, symptoms usually become progressively worse, and coma and death may occur. -
Sequence similarities
Belongs to the CN hydrolase family. BTD/VNN subfamily.
Contains 1 CN hydrolase domain. -
Cellular localization
Secreted > extracellular space. - Information by UniProt
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Database links
- Entrez Gene: 686 Human
- Entrez Gene: 26363 Mouse
- Entrez Gene: 306262 Rat
- Omim: 609019 Human
- SwissProt: P43251 Human
- SwissProt: Q8CIF4 Mouse
- SwissProt: Q5FVF9 Rat
- Unigene: 517830 Human
see all -
Alternative names
- Biotinase antibody
- Biotinidase antibody
- Btd antibody
see all
Images
Datasheets and documents
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Datasheet download
References (0)
ab166934 has not yet been referenced specifically in any publications.