Recombinant
RabMAb

Recombinant Anti-c-Myc antibody [Y69] (ab32072)

Rabbit recombinant monoclonal c-Myc antibody [Y69]. Validated in WB, IP, IHC, Flow Cyt, ICC/IF and tested in Mouse, Rat, Human. Cited in 357 publication(s). Independently reviewed in 37 review(s).

Publishing research using ab32072? Please let us know so that we can cite the reference in this datasheet.

ab32072 has been referenced in 444 publications.

  • Luo Y  et al. Long non-coding RNA NEAT1 promotes colorectal cancer progression by competitively binding miR-34a with SIRT1 and enhancing the Wnt/ß-catenin signaling pathway. Cancer Lett 440-441:11-22 (2019). PubMed: 30312725
  • Aakko S  et al. MYC-Induced miR-203b-3p and miR-203a-3p Control Bcl-xL Expression and Paclitaxel Sensitivity in Tumor Cells. Transl Oncol 12:170-179 (2019). PubMed: 30359947
  • Tian X  et al. Utility of Combined EZH2, p-ERK1/2, p-STAT, and MYC Expression in the Differential Diagnosis of EZH2-positive Hodgkin Lymphomas and Related Large B-Cell Lymphomas. Am J Surg Pathol 43:102-109 (2019). PubMed: 30371509
  • Kim DU  et al. Phosphodiesterase 4B is an effective therapeutic target in colorectal cancer. Biochem Biophys Res Commun 508:825-831 (2019). PubMed: 30528730
  • Khan M  et al. Attenuation of Tumor Suppressive Function of FBXO16 Ubiquitin Ligase Activates Wnt Signaling In Glioblastoma. Neoplasia 21:106-116 (2019). PubMed: 30530053
  • Tan ZB  et al. Rheum palmatum extract exerts anti-hepatocellular carcinoma effects by inhibiting signal transducer and activator of transcription 3 signaling. J Ethnopharmacol 232:62-72 (2019). PubMed: 30553869
  • Zhang C  et al. HEF1 regulates differentiation through the Wnt5a/ß-catenin signaling pathway in human gastric cancer. Biochem Biophys Res Commun 509:201-208 (2019). PubMed: 30579603
  • Dudhwala ZM  et al. Active ß-Catenin Signaling in the Small Intestine of Humans During Infancy. Dig Dis Sci 64:76-83 (2019). PubMed: 30382540
  • Sun WL  et al. Long noncoding RNA OIP5-AS1 targets Wnt-7b to affect glioma progression via modulation of miR-410. Biosci Rep 39:N/A (2019). PubMed: 30498093
  • Fudhaili A  et al. Resveratrol epigenetically regulates the expression of zinc finger protein 36 in non-small cell lung cancer cell lines. Oncol Rep 41:1377-1386 (2019). PubMed: 30535453
  • Li S  et al. c-Myc induced upregulation of long non-coding RNA SNHG16 enhances progression and carcinogenesis in oral squamous cell carcinoma. Cancer Gene Ther N/A:N/A (2019). PubMed: 30607006
  • Santoro A  et al. p53 Loss in Breast Cancer Leads to Myc Activation, Increased Cell Plasticity, and Expression of a Mitotic Signature with Prognostic Value. Cell Rep 26:624-638.e8 (2019). PubMed: 30650356
  • Ji Q  et al. Hematopoietic PBX-interacting protein mediates cartilage degeneration during the pathogenesis of osteoarthritis. Nat Commun 10:313 (2019). PubMed: 30659184
  • Annunziato S  et al. Comparative oncogenomics identifies combinations of driver genes and drug targets in BRCA1-mutated breast cancer. Nat Commun 10:397 (2019). PubMed: 30674894
  • Sheng X  et al. IRE1a-XBP1s pathway promotes prostate cancer by activating c-MYC signaling. Nat Commun 10:323 (2019). PubMed: 30679434
  • Li Y  et al. Functional polymorphisms on chromosome 5p15.33 disturb telomere biology and confer the risk of non-small cell lung cancer in Chinese population. Mol Carcinog N/A:N/A (2019). PubMed: 30680798
  • Lee JS  et al. Loss of SLC25A11 causes suppression of NSCLC and melanoma tumor formation. EBioMedicine 40:184-197 (2019). PubMed: 30686754
  • Chen P  et al. 3-Hydroxyisoindolin-1-one derivates: Synthesis by palladium-catalyzed CH activation as BRD4 inhibitors against human acute myeloid leukemia (AML) cells. Bioorg Chem 86:119-125 (2019). PubMed: 30690335
  • Huang Y  et al. Small-Molecule Targeting of Oncogenic FTO Demethylase in Acute Myeloid Leukemia. Cancer Cell 35:677-691.e10 (2019). PubMed: 30991027
  • Zheng M  et al. CTHRC1 overexpression promotes cervical carcinoma progression by activating the Wnt/PCP signaling pathway. Oncol Rep 41:1531-1538 (2019). PubMed: 30628714
  • He J  et al. BCL2L10/BECN1 modulates hepatoma cells autophagy by regulating PI3K/AKT signaling pathway. Aging (Albany NY) 11:350-370 (2019). PubMed: 30696802
  • Tao H  et al. NFAT5 is Regulated by p53/miR-27a Signal Axis and Promotes Mouse Ovarian Granulosa Cells Proliferation. Int J Biol Sci 15:287-297 (2019). PubMed: 30745821
  • Han B  et al. PRSS23 knockdown inhibits gastric tumorigenesis through EIF2 signaling. Pharmacol Res 142:50-57 (2019). PubMed: 30769097
  • Zhou X  et al. Inhibition of MEK suppresses hepatocellular carcinoma growth through independent MYC and BIM regulation. Cell Oncol (Dordr) N/A:N/A (2019). WB, IHC-P ; Mouse . PubMed: 30788663
  • Coleman DJ  et al. Maintenance of MYC expression promotes de novo resistance to BET bromodomain inhibition in castration-resistant prostate cancer. Sci Rep 9:3823 (2019). PubMed: 30846826
  • Kido T  et al. The X-linked tumor suppressor TSPX downregulates cancer-drivers/oncogenes in prostate cancer in a C-terminal acidic domain dependent manner. Oncotarget 10:1491-1506 (2019). PubMed: 30863497
  • Kim DU  et al. Inhibition of phosphodiesterase 4D decreases the malignant properties of DLD-1 colorectal cancer cells by repressing the AKT/mTOR/Myc signaling pathway. Oncol Lett 17:3589-3598 (2019). PubMed: 30867802
