BU 224 hydrochloride, Imidazoline I2 binding site allosteric modulator (ab146415)

Overview

  • Product name

    BU 224 hydrochloride, Imidazoline I2 binding site allosteric modulator
  • Description

    High affinity Imidazoline I2 binding site allosteric modulator
  • Biological description

    High affinity Imidazoline I2 binding site allosteric modulator (Ki = 2.1 nM). Dose-dependently inhibits C-fiber evoked responses, post-discharge and wind-up. Shows antinociceptive effects in vivo.
  • Purity

    > 99%
  • CAS Number

    205437-64-5
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    2-(4,5-Dihydro-1H-imidazol-2-yl)quinoline hydrochloride
  • Molecular weight

    233.70
  • Molecular formula

    C12H11N3.HCl
  • PubChem identifier

    11957470
  • Storage instructions

    Store at Room Temperature. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 10 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    C1CN=C(N1)C2=NC3=CC=CC=C3C=C2.Cl
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Garau C  et al. Chronic treatment with selective I2-imidazoline receptor ligands decreases the content of pro-apoptotic markers in rat brain. J Psychopharmacol 27:123-34 (2013). Read more (PubMed: 22719017) »
  • Thorn DA  et al. Effects of imidazoline I2 receptor ligands on morphine- and tramadol-induced antinociception in rats. Eur J Pharmacol 670:435-40 (2011). Read more (PubMed: 21970802) »
  • Diaz A  et al. BU-224 produces spinal antinociception as an agonist at imidazoline I2 receptors. Eur J Pharmacol 333:9-15 (1997). Read more (PubMed: 9311655) »

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