Overview

  • Product name

    Bufalin, Na+/K+-ATPase inhibitor
  • Description

    Selective Na+/K+-ATPase inhibitor. Potent steroid receptor coactivators SRC-3 and SRC-1 inhibitor.
  • Biological description

    Na+/K+-ATPase inhibitor. Potent steroid receptor coactivators SRC-3 and SRC-1 inhibitor. Induces cell differentiation and apoptosis. Activates AP-1 via JNK. Shows antitumor effects in vivo.
  • Purity

    > 98%
  • CAS Number

    465-21-4
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    5-[(3S,5R,8R,9S,10S,13R,14S,17R)-3,14-Dihydroxy-10,13-dimethyl-1,2,3,4,5,6,7,8,9,11,12,15,16,17-tetradecahydrocyclopenta[a]phenanthren-17-yl]pyran-2-one
  • Molecular weight

    386.52
  • Molecular formula

    C24H34O4
  • PubChem identifier

    9547215
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in ethanol to 50 mM (with warming) and in DMSO to 50 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Toxic, refer to SDS for further information.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    C[C@]12CC[C@@H](C[C@H]1CC[C@@H]3[C@@H]2CC[C@]4([C@@]3(CC[C@@H]4C5=COC(=O)C=C5)O)C)O
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Laursen M  et al. Structures and characterization of digoxin- and bufalin-bound Na+,K+-ATPase compared with the ouabain-bound complex. Proc Natl Acad Sci U S A 112:1755-60 (2015). Read more (PubMed: 25624492) »
  • Zhao L  et al. Bufalin inhibits TGF-ß-induced epithelial-to-mesenchymal transition and migration in human lung cancer A549 cells by downregulating TGF-ß receptors. Int J Mol Med : (2015). Read more (PubMed: 26133118) »
  • Wang Y  et al. Bufalin is a potent small-molecule inhibitor of the steroid receptor coactivators SRC-3 and SRC-1. Cancer Res 74:1506-17 (2014). Read more (PubMed: 24390736) »

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