  • Li T  et al. LINC00702/miR-4652-3p/ZEB1 axis promotes the progression of malignant meningioma through activating Wnt/ß-catenin pathway. Biomed Pharmacother 113:108718 (2019). PubMed: 30849635
  • Pillay N  et al. DNA Replication Vulnerabilities Render Ovarian Cancer Cells Sensitive to Poly(ADP-Ribose) Glycohydrolase Inhibitors. Cancer Cell 35:519-533.e8 (2019). PubMed: 30889383
  • Koga Y  et al. The role of FBXW7, a cell-cycle regulator, as a predictive marker of recurrence of gastrointestinal stromal tumors. Gastric Cancer N/A:N/A (2019). PubMed: 30854619
  • Muraki Y  et al. Induced Pluripotent Stem Cell-related Genes Correlate With Poor Prognoses of Oral Squamous Cell Carcinoma. Anticancer Res 39:1205-1216 (2019). PubMed: 30842151
  • Cristóbal I  et al. Deregulation of SET is Associated with Tumor Progression and Predicts Adverse Outcome in Patients with Early-Stage Colorectal Cancer. J Clin Med 8:N/A (2019). PubMed: 30871013
  • Wang Q  et al. Long noncoding RNA Linc02023 regulates PTEN stability and suppresses tumorigenesis of colorectal cancer in a PTEN-dependent pathway. Cancer Lett 451:68-78 (2019). PubMed: 30849479
  • Rantala R & Chaillou T Mild hypothermia affects the morphology and impairs glutamine-induced anabolic response in human primary myotubes. Am J Physiol Cell Physiol N/A:N/A (2019). PubMed: 30917033
  • Sun C  et al. URG11 promotes proliferation and induced apoptosis of LNCaP cells. Int J Mol Med 43:2075-2085 (2019). PubMed: 30864678
  • Guo X  et al. Long noncoding RNA HOTAIR knockdown inhibits autophagy and epithelial-mesenchymal transition through the Wnt signaling pathway in radioresistant human cervical cancer HeLa cells. J Cell Physiol 234:3478-3489 (2019). PubMed: 30367473
  • Yang Z  et al. The biological function of long noncoding RNA FAL1 in oesophageal carcinoma cells. Artif Cells Nanomed Biotechnol 47:896-903 (2019). PubMed: 30873881
  • Zhang HL  et al. c-Myc maintains the self-renewal and chemoresistance properties of colon cancer stem cells. Oncol Lett 17:4487-4493 (2019). PubMed: 30944638
  • Katsura Y  et al. A Novel Combination Cancer Therapy with Iron Chelator Targeting Cancer Stem Cells via Suppressing Stemness. Cancers (Basel) 11:N/A (2019). PubMed: 30717462
  • Goff LW  et al. Phase I study combining the aurora kinase a inhibitor alisertib with mFOLFOX in gastrointestinal cancer. Invest New Drugs 37:315-322 (2019). PubMed: 30191522
  • Moon SH  et al. p53 Represses the Mevalonate Pathway to Mediate Tumor Suppression. Cell 176:564-580.e19 (2019). PubMed: 30580964
  • Shimizu H  et al. Prevention of cancer dormancy by Fbxw7 ablation eradicates disseminated tumor cells. JCI Insight 4:N/A (2019). PubMed: 30830867
  • Sun Z & Liu JL mTOR-S6K1 pathway mediates cytoophidium assembly. J Genet Genomics 46:65-74 (2019). PubMed: 30857853
  • Xu L  et al. SIRT3 elicited an anti-Warburg effect through HIF1a/PDK1/PDHA1 to inhibit cholangiocarcinoma tumorigenesis. Cancer Med 8:2380-2391 (2019). PubMed: 30993888
  • Aaron-Brooks LM  et al. Hyperglycemia and T Cell infiltration are associated with stromal and epithelial prostatic hyperplasia in the nonobese diabetic mouse. Prostate 79:980-993 (2019). PubMed: 30999385
  • Sun K  et al. Tre2 (USP6NL) promotes colorectal cancer cell proliferation via Wnt/ß-catenin pathway. Cancer Cell Int 19:102 (2019). PubMed: 31015802
  • Hu J  et al. Cancer Stem Cell Marker Endoglin (CD105) Induces Epithelial Mesenchymal Transition (EMT) but Not Metastasis in Clear Cell Renal Cell Carcinoma. Stem Cells Int 2019:9060152 (2019). PubMed: 31015843
  • Yang J  et al. STAT1-induced upregulation of LINC00467 promotes the proliferation migration of lung adenocarcinoma cells by epigenetically silencing DKK1 to activate Wnt/ß-catenin signaling pathway. Biochem Biophys Res Commun N/A:N/A (2019). PubMed: 31027730
  • Liu T  et al. Epigenetically Down-Regulated Acetyltransferase PCAF Increases the Resistance of Colorectal Cancer to 5-Fluorouracil. Neoplasia 21:557-570 (2019). PubMed: 31042625
  • Weissmiller AM  et al. Inhibition of MYC by the SMARCB1 tumor suppressor. Nat Commun 10:2014 (2019). PubMed: 31043611
  • Wang G  et al. Intraductal fulvestrant for Therapy of ERa-positive Ductal Carcinoma in Situ (DCIS) of the breast- a Preclinical Study. Carcinogenesis N/A:N/A (2019). PubMed: 31046118
  • Watanabe K  et al. Emergence of the Dedifferentiated Phenotype in Hepatocyte-Derived Tumors in Mice: Roles of Oncogene-Induced Epigenetic Alterations. Hepatol Commun 3:697-715 (2019). PubMed: 31061957
  • Huang X  et al. Resveratrol Promotes Diabetic Wound Healing via SIRT1-FOXO1-c-Myc Signaling Pathway-Mediated Angiogenesis. Front Pharmacol 10:421 (2019). PubMed: 31068817
  • Pan Y  et al. Synergistic inhibition of pancreatic cancer with anti-PD-L1 and c-Myc inhibitor JQ1. Oncoimmunology 8:e1581529 (2019). PubMed: 31069140
  • Sun Y  et al. Restoration of miRNA-148a in pancreatic cancer reduces invasion and metastasis by inhibiting the Wnt/ß-catenin signaling pathway via downregulating maternally expressed gene-3. Exp Ther Med 17:639-648 (2019). PubMed: 30651845
  • Li X  et al. Knock-Down of HOXB8 Prohibits Proliferation and Migration of Colorectal Cancer Cells via Wnt/ß-Catenin Signaling Pathway. Med Sci Monit 25:711-720 (2019). PubMed: 30677006
