Bumetanide, Na+/2Cl-/K+ cotransporter inhibitor (ab142489)

Overview

  • Product name

    Bumetanide, Na+/2Cl-/K+ cotransporter inhibitor
  • Description

    Potent, selective Na+/2Cl-/K+ cotransporter inhibitor
  • Biological description

    Potent, selective Na+/2Cl-/K+ cotransporter inhibitor. Shows 40-fold greater potency than furosemide (Asc 314). Shows diuretic and anticonvulsant effects in vivo. Orally active.
  • Purity

    > 98%
  • CAS Number

    28395-03-1
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    3-(Butylamino)-4-phenoxy-5-sulfamoylbenzoic acid
  • Molecular weight

    364.42
  • Molecular formula

    C17H20N2O5S
  • PubChem identifier

    2471
  • Storage instructions

    Store at Room Temperature. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 50 mM and in ethanol to 25 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CCCCNC1=C(C(=CC(=C1)C(=O)O)S(=O)(=O)N)OC2=CC=CC=C2
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Glaser N  et al. Cerebral metabolic alterations in rats with diabetic ketoacidosis: effects of treatment with insulin and intravenous fluids and effects of bumetanide. Diabetes 59:702-9 (2010). Read more (PubMed: 20028943) »
  • Mares P Age- and dose-specific anticonvulsant action of bumetanide in immature rats. Physiol Res 58:927-30 (2009). Read more (PubMed: 20059292) »
  • Lee SH  et al. Pharmacokinetics and pharmacodynamics of bumetanide after intravenous and oral administration to rats: absorption from various GI segments. J Pharmacokinet Biopharm 22:1-17 (1994). Read more (PubMed: 8027946) »

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