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Cell Biology Cell Cycle Cell Cycle Inhibitors p53
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BVT 948, Protein tyrosine phosphatase (PTP) inhibitor (ab141304)

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Chemical Structure - BVT 948, Protein tyrosine phosphatase (PTP) inhibitor (ab141304)

    Key features and details

    • Non-competitive, irreversible protein tyrosine phosphatase (PTP) inhibitor
    • CAS Number: 39674-97-0
    • Purity: > 99%
    • Soluble in DMSO to 50 mM and in ethanol to 20 mM
    • Form / State: Solid
    • Source: Synthetic

    Overview

    • Product name

      BVT 948, Protein tyrosine phosphatase (PTP) inhibitor
    • Description

      Non-competitive, irreversible protein tyrosine phosphatase (PTP) inhibitor
    • Biological description

      Non-competitive, irreversible protein tyrosine phosphatase (PTP) inhibitor (IC50 values are 0.9 (PTP1B), 1.7 (TCPTP), 0.09 (SHP-2), 1.5 (LAR) and 0.7 (YopH) μM). Active in vivo and cell-permeable.

    • Purity

      > 99%
    • CAS Number

      39674-97-0
    • Chemical structure

      Chemical Structure

    Properties

    • Chemical name

      4-Hydroxy-3,3-dimethyl-2H-benz[g]indole-2,5(3H)-dione
    • Molecular weight

      241.25
    • Molecular formula

      C14H11NO3
    • PubChem identifier

      6604934
    • Storage instructions

      Store at -20°C. It is important to note that this product is reported to be light sensitive. Store In the Dark. Store under desiccating conditions.
    • Solubility overview

      Soluble in DMSO to 50 mM and in ethanol to 20 mM
    • Handling

      Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

      Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

    • SMILES

      OC=2C(=O)c1ccccc1C3=NC(=O)C(C)(C)C=23
    • Source

      Synthetic

    • Research areas

      • Cell Biology
      • Cell Cycle
      • Cell Cycle Inhibitors
      • p53
      • Cell Biology
      • Apoptosis
      • Intracellular
      • p53 Pathway
      • Neuroscience
      • Neurology process
      • Neurodegenerative disease
      • Alzheimer's disease
      • Tangles & Tau
      • Signal Transduction
      • Cytoskeleton / ECM
      • Cytoskeleton
      • Microtubules
      • MT Associated Proteins
      • Tau
      • Cardiovascular
      • Lipids / Lipoproteins
      • Lipid Metabolism
      • Cytochromes
      • Epigenetics and Nuclear Signaling
      • DNA / RNA
      • DNA Damage & Repair
      • Homologous Recomb.
      • Epigenetics and Nuclear Signaling
      • DNA / RNA
      • DNA Damage & Repair
      • Fanconi's Anemia
      • Epigenetics and Nuclear Signaling
      • DNA / RNA
      • DNA Damage & Repair
      • DNA Damage Response
      • p53
      • Epigenetics and Nuclear Signaling
      • DNA / RNA
      • DNA Synthesis
      • Topoisomerases
      • Epigenetics and Nuclear Signaling
      • Transcription
      • Domain Families
      • Zinc Finger
      • Cell Biology
      • Proteolysis / Ubiquitin
      • Proteasome / Ubiquitin
      • Deubiquitination
      • Cell Biology
      • Apoptosis
      • Intracellular
      • Caspases etc
      • Caspases
      • Signal Transduction
      • Protein Phosphorylation
      • Ser / Thr Phosphatases
      • Signal Transduction
      • Growth Factors/Hormones
      • Hormones
      • Neuroscience
      • Neurology process
      • Neurodegenerative disease
      • Other
      • Epigenetics and Nuclear Signaling
      • Transcription
      • Cancer susceptibility
      • Tumor Suppressors
      • Epigenetics and Nuclear Signaling
      • Nuclear Signaling Pathways
      • Nuclear Receptors
      • Corticoid
      • Signal Transduction
      • Signaling Pathway
      • Nuclear Signaling
      • Nuclear Hormone Receptors
      • Vitamin D Receptor
      • Epigenetics and Nuclear Signaling
      • Nuclear Signaling Pathways
      • Nuclear Receptors
      • Vitamin D Receptor
      • Epigenetics and Nuclear Signaling
      • Cell cycle
      • Cell Cycle Inhibitors
      • p53
      • Epigenetics and Nuclear Signaling
      • Transcription
      • Transcription Factors
      • Neuroscience
      • Cell Type Marker
      • Neuron marker
      • Axon marker
      • Signal Transduction
      • Metabolism
      • Drug metabolism
      • Signal Transduction
      • Metabolism
      • Alcohol metabolism
      • Cancer
      • Cell cycle
      • Cell cycle inhibitors
      • p53 pathway
      • Cancer
      • Invasion/microenvironment
      • Apoptosis
      • Caspases
      • Cancer
      • Signal transduction
      • Nuclear signaling
      • Nuclear hormone receptors
      • Other
      • Cancer
      • Oncoproteins/suppressors
      • Tumor suppressors
      • p53 pathway
      • Cancer
      • Cancer Metabolism
      • Response to hypoxia
      • Epigenetics and Nuclear Signaling
      • Ubiquitin & Ubiquitin Like Modifiers
      • Deubiquitination
      • Biochemicals
      • Chemical Type
      • Biochemicals
      • Biochemicals
      • Pharmacology
      • Enzymes
      • Phosphatase
      • Non-selective
      • Inhibitors
      • Metabolism
      • Pathways and Processes
      • Metabolic signaling pathways
      • Lipid and lipoprotein metabolism
      • Lipases
      • Metabolism
      • Pathways and Processes
      • Metabolic signaling pathways
      • Drug metabolism
      • Metabolism
      • Pathways and Processes
      • Metabolic signaling pathways
      • Alcohol metabolism
      • Metabolism
      • Pathways and Processes
      • Metabolism processes
      • Hypoxia
      • Metabolism
      • Pathways and Processes
      • Mitochondrial Metabolism
      • Cytochromes
      • Metabolism
      • Pathways and Processes
      • Metabolism processes
      • Apoptosis
      • Cancer
      • Cell Death
      • Apoptosis
      • Apoptosis Markers
      • Caspases
      • Cancer
      • Cell Death
      • Apoptosis
      • Metabolism

    Images

    • Chemical Structure - BVT 948, Protein tyrosine phosphatase (PTP) inhibitor (ab141304)
      Chemical Structure - BVT 948, Protein tyrosine phosphatase (PTP) inhibitor (ab141304)
      2D chemical structure image of ab141304, BVT 948, Protein tyrosine phosphatase (PTP) inhibitor

    Protocols

    To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

    Click here to view the general protocols

    Datasheets and documents

    • SDS download

    • Datasheet download

      Download
    • COA

    References (0)

    Publishing research using ab141304? Please let us know so that we can cite the reference in this datasheet.

    ab141304 has not yet been referenced specifically in any publications.

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