  • Zhu H  et al. MicroRNA-488 inhibits endometrial glandular epithelial cell proliferation, migration, and invasion in endometriosis mice via Wnt by inhibiting FZD7. J Cell Mol Med 23:2419-2430 (2019). PubMed: 30729701
  • Li N  et al. MicroRNA-16 inhibits migration and invasion via regulation of the Wnt/ß-catenin signaling pathway in ovarian cancer. Oncol Lett 17:2631-2638 (2019). PubMed: 30854038
  • Xu L  et al. The SIRT2/cMYC Pathway Inhibits Peroxidation-Related Apoptosis In Cholangiocarcinoma Through Metabolic Reprogramming. Neoplasia 21:429-441 (2019). PubMed: 30933885
  • Fu XH  et al. CUDC-907 displays potent antitumor activity against human pancreatic adenocarcinoma in vitro and in vivo through inhibition of HDAC6 to downregulate c-Myc expression. Acta Pharmacol Sin 40:677-688 (2019). PubMed: 30224636
  • Peng W  et al. Type I? phosphatidylinositol phosphate kinase promotes tumor growth by facilitating Warburg effect in colorectal cancer. EBioMedicine 44:375-386 (2019). PubMed: 31105034
  • Ye Z & Ayer DE Ras Suppresses TXNIP Expression by Restricting Ribosome Translocation. Mol Cell Biol 38:N/A (2018). PubMed: 30037981
  • Wang S  et al. miR-124 regulates STAT3-mediated cell proliferation, migration and apoptosis in bladder cancer. Oncol Lett 16:5875-5881 (2018). PubMed: 30344738
  • Zhang J  et al. Iodine-125 interstitial brachytherapy reduces tumor growth via Warburg effect inhibition in non-small cell lung cancer A549 ×enografts. Oncol Lett 16:5969-5977 (2018). PubMed: 30344747
  • Zhang Y  et al. Downregulated miR-621 promotes cell proliferation via targeting CAPRIN1 in hepatocellular carcinoma. Am J Cancer Res 8:2116-2129 (2018). PubMed: 30416861
  • Chong IY  et al. Mapping genetic vulnerabilities reveals BTK as a novel therapeutic target in oesophageal cancer. Gut 67:1780-1792 (2018). PubMed: 28830912
  • Mitchell S  et al. Nongenetic origins of cell-to-cell variability in B lymphocyte proliferation. Proc Natl Acad Sci U S A 115:E2888-E2897 (2018). PubMed: 29514960
  • Weniger MA  et al. Human CD30+ B cells represent a unique subset related to Hodgkin lymphoma cells. J Clin Invest 128:2996-3007 (2018). PubMed: 29889102
  • Cai J  et al. A RhoA-YAP-c-Myc signaling axis promotes the development of polycystic kidney disease. Genes Dev 32:781-793 (2018). PubMed: 29891559
  • Li YJ  et al. Regulation of miR-34b/c-targeted gene expression program by SUMOylation. Nucleic Acids Res 46:7108-7123 (2018). PubMed: 29893976
  • Allan LA  et al. Atypical APC/C-dependent degradation of Mcl-1 provides an apoptotic timer during mitotic arrest. EMBO J 37:N/A (2018). PubMed: 29987118
  • Yuan Y  et al. Proliferative role of BDNF/TrkB signaling is associated with anoikis resistance in cervical cancer. Oncol Rep 40:621-634 (2018). PubMed: 29989647
  • Peng X  et al. HOXA5 is a tumor suppressor gene that is decreased in gastric cancer. Oncol Rep 40:1317-1329 (2018). PubMed: 30015922
  • Yakulov TA  et al. CXCL12 and MYC control energy metabolism to support adaptive responses after kidney injury. Nat Commun 9:3660 (2018). PubMed: 30202007
  • Wang S  et al. SH2B1 promotes NSCLC cell proliferation through PI3K/Akt/mTOR signaling cascade. Cancer Cell Int 18:132 (2018). PubMed: 30202243
  • Cao L  et al. AR-PDEF pathway promotes tumour proliferation and upregulates MYC-mediated gene transcription by promoting MAD1 degradation in ER-negative breast cancer. Mol Cancer 17:136 (2018). PubMed: 30217192
  • Calabrese DR  et al. Chemical and structural studies provide a mechanistic basis for recognition of the MYC G-quadruplex. Nat Commun 9:4229 (2018). PubMed: 30315240
  • Liu Y  et al. Nuclear lactate dehydrogenase A senses ROS to produce a-hydroxybutyrate for HPV-induced cervical tumor growth. Nat Commun 9:4429 (2018). PubMed: 30356100
  • Zhang X  et al. circRNA_104075 stimulates YAP-dependent tumorigenesis through the regulation of HNF4a and may serve as a diagnostic marker in hepatocellular carcinoma. Cell Death Dis 9:1091 (2018). PubMed: 30361504
  • Zhu X  et al. Synergistic effects of BET and MEK inhibitors promote regression of anaplastic thyroid tumors. Oncotarget 9:35408-35421 (2018). PubMed: 30459933
  • Shen Y  et al. S1P/S1PR3 axis promotes aerobic glycolysis by YAP/c-MYC/PGAM1 axis in osteosarcoma. EBioMedicine N/A:N/A (2018). PubMed: 30587459
  • Bao Y  et al. Carnosine Inhibits the Proliferation of Human Cervical Gland Carcinoma Cells Through Inhibiting Both Mitochondrial Bioenergetics and Glycolysis Pathways and Retarding Cell Cycle Progression. Integr Cancer Ther 17:80-91 (2018). PubMed: 28008780
  • Li B  et al. Targeting glutaminase 1 attenuates stemness properties in hepatocellular carcinoma by increasing reactive oxygen species and suppressing Wnt/beta-catenin pathway. EBioMedicine N/A:N/A (2018). PubMed: 30555042
  • Duan X  et al. FOXP3 inhibits MYC expression via regulating miR-198 and influences cell viability, proliferation and cell apoptosis in HepG2. Cancer Med 7:6182-6192 (2018). PubMed: 30378283
  • Zeng M  et al. Targeting MYC dependency in ovarian cancer through inhibition of CDK7 and CDK12/13. Elife 7:N/A (2018). PubMed: 30422115
  • Chen M  et al. Paris Saponin II inhibits colorectal carcinogenesis by regulating mitochondrial fission and NF-?B pathway. Pharmacol Res 139:273-285 (2018). PubMed: 30471409
