Overview

  • Product name

    C 646, p300/CBP Inhibitor, p300/CBP HAT inhibitor
  • Description

    Cell-permeable, competitive, selective, potent p300/CBP HAT inhibitor
  • Biological description

    Cell-permeable, competitive, selective, potent p300/CBP histone acetyltransferase inhibitor (Ki = 400 nM). Blocks dynamic acetylation. Anticancer agent. Active in vitro and in vivo.
  • Purity

    > 98%
  • CAS Number

    328968-36-1
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Crump NT  et al. Dynamic acetylation of all lysine-4 trimethylated histone H3 is evolutionarily conserved and mediated by p300/CBP. Proc Natl Acad Sci U S A 108:7814-9 (2011). Read more (PubMed: 21518915) »
  • Marek R  et al. Paradoxical enhancement of fear extinction memory and synaptic plasticity by inhibition of the histone acetyltransferase p300. J Neurosci 31:7486-91 (2011). Read more (PubMed: 21593332) »
  • Bowers EM  et al. Virtual ligand screening of the p300/CBP histone acetyltransferase: identification of a selective small molecule inhibitor. Chem Biol 17:471-82 (2010). Read more (PubMed: 20534345) »
See all 3 Publications for this product

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