Overview

  • Product name

    BX-912, PDPK1 inhibitor
  • Description

    Potent and selective competitive PDPK1 inhibitor
  • Biological description

    Potent and selective competitive PDPK1 inhibitor. Induces apoptosis. Shows antiproliferative effects (IC50 = 320 nM, PC-3 cells). Inhibits anchorage-dependent growth in tumor cells.
  • Purity

    > 95%
  • CAS Number

    702674-56-4
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    N-(3-(4-(2-(1H-Imidazol-4-yl)ethylamino)-5-bromopyrimidin-2-ylamino)phenyl)pyrrolidine-1-carboxamide
  • Molecular weight

    471.35
  • Molecular formula

    C20H23BrN8O
  • PubChem identifier

    11754511
  • Storage instructions

    Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in ethanol to 100 mM and in DMSO to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    C1CCN(C1)C(=O)NC2=CC=CC(=C2)NC3=NC=C(C(=N3)NCCC4=CN=CN4)Br
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Dangelmaier C  et al. PDK1 selectively phosphorylates Thr(308) on Akt and contributes to human platelet functional responses. Thromb Haemost 111:508-17 (2014). Read more (PubMed: 24352480) »
  • Mashukova A  et al. PDK1 in apical signaling endosomes participates in the rescue of the polarity complex atypical PKC by intermediate filaments in intestinal epithelia. Mol Biol Cell 23:1664-74 (2012). Read more (PubMed: 22398726) »
  • Feldman RI  et al. Novel small molecule inhibitors of 3-phosphoinositide-dependent kinase-1. J Biol Chem 280:19867-74 (2005). Read more (PubMed: 15772071) »

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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