  • Chan KH  et al. Impact of Target Warhead and Linkage Vector on Inducing Protein Degradation: Comparison of Bromodomain and Extra-Terminal (BET) Degraders Derived from Triazolodiazepine (JQ1) and Tetrahydroquinoline (I-BET726) BET Inhibitor Scaffolds. J Med Chem 61:504-513 (2018). PubMed: 28595007
  • Mishra P  et al. ADHFE1 is a breast cancer oncogene and induces metabolic reprogramming. J Clin Invest 128:323-340 (2018). PubMed: 29202474
  • Gallagher SJ  et al. HDAC inhibitors restore BRAF-inhibitor sensitivity by altering PI3K and survival signalling in a subset of melanoma. Int J Cancer 142:1926-1937 (2018). PubMed: 29210065
  • Mo H  et al. ATF4 regulated by MYC has an important function in anoikis resistance in human osteosarcoma cells. Mol Med Rep 17:3658-3666 (2018). PubMed: 29257326
  • Haikala HM  et al. Myc requires RhoA/SRF to reprogram glutamine metabolism. Small GTPases 9:274-282 (2018). PubMed: 27532209
  • Tuzlak S  et al. Differential effects of Vav-promoter-driven overexpression of BCLX and BFL1 on lymphocyte survival and B cell lymphomagenesis. FEBS J 285:1403-1418 (2018). PubMed: 29498802
  • Zhang Y  et al. CREPT facilitates colorectal cancer growth through inducing Wnt/ß-catenin pathway by enhancing p300-mediated ß-catenin acetylation. Oncogene 37:3485-3500 (2018). PubMed: 29563608
  • Wang S  et al. Effect of aromatase inhibitor letrozole on the proliferation of spermatogonia by regulating the MAPK pathway. Exp Ther Med 15:5269-5274 (2018). PubMed: 29805545
  • Xiang Z  et al. Cross-Database Analysis Reveals Sensitive Biomarkers for Combined Therapy for ERBB2+ Gastric Cancer. Front Pharmacol 9:861 (2018). PubMed: 30123134
  • Wang Y  et al. Long non-coding RNA DSCR8 acts as a molecular sponge for miR-485-5p to activate Wnt/ß-catenin signal pathway in hepatocellular carcinoma. Cell Death Dis 9:851 (2018). PubMed: 30154476
  • Geng W  et al. Resveratrol inhibits proliferation, migration and invasion of multiple myeloma cells via NEAT1-mediated Wnt/ß-catenin signaling pathway. Biomed Pharmacother 107:484-494 (2018). PubMed: 30107344
  • Ren Y  et al. PLK1 stabilizes a MYC-dependent kinase network in aggressive B cell lymphomas. J Clin Invest 128:5517-5530 (2018). PubMed: 30260324
  • Kubota T  et al. Age and CD20 Expression Are Significant Prognostic Factors in Human Herpes Virus-8-negative Effusion-based Lymphoma. Am J Surg Pathol 42:1607-1616 (2018). PubMed: 30273194
  • Fan P  et al. Far upstream element-binding protein 1 is up-regulated in pancreatic cancer and modulates immune response by increasing programmed death ligand 1. Biochem Biophys Res Commun 505:830-836 (2018). PubMed: 30301530
  • Lewis LM  et al. Replication Study: Transcriptional amplification in tumor cells with elevated c-Myc. Elife 7:N/A (2018). PubMed: 29313490
  • Ikenoue T  et al. Establishment and analysis of a novel mouse line carrying a conditional knockin allele of a cancer-specific FBXW7 mutation. Sci Rep 8:2021 (2018). WB ; Mouse . PubMed: 29386660
  • Zhu L  et al. TIPE2 suppresses progression and tumorigenesis of esophageal carcinoma via inhibition of the Wnt/ß-catenin pathway. J Transl Med 16:7 (2018). PubMed: 29343267
  • Akiyama T  et al. Efficient differentiation of human pluripotent stem cells into skeletal muscle cells by combining RNA-based MYOD1-expression and POU5F1-silencing. Sci Rep 8:1189 (2018). PubMed: 29352121
  • Pettersson A  et al. MYC Overexpression at the Protein and mRNA Level and Cancer Outcomes among Men Treated with Radical Prostatectomy for Prostate Cancer. Cancer Epidemiol Biomarkers Prev 27:201-207 (2018). PubMed: 29141848
  • Gonsalves WI  et al. Glutamine-derived 2-hydroxyglutarate is associated with disease progression in plasma cell malignancies. JCI Insight 3:N/A (2018). PubMed: 29321378
  • Natale CA  et al. Activation of G protein-coupled estrogen receptor signaling inhibits melanoma and improves response to immune checkpoint blockade. Elife 7:N/A (2018). PubMed: 29336307
  • Groulx JF  et al. MYC Regulates a6 Integrin Subunit Expression and Splicing Under Its Pro-Proliferative ITGA6A Form in Colorectal Cancer Cells. Cancers (Basel) 10:N/A (2018). PubMed: 29401653
  • Murai N  et al. Novel ubiquitin-independent nucleolar c-Myc degradation pathway mediated by antizyme 2. Sci Rep 8:3005 (2018). PubMed: 29445227
  • Niemas-Teshiba R  et al. MYC-family protein overexpression and prominent nucleolar formation represent prognostic indicators and potential therapeutic targets for aggressive high-MKI neuroblastomas: a report from the children's oncology group. Oncotarget 9:6416-6432 (2018). PubMed: 29464082
  • Huang Y  et al. S6K1 phosphorylation-dependent degradation of Mxi1 by ß-Trcp ubiquitin ligase promotes Myc activation and radioresistance in lung cancer. Theranostics 8:1286-1300 (2018). PubMed: 29507620
  • Zhao SJ  et al. SLIT2/ROBO1 axis contributes to the Warburg effect in osteosarcoma through activation of SRC/ERK/c-MYC/PFKFB2 pathway. Cell Death Dis 9:390 (2018). PubMed: 29523788
  • Li Z  et al. Novel biomarkerZCCHC13revealed by integrating DNA methylation and mRNA expression data in non-obstructive azoospermia. Cell Death Discov 4:36 (2018). PubMed: 29531833
  • Zhang L  et al. Eya3 partners with PP2A to induce c-Myc stabilization and tumor progression. Nat Commun 9:1047 (2018). PubMed: 29535359
  • Wang W  et al. SOX2OT variant 7 contributes to the synergistic interaction between EGCG and Doxorubicin to kill osteosarcoma via autophagy and stemness inhibition. J Exp Clin Cancer Res 37:37 (2018). WB ; Human . PubMed: 29475441
