BYK 191023 dihydrochloride, iNOS inhibitor (ab146441)

Overview

  • Product name

    BYK 191023 dihydrochloride, iNOS inhibitor
  • Description

    Potent, selective irreversible iNOS inhibitor
  • Biological description

    Potent, selective irreversible iNOS inhibitor (IC50 values are 86, 17000, 162000 nM for iNOS, nNOS and eNOS respectively). Interacts with the catalytic center of the enzyme. Shows antihypotensive effects in vivo.
  • Purity

    > 99%
  • CAS Number

    1216722-25-6
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    2-[2-(4-Methoxy-2-pyridinyl)ethyl]-3H-imidazo[4,5-b]pyridine dihydrochloride
  • Molecular weight

    327.21
  • Molecular formula

    C14H14N4O.2HCl
  • PubChem identifier

    56972216
  • Storage instructions

    Store at +4°C.
  • Solubility overview

    Soluble in water to 100 mM
  • Handling

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    COc1ccnc(c1)CCc2[nH]c3cccnc3n2.Cl.Cl
  • Source

    Synthetic

References

This product has been referenced in:

  • Tiso M  et al. BYK191023 (2-[2-(4-methoxy-pyridin-2-yl)-ethyl]-3h-imidazo[4,5-b]pyridine) is an NADPH- and time-dependent irreversible inhibitor of inducible nitric-oxide synthase. Mol Pharmacol 73:1244-53 (2008). Read more (PubMed: 18178668) »
  • Strub A  et al. The novel imidazopyridine 2-[2-(4-methoxy-pyridin-2-yl)-ethyl]-3H-imidazo[4,5-b]pyridine (BYK191023) is a highly selective inhibitor of the inducible nitric-oxide synthase. Mol Pharmacol 69:328-37 (2006). Read more (PubMed: 16223957) »
  • Lehner MD  et al. In vivo characterization of the novel imidazopyridine BYK191023 [2-[2-(4-methoxy-pyridin-2-yl)-ethyl]-3H-imidazo[4,5-b]pyridine], a potent and highly selective inhibitor of inducible nitric-oxide synthase. J Pharmacol Exp Ther 317:181-7 (2006). Read more (PubMed: 16368897) »

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