Recombinant
RabMAb

Recombinant Anti-BTNL2 antibody [EPR12252] (ab181198)

Overview

  • Product name

    Anti-BTNL2 antibody [EPR12252]
    See all BTNL2 primary antibodies
  • Description

    Rabbit monoclonal [EPR12252] to BTNL2
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WBmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Recombinant fragment within Human BTNL2 aa 200-400. The exact sequence is proprietary.
    Database link: Q9UIR0

  • Positive control

    • Human spleen, tonsil, small intestine tissue lysates, K562 cell lysate.
  • General notes

     

     

    Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMab® patents.

    This product is a recombinant rabbit monoclonal antibody.

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
  • Storage buffer

    Preservative: 0.01% Sodium azide
    Constituents: 59% PBS, 40% Glycerol, 0.05% BSA
  • Purity

    Tissue culture supernatant
  • Clonality

    Monoclonal
  • Clone number

    EPR12252
  • Isotype

    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab181198 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1000 - 1/10000. Detects a band of approximately 70 kDa (predicted molecular weight: 50 kDa).

Target

  • Function

    Negative regulator of T cell proliferation.
  • Tissue specificity

    Expressed in brain, heart, kidney, liver, pancreas, ovary, leukocyte, small intestine, testis and thymus.
  • Involvement in disease

    Genetic variation in BTNL2 is a cause of susceptibility to sarcoidosis type 2 (SS2) [MIM:612387]. Sarcoidosis is an idiopathic, systemic, inflammatory disease characterized by the formation of immune granulomas in involved organs. Granulomas predominantly invade the lungs and the lymphatic system, but also skin, liver, spleen, eyes and other organs may be involved. Note=A nucleotide transition affecting a splice donor site results in the use of an alternative splice site and the production of isoform 3. Individuals expressing isoform 3 have a higher risk for sarcoidosis.
  • Sequence similarities

    Belongs to the immunoglobulin superfamily. BTN/MOG family.
    Contains 3 Ig-like V-type (immunoglobulin-like) domains.
  • Cellular localization

    Membrane. Isoform 2 is present in the nuclear, vesicle and plasma membranes, isoform 3 is found in cytoplasmic vesicle structures and is not membrane bound.
  • Information by UniProt
  • Database links

  • Alternative names

    • BTL-II antibody
    • Btnl2 antibody
    • BTNL2_HUMAN antibody
    • Butyrophilin like 2 (MHC class II associated) antibody
    • Butyrophilin-like protein 2 antibody
    • DAAP-282D22.2 antibody
    • HSBLMHC1 antibody
    • SS2 antibody
    see all

Images

  • All lanes : Anti-BTNL2 antibody [EPR12252] (ab181198) at 1/2000 dilution

    Lane 1 : Human spleen tissue lysate
    Lane 2 : Human tonsil tissue lysate
    Lane 3 : Human small intestine tissue lysate
    Lane 4 : K562 cell lysate

    Lysates/proteins at 20 µg per lane.

    Secondary
    All lanes : Goat Anti-Rabbit IgG H&L (HRP) (ab136636) at 1/500 dilution

    Predicted band size: 50 kDa

References

ab181198 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab181198.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
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