  • Colini Baldeschi A  et al. Atrial Natriuretic Peptide Acts as a Neuroprotective Agent in in Vitro Models of Parkinson's Disease via Up-regulation of the Wnt/ß-Catenin Pathway. Front Aging Neurosci 10:20 (2018). WB . PubMed: 29449807
  • Monteverde T  et al. Calcium signalling links MYC to NUAK1. Oncogene 37:982-992 (2018). PubMed: 29106388
  • Ma Y  et al. High expression of PRPS1 induces an anti-apoptotic effect in B-ALL cell lines and predicts an adverse prognosis in Chinese children with B-ALL. Oncol Lett 15:4314-4322 (2018). PubMed: 29541198
  • Jiang Y  et al. MAP30 promotes apoptosis of U251 and U87 cells by suppressing the LGR5 and Wnt/ß-catenin signaling pathway, and enhancing Smac expression. Oncol Lett 15:5833-5840 (2018). PubMed: 29556310
  • Arribas Arranz J  et al. Suitability of Yin Yang 1 transcript and protein levels for biomarker studies in B cell non-Hodgkin lymphoma. Biomark Res 6:11 (2018). PubMed: 29564133
  • Malchenko S  et al. Characterization of brain tumor initiating cells isolated from an animal model of CNS primitive neuroectodermal tumors. Oncotarget 9:13733-13747 (2018). PubMed: 29568390
  • Allen J  et al. Co-expression of MYC and BCL2 predicts poorer outcomes for relapsed/refractory diffuse large B-cell lymphoma with R-ICE and intent to transplant. Ther Adv Hematol 9:81-87 (2018). IHC-P ; Human . PubMed: 29623179
  • Qian W  et al. Secretome analysis of rat osteoblasts during icariin treatment induced osteogenesis. Mol Med Rep 17:6515-6525 (2018). PubMed: 29532868
  • Hirth CG  et al. PanCD44 Immunohistochemical Evaluation in Prostatectomies from Patients with Adenocarcinoma. Biomed Res Int 2018:2061268 (2018). PubMed: 29682524
  • Sun M  et al. Targeted delivery of immuno-RNase may improve cancer therapy. Cancer Cell Int 18:58 (2018). PubMed: 29686536
  • Wang F & Sun Y Overexpression of Myosin Phosphatase Target Subunit 1 (MYPT1) Inhibits Tumor Progression and Metastasis of Gastric Cancer. Med Sci Monit 24:2508-2517 (2018). PubMed: 29687789
  • Ji F  et al. Low expression of c-Myc protein predicts poor outcomes in patients with hepatocellular carcinoma after resection. BMC Cancer 18:460 (2018). PubMed: 29690860
  • Brandt LP  et al. Mouse genetic background influences whether HrasG12V expression plus Cdkn2a knockdown causes angiosarcoma or undifferentiated pleomorphic sarcoma. Oncotarget 9:19753-19766 (2018). PubMed: 29731980
  • Chen L  et al. Natural Compound Methyl Protodioscin Suppresses Proliferation and Inhibits Glycolysis in Pancreatic Cancer. Evid Based Complement Alternat Med 2018:7343090 (2018). PubMed: 29736179
  • Gao H  et al. LncRNA ZEB2-AS1 promotes pancreatic cancer cell growth and invasion through regulating the miR-204/HMGB1 axis. Int J Biol Macromol 116:545-551 (2018). PubMed: 29753015
  • Steger CM  et al. Gene therapy with antisense oligonucleotides silencing c-myc reduces neointima formation and vessel wall thickness in a mouse model of vein graft disease. Exp Mol Pathol 105:1-9 (2018). IHC-P ; Mouse . PubMed: 29775572
  • Duan Z  et al. Importin a5 negatively regulates importin ß1-mediated nuclear import of Newcastle disease virus matrix protein and viral replication and pathogenicity in chicken fibroblasts. Virulence 9:783-803 (2018). PubMed: 29532715
  • Chau KF  et al. Downregulation of ribosome biogenesis during early forebrain development. Elife 7:N/A (2018). PubMed: 29745900
  • Huang PS  et al. The Long Non-Coding RNA MIR503HG Enhances Proliferation of Human ALK-Negative Anaplastic Large-Cell Lymphoma. Int J Mol Sci 19:N/A (2018). WB . PubMed: 29758012
  • Zhang C  et al. The novel 19q13 KRAB zinc-finger tumour suppressor ZNF382 is frequently methylated in oesophageal squamous cell carcinoma and antagonises Wnt/ß-catenin signalling. Cell Death Dis 9:573 (2018). PubMed: 29760376
  • Lei T  et al. Cyclin K regulates prereplicative complex assembly to promote mammalian cell proliferation. Nat Commun 9:1876 (2018). PubMed: 29760377
  • Wang X  et al. Sarcodon imbricatus polysaccharides improve mouse hematopoietic function after cyclophosphamide-induced damage via G-CSF mediated JAK2/STAT3 pathway. Cell Death Dis 9:578 (2018). PubMed: 29784961
  • Wang Q  et al. NHERF1 inhibits beta-catenin-mediated proliferation of cervical cancer cells through suppression of alpha-actinin-4 expression. Cell Death Dis 9:668 (2018). PubMed: 29867145
  • Meder L  et al. LIN28B enhanced tumorigenesis in an autochthonous KRASG12V-driven lung carcinoma mouse model. Oncogene 37:2746-2756 (2018). PubMed: 29503447
  • Menguy S  et al. Double-hit or dual expression of MYC and BCL2 in primary cutaneous large B-cell lymphomas. Mod Pathol N/A:N/A (2018). PubMed: 29581544
  • Scully KM  et al. E47 Governs the MYC-CDKN1B/p27KIP1-RB Network to Growth Arrest PDA Cells Independent of CDKN2A/p16INK4A and Wild-Type p53. Cell Mol Gastroenterol Hepatol 6:181-198 (2018). PubMed: 30003124
  • Zhao N  et al. Pharmacological targeting of MYC-regulated IRE1/XBP1 pathway suppresses MYC-driven breast cancer. J Clin Invest 128:1283-1299 (2018). PubMed: 29480818
  • Nie X  et al. mTOR acts as a pivotal signaling hub for neural crest cells during craniofacial development. PLoS Genet 14:e1007491 (2018). PubMed: 29975682
