Overview

  • Product name

    BX 513 hydrochloride, CCR1 antagonist
  • Description

    Potent and selective CCR1 antagonist
  • Alternative names

    • VUF 2274
  • Biological description

    Potent and selective CCR1 antagonist (IC50 = 8.4 μM). Ki values are 0.04 nM (CCR1) and >10 nM (CCR5, CXCR2 and CXCR4). Displays inverse agonist activity for US28, a HCMV-encoded receptor. Able to produce concentration-dependent inhibition of MIP-1α and Ca2+ mobilization.
  • Purity

    > 99%
  • CAS Number

    1216540-18-9
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Di Prisco S  et al. RANTES-mediated control of excitatory amino acid release in mouse spinal cord. J Neurochem 121:428-37 (2012). Read more (PubMed: 22385043) »
  • Casarosa P  et al. Identification of the first nonpeptidergic inverse agonist for a constitutively active viral-encoded G protein-coupled receptor. J Biol Chem 278:5172-8 (2003). Read more (PubMed: 12456673) »
  • Hesselgesser J  et al. Identification and characterization of small molecule functional antagonists of the CCR1 chemokine receptor. J Biol Chem 273:15687-92 (1998). Read more (PubMed: 9624164) »

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