Overview

  • Product name

  • Description

    Sheep polyclonal to BTNL2
  • Host species

    Sheep
  • Specificity

    The IgG fraction of immunized serum was purified by antigen affinity chromatography and lyophilized from a 0.2 µm filtered solution in phosphate-buffered saline (PBS).
  • Tested applications

    Suitable for: WBmore details
  • Species reactivity

    Reacts with: Mouse
    Predicted to work with: Rat
  • Immunogen

    Recombinant fragment corresponding to Mouse BTNL2 aa 27-452. Mouse myeloma cell line NS0-derived
    Sequence:

    DDFR VVGPNLPILA KVGEDALLTC QLLPKRTTAH MEVRWYRSDP DMPVIMYRDG AEVTGLPMEG YGGRAEWMED STEEGSVALK IRQVQPSDDG QYWCRFQEGD YWRETSVLLQ VAALGSSPNI HVEGLGEGEV QLVCTSRGWF PEPEVHWEGI WGEKLMSFSE NHVPGEDGLF YVEDTLMVRN DSVETISCFI YSHGLRETQE ATIALSERLQ TELASVSVIG HSQPSPVQVG ENIELTCHLS PQTDAQNLEV RWLRSRYYPA VHVYANGTHV AGEQMVEYKG RTSLVTDAIH EGKLTLQIHN ARTSDEGQYR CLFGKDGVYQ EARVDVQVMA VGSTPRITRE VLKDGGMQLR CTSDGWFPRP HVQWRDRDGK TMPSFSEAFQ QGSQELFQVE TLLLVTNGSM VNVTCSISLP LGQEKTARFP LS


    Database link: O70355

  • Positive control

    • Lysates of mouse small intestine tissue

Properties

  • Form

    Lyophilised:Reconstitute the antibody with 100 uL sterile PBS and the final concentration is 500 ug/mL. Reconstituted antibody can also be aliquoted and stored frozen at < -20 °C for at least for six months without detectable loss of activity
  • Storage instructions

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
  • Storage buffer

    Constituent: PBS
  • Concentration information loading...
  • Purity

    Immunogen affinity purified
  • Clonality

    Polyclonal
  • Isotype

    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab215053 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1000 - 1/2000.

Target

  • Function

    Negative regulator of T cell proliferation.
  • Tissue specificity

    Expressed in brain, heart, kidney, liver, pancreas, ovary, leukocyte, small intestine, testis and thymus.
  • Involvement in disease

    Genetic variation in BTNL2 is a cause of susceptibility to sarcoidosis type 2 (SS2) [MIM:612387]. Sarcoidosis is an idiopathic, systemic, inflammatory disease characterized by the formation of immune granulomas in involved organs. Granulomas predominantly invade the lungs and the lymphatic system, but also skin, liver, spleen, eyes and other organs may be involved. Note=A nucleotide transition affecting a splice donor site results in the use of an alternative splice site and the production of isoform 3. Individuals expressing isoform 3 have a higher risk for sarcoidosis.
  • Sequence similarities

    Belongs to the immunoglobulin superfamily. BTN/MOG family.
    Contains 3 Ig-like V-type (immunoglobulin-like) domains.
  • Cellular localization

    Membrane. Isoform 2 is present in the nuclear, vesicle and plasma membranes, isoform 3 is found in cytoplasmic vesicle structures and is not membrane bound.
  • Information by UniProt
  • Database links

  • Alternative names

    • BTL-II antibody
    • Btnl2 antibody
    • BTNL2_HUMAN antibody
    • Butyrophilin like 2 (MHC class II associated) antibody
    • Butyrophilin-like protein 2 antibody
    • DAAP-282D22.2 antibody
    • HSBLMHC1 antibody
    • SS2 antibody
    see all

Images

  • Anti-BTNL2 antibody (ab215053) at 1/1000 dilution + lysates from mouse small intestine tissue

References

ab215053 has not yet been referenced specifically in any publications.

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