  • Weltner J  et al. Human pluripotent reprogramming with CRISPR activators. Nat Commun 9:2643 (2018). PubMed: 29980666
  • Cummins CB  et al. Luteolin-Mediated Inhibition of Hepatic Stellate Cell Activation via Suppression of the STAT3 Pathway. Int J Mol Sci 19:N/A (2018). PubMed: 29795016
  • Teng CF  et al. Liver regeneration accelerates hepatitis B virus-related tumorigenesis of hepatocellular carcinoma. Mol Oncol 12:1175-1187 (2018). PubMed: 29729074
  • Xu X  et al. PBX3/MEK/ERK1/2/LIN28/let-7b positive feedback loop enhances mesenchymal phenotype to promote glioblastoma migration and invasion. J Exp Clin Cancer Res 37:158 (2018). PubMed: 30016974
  • Zou J  et al. MYC inhibition increases PD-L1 expression induced by IFN-? in hepatocellular carcinoma cells. Mol Immunol 101:203-209 (2018). PubMed: 30007230
  • Wang J  et al. Collaborating genomic, transcriptomic and microbiomic alterations lead to canine extreme intestinal polyposis. Oncotarget 9:29162-29179 (2018). PubMed: 30018743
  • Henry KE  et al. Noninvasive 89Zr-Transferrin PET Shows Improved Tumor Targeting Compared with 18F-FDG PET in MYC-Overexpressing Human Triple-Negative Breast Cancer. J Nucl Med 59:51-57 (2018). PubMed: 28848040
  • Xin J  et al. miR-204 functions as a tumor suppressor gene, at least partly by suppressing CYP27A1 in glioblastoma. Oncol Lett 16:1439-1448 (2018). PubMed: 30008822
  • Cai L  et al. Naringin inhibits ovarian tumor growth by promoting apoptosis: An in vivo study. Oncol Lett 16:59-64 (2018). PubMed: 29928387
  • Donnella HJ  et al. Kinome rewiring reveals AURKA limits PI3K-pathway inhibitor efficacy in breast cancer. Nat Chem Biol 14:768-777 (2018). PubMed: 29942081
  • Yang WH  et al. Heterogeneous nuclear ribonucleoprotein M promotes the progression of breast cancer by regulating the axin/ß-catenin signaling pathway. Biomed Pharmacother 105:848-855 (2018). PubMed: 30021377
  • Xie H  et al. IRE1a RNase-dependent lipid homeostasis promotes survival in Myc-transformed cancers. J Clin Invest 128:1300-1316 (2018). PubMed: 29381485
  • Wang X  et al. Downregulation of YAP inhibits proliferation, invasion and increases cisplatin sensitivity in human hepatocellular carcinoma cells. Oncol Lett 16:585-593 (2018). PubMed: 29928445
  • Baena-Del Valle JA  et al. MYC drives overexpression of telomerase RNA (hTR/TERC) in prostate cancer. J Pathol 244:11-24 (2018). IHC-P ; Human . PubMed: 28888037
  • Wang J  et al. Targeting c-Myc: JQ1 as a promising option for c-Myc-amplified esophageal squamous cell carcinoma. Cancer Lett 419:64-74 (2018). PubMed: 29366803
  • Wang S  et al. SH2B1 promotes epithelial-mesenchymal transition through the IRS1/ß-catenin signaling axis in lung adenocarcinoma. Mol Carcinog 57:640-652 (2018). WB ; Human . PubMed: 29380446
  • Shannon ML  et al. Mice Expressing Myc in Neural Precursors Develop Choroid Plexus and Ciliary Body Tumors. Am J Pathol 188:1334-1344 (2018). PubMed: 29545198
  • Wang D  et al. MiR-182 promotes prostate cancer progression through activating Wnt/ß-catenin signal pathway. Biomed Pharmacother 99:334-339 (2018). WB . PubMed: 29353209
  • Zhang B  et al. Bitterness in sugar: O-GlcNAcylation aggravates pre-B acute lymphocytic leukemia through glycolysis via the PI3K/Akt/c-Myc pathway. Am J Cancer Res 7:1337-1349 (2017). WB ; Human . PubMed: 28670495
  • Oh JM  et al. U1 snRNP telescripting regulates a size-function-stratified human genome. Nat Struct Mol Biol 24:993-999 (2017). WB ; Human . PubMed: 28967884
  • Ma SD  et al. Latent Membrane Protein 1 (LMP1) and LMP2A Collaborate To Promote Epstein-Barr Virus-Induced B Cell Lymphomas in a Cord Blood-Humanized Mouse Model but Are Not Essential. J Virol 91:N/A (2017). IHC . PubMed: 28077657
  • Flores A  et al. Lactate dehydrogenase activity drives hair follicle stem cell activation. Nat Cell Biol 19:1017-1026 (2017). PubMed: 28812580
  • Kalimutho M  et al. Enhanced dependency of KRAS-mutant colorectal cancer cells on RAD51-dependent homologous recombination repair identified from genetic interactions in Saccharomyces cerevisiae. Mol Oncol 11:470-490 (2017). PubMed: 28173629
  • Wang T  et al. Fibulin-4 is associated with prognosis of endometrial cancer patients and inhibits cancer cell invasion and metastasis via Wnt/ß-catenin signaling pathway. Oncotarget 8:18991-19012 (2017). PubMed: 28177909
  • Justus CR  et al. Contextual tumor suppressor function of T cell death-associated gene 8 (TDAG8) in hematological malignancies. J Transl Med 15:204 (2017). IHC . PubMed: 29017562
  • Effenberger M  et al. Glutaminase inhibition in multiple myeloma induces apoptosis via MYC degradation. Oncotarget 8:85858-85867 (2017). WB ; Human . PubMed: 29156762
  • Rinaldi L  et al. Mitochondrial AKAP1 supports mTOR pathway and tumor growth. Cell Death Dis 8:e2842 (2017). IHC ; Human . PubMed: 28569781
  • Rohban S  et al. The cohesin complex prevents Myc-induced replication stress. Cell Death Dis 8:e2956 (2017). WB . PubMed: 28749464
  • Tang L  et al. Expression of NUAK2 in gastric cancer tissue and its effects on the proliferation of gastric cancer cells. Exp Ther Med 13:676-680 (2017). PubMed: 28352350
  • Wang JH  et al. Overexpression of MYC and BCL2 Predicts Poor Prognosis in Patients with Extranodal NK/T-cell Lymphoma, Nasal Type. J Cancer 8:793-800 (2017). PubMed: 28382141
