Budesonide, Glucocorticoid receptor binding affinity. Highly  IL-4 and IL-5 release inhibitor. (ab141279)

Overview

  • Product name

    Budesonide, Glucocorticoid receptor binding affinity. Highly  IL-4 and IL-5 release inhibitor.
  • Description

    Glucocorticoid receptor binding affinity. Highly potent IL-4 and IL-5 release inhibitor.
  • Biological description

    Glucocorticoid receptor binding affinity, stimulates transcription of target gene. Highly potent IL-4 and IL-5 release inhibitor (IC50 values are 320 and 220 pM, respectively). Potent concanavalin A-induced proliferation inhibitor (IC50 = 1.3 nM). Anti-asthmatic and anti-inflammatory agent. Orally active. Active in vivo and in vitro.
  • Purity

    > 98%
  • CAS Number

    51333-22-3
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    (11β,16α)-16,17-[Butylidenebis(oxy)]-11,21-dihydroxypregna-1,4-diene-3,20-dione
  • Molecular weight

    430.54
  • Molecular formula

    C25H34O6
  • PubChem identifier

    40000
  • Storage instructions

    Store at Room Temperature. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 100 mM and in ethanol to 50 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CCC[C@@H]1O[C@@H]2C[C@H]3[C@@H]4CCC5=CC(=O)C=C[C@@]5([C@H]4[C@H](C[C@@]3([C@@]2(O1)C(=O)CO)C)O)C
  • Source

    Synthetic

References

This product has been referenced in:

  • Stoeck M  et al. In vitro and in vivo anti-inflammatory activity of the new glucocorticoid ciclesonide. J Pharmacol Exp Ther 309:249-58 (2004). Read more (PubMed: 14718604) »
  • Spoelstra FM  et al. Additive anti-inflammatory effect of formoterol and budesonide on human lung fibroblasts. Thorax 57:237-41 (2002). Read more (PubMed: 11867828) »
  • Smith CL & Kreutner W In vitro glucocorticoid receptor binding and transcriptional activation by topically active glucocorticoids. Arzneimittelforschung 48:956-60 (1998). Read more (PubMed: 9793625) »

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