Overview

  • Product name

    Bufexamac, HDAC6 and HDAC10 inhibitor NSAID
  • Description

    HDAC6 and HDAC10 inhibitor. NSAID.
  • Biological description

    HDAC6 and HDAC10 inhibitor. NSAID. COX inhibitor for IFN-α release (EC50 = 9 μM). Shows anti-inflammatory, analgesic, and antipyretic effects in vivo. Orally active.
  • Purity

    > 99%
  • CAS Number

    2438-72-4
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Bantscheff M  et al. Chemoproteomics profiling of HDAC inhibitors reveals selective targeting of HDAC complexes. Nat Biotechnol 29:255-65 (2011). Read more (PubMed: 21258344) »
  • Seto Y  et al. In vitro photobiochemical characterization of sulfobutylether-ß-cyclodextrin formulation of bufexamac. J Pharm Biomed Anal 55:591-6 (2011). Read more (PubMed: 21429689) »
  • Marttinen PH  et al. Changes in MMP-2 and -9 activity and MMP-8 reactivity after amphotericin B induced synovitis and treatment with bufexamac. J Vet Med A Physiol Pathol Clin Med 53:311-8 (2006). Read more (PubMed: 16901276) »

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