  • Singleton KR  et al. Melanoma Therapeutic Strategies that Select against Resistance by Exploiting MYC-Driven Evolutionary Convergence. Cell Rep 21:2796-2812 (2017). IHC-P ; Human . PubMed: 29212027
  • Fujii K  et al. MYB, MYBL1, MYBL2 and NFIB gene alterations and MYC overexpression in salivary gland adenoid cystic carcinoma. Histopathology 71:823-834 (2017). PubMed: 28594149
  • Marión RM  et al. Common Telomere Changes during In Vivo Reprogramming and Early Stages of Tumorigenesis. Stem Cell Reports 8:460-475 (2017). PubMed: 28162998
  • Fan J  et al. A novel role of CKIP-1 in promoting megakaryocytic differentiation. Oncotarget 8:30138-30150 (2017). PubMed: 28404913
  • Heo MH  et al. IRF4/MUM1 expression is associated with poor survival outcomes in patients with peripheral T-cell lymphoma. J Cancer 8:1018-1024 (2017). PubMed: 28529614
  • Ishii N  et al. Poor prognosis in cholangiocarcinoma patients with low FBXW7 expression is improved by chemotherapy. Oncol Lett 13:3653-3661 (2017). PubMed: 28521468
  • Xiao J  et al. Efficacy and tolerability of chemotherapy in Chinese patients with AIDS-related Burkitt lymphoma and diffuse large B-cell lymphoma: An observational study. Sci Rep 7:1905 (2017). PubMed: 28507339
  • Tian C  et al. ABCG1 as a potential oncogene in lung cancer. Exp Ther Med 13:3189-3194 (2017). PubMed: 28588672
  • Bolognesi MM  et al. Multiplex Staining by Sequential Immunostaining and Antibody Removal on Routine Tissue Sections. J Histochem Cytochem 65:431-444 (2017). PubMed: 28692376
  • Wang S  et al. Fibulin-3 promotes osteosarcoma invasion and metastasis by inducing epithelial to mesenchymal transition and activating the Wnt/ß-catenin signaling pathway. Sci Rep 7:6215 (2017). PubMed: 28740094
  • Peng Y  et al. Lovastatin Inhibits Cancer Stem Cells and Sensitizes to Chemo- and Photodynamic Therapy in Nasopharyngeal Carcinoma. J Cancer 8:1655-1664 (2017). PubMed: 28775785
  • Gupta N  et al. High Myc expression and transcription activity underlies intra-tumoral heterogeneity in triple-negative breast cancer. Oncotarget 8:28101-28115 (2017). IHC ; Human . PubMed: 28427212
  • Wang C  et al. Nicotine may promote tongue squamous cell carcinoma progression by activating the Wnt/ß-catenin and Wnt/PCP signaling pathways. Oncol Lett 13:3479-3486 (2017). Human . PubMed: 28521453
  • Liu X  et al. MiR-302a sensitizes leukemia cells to etoposide by targeting Rad52. Oncotarget 8:73884-73891 (2017). WB ; Human . PubMed: 29088754
  • Baudin M  et al. Analysis of the ZAR1 Immune Complex Reveals Determinants for Immunity and Molecular Interactions. Plant Physiol 174:2038-2053 (2017). WB, IP ; Nicotiana benthamiana . PubMed: 28652264
  • Jiang XN  et al. Anaplastic lymphoma kinase-positive large B-cell lymphoma: Clinico-pathological study of 17 cases with review of literature. PLoS One 12:e0178416 (2017). IHC-P ; Human . PubMed: 28665943
  • Matkar S  et al. Kinase inhibitors of HER2/AKT pathway induce ERK phosphorylation via a FOXO-dependent feedback loop. Am J Cancer Res 7:1476-1485 (2017). WB ; Human . PubMed: 28744398
  • Yahiaoui A  et al. PI3Kd inhibitor idelalisib in combination with BTK inhibitor ONO/GS-4059 in diffuse large B cell lymphoma with acquired resistance to PI3Kd and BTK inhibitors. PLoS One 12:e0171221 (2017). WB, IHC . PubMed: 28178345
  • Cui L  et al. Inhibition of coiled coil domain containing protein 69 enhances platinum-induced apoptosis in ovarian cancer cells. Oncotarget 8:101634-101648 (2017). PubMed: 29254192
  • Chen BJ  et al. Primary effusion lymphoma in Taiwan shows two distinctive clinicopathological subtypes with rare human immunodeficiency virus association. Histopathology N/A:N/A (2017). PubMed: 29206290
  • Janghorban M  et al. The tumor suppressor phosphatase PP2A-B56a regulates stemness and promotes the initiation of malignancies in a novel murine model. PLoS One 12:e0188910 (2017). PubMed: 29190822
  • Ninomiya T  et al. Iron depletion is a novel therapeutic strategy to target cancer stem cells. Oncotarget 8:98405-98416 (2017). PubMed: 29228699
  • Gnanasundram SV  et al. PI3Kd activates E2F1 synthesis in response to mRNA translation stress. Nat Commun 8:2103 (2017). PubMed: 29235459
  • Chen W  et al. MALAT1-miR-101-SOX9 feedback loop modulates the chemo-resistance of lung cancer cell to DDP via Wnt signaling pathway. Oncotarget 8:94317-94329 (2017). PubMed: 29212230
  • Rao SS  et al. Synergistic effect of eribulin and CDK inhibition for the treatment of triple negative breast cancer. Oncotarget 8:83925-83939 (2017). PubMed: 29137393
  • Schuler F  et al. Checkpoint kinase 1 is essential for normal B cell development and lymphomagenesis. Nat Commun 8:1697 (2017). PubMed: 29167438
  • Mogavero A  et al. Metformin transiently inhibits colorectal cancer cell proliferation as a result of either AMPK activation or increased ROS production. Sci Rep 7:15992 (2017). PubMed: 29167573
  • Farrell AS  et al. MYC regulates ductal-neuroendocrine lineage plasticity in pancreatic ductal adenocarcinoma associated with poor outcome and chemoresistance. Nat Commun 8:1728 (2017). PubMed: 29170413
  • Bellut J  et al. Differential prognostic value of MYC immunohistochemistry in subtypes of papillary renal cell carcinoma. Sci Rep 7:16424 (2017). PubMed: 29180625
  • Muzumdar MD  et al. Survival of pancreatic cancer cells lacking KRAS function. Nat Commun 8:1090 (2017). PubMed: 29061961
  • Gou Q  et al. Profiling and bioinformatic analysis of circular RNA expression regulated by c-Myc. Oncotarget 8:71587-71596 (2017). PubMed: 29069731
  • Mao XW  et al. CUL4B promotes bladder cancer metastasis and induces epithelial-to-mesenchymal transition by activating the Wnt/ß-catenin signaling pathway. Oncotarget 8:77241-77253 (2017). PubMed: 29100384
  • Ryan RJH  et al. A B Cell Regulome Links Notch to Downstream Oncogenic Pathways in Small B Cell Lymphomas. Cell Rep 21:784-797 (2017). PubMed: 29045844
  • Lou Y  et al. Linc-ROR induces epithelial-to-mesenchymal transition in ovarian cancer by increasing Wnt/ß-catenin signaling. Oncotarget 8:69983-69994 (2017). PubMed: 29050257
  • Lv C  et al. MiR-31 promotes mammary stem cell expansion and breast tumorigenesis by suppressing Wnt signaling antagonists. Nat Commun 8:1036 (2017). PubMed: 29051494
  • Tuo H  et al. MiR-324-3p promotes tumor growth through targeting DACT1 and activation of Wnt/ß-catenin pathway in hepatocellular carcinoma. Oncotarget 8:65687-65698 (2017). PubMed: 29029464
  • Gonçalves AF  et al. Evidence of renal angiomyolipoma neoplastic stem cells arising from renal epithelial cells. Nat Commun 8:1466 (2017). PubMed: 29133867
  • Chen M  et al. The nuclear transport receptor Importin-11 is a tumor suppressor that maintains PTEN protein. J Cell Biol 216:641-656 (2017). PubMed: 28193700
  • Riemer P  et al. Oncogenic ß-catenin and PIK3CA instruct network states and cancer phenotypes in intestinal organoids. J Cell Biol 216:1567-1577 (2017). PubMed: 28442534
  • Yuan Y  et al. miR-24-3p Is Overexpressed in Hodgkin Lymphoma and Protects Hodgkin and Reed-Sternberg Cells from Apoptosis. Am J Pathol 187:1343-1355 (2017). PubMed: 28432871
  • Salati S  et al. Deregulated expression of miR-29a-3p, miR-494-3p and miR-660-5p affects sensitivity to tyrosine kinase inhibitors in CML leukemic stem cells. Oncotarget 8:49451-49469 (2017). PubMed: 28533480
  • Bilger A  et al. Leflunomide/teriflunomide inhibit Epstein-Barr virus (EBV)- induced lymphoproliferative disease and lytic viral replication. Oncotarget 8:44266-44280 (2017). PubMed: 28574826
  • Xiang S  et al. Zinc-finger protein 545 is inactivated due to promoter methylation and functions as a tumor suppressor through the Wnt/ß-catenin, PI3K/AKT and MAPK/ERK signaling pathways in colorectal cancer. Int J Oncol 51:801-811 (2017). PubMed: 28677721
  • Li J  et al. miRNA-1284 inhibits cell growth and induces apoptosis of lung cancer cells. Mol Med Rep 16:3049-3054 (2017). PubMed: 28713980
  • Hu J  et al. Endoglin Is Essential for the Maintenance of Self-Renewal and Chemoresistance in Renal Cancer Stem Cells. Stem Cell Reports 9:464-477 (2017). PubMed: 28793246
  • Lu W  et al. Calf Spleen Extractive Injection protects mice against cyclophosphamide-induced hematopoietic injury through G-CSF-mediated JAK2/STAT3 signaling. Sci Rep 7:8402 (2017). PubMed: 28827748
  • Delás MJ  et al. lncRNA requirements for mouse acute myeloid leukemia and normal differentiation. Elife 6:N/A (2017). PubMed: 28875933
  • Liu B  et al. Transgenic overexpression of NanogP8 in the mouse prostate is insufficient to initiate tumorigenesis but weakly promotes tumor development in the Hi-Myc mouse model. Oncotarget 8:52746-52760 (2017). PubMed: 28881767
  • Trempolec N  et al. Induction of oxidative metabolism by the p38a/MK2 pathway. Sci Rep 7:11367 (2017). PubMed: 28900160
  • Wang F  et al. Morusin inhibits cell proliferation and tumor growth by down-regulating c-Myc in human gastric cancer. Oncotarget 8:57187-57200 (2017). PubMed: 28915664
  • Mu J  et al. Dickkopf-related protein 2 induces G0/G1 arrest and apoptosis through suppressing Wnt/ß-catenin signaling and is frequently methylated in breast cancer. Oncotarget 8:39443-39459 (2017). PubMed: 28467796
  • Nguyen L  et al. The Role of c-MYC in B-Cell Lymphomas: Diagnostic and Molecular Aspects. Genes (Basel) 8:N/A (2017). IHC-P . PubMed: 28379189
  • Quesada AE  et al. Increased MYC copy number is an independent prognostic factor in patients with diffuse large B-cell lymphoma. Mod Pathol 30:1688-1697 (2017). IHC-P ; Human . PubMed: 28776574
  • Weng S  et al. Restoration of MYC-repressed targets mediates the negative effects of GM-CSF on RUNX1-ETO leukemogenicity. Leukemia 31:159-169 (2017). WB . PubMed: 27389055
  • Lu T  et al. Adamts18 deficiency promotes colon carcinogenesis by enhancing ß-catenin and p38MAPK/ERK1/2 signaling in the mouse model of AOM/DSS-induced colitis-associated colorectal cancer. Oncotarget 8:18979-18990 (2017). WB, IHC ; Mouse . PubMed: 28145888
  • Yuan H  et al. HPV positive neuroendocrine cervical cancer cells are dependent on Myc but not E6/E7 viral oncogenes. Sci Rep 7:45617 (2017). IHC-P ; Human . PubMed: 28378747
  • Barfeld SJ  et al. c-Myc Antagonises the Transcriptional Activity of the Androgen Receptor in Prostate Cancer Affecting Key Gene Networks. EBioMedicine 18:83-93 (2017). WB, IHC ; Human . PubMed: 28412251
  • Hogg SJ  et al. BET-Bromodomain Inhibitors Engage the Host Immune System and Regulate Expression of the Immune Checkpoint Ligand PD-L1. Cell Rep 18:2162-2174 (2017). ChIP ; Human . PubMed: 28249162
  • Ma L  et al. Long non-coding RNA XIST promotes cell growth and invasion through regulating miR-497/MACC1 axis in gastric cancer. Oncotarget 8:4125-4135 (2017). WB ; Human . PubMed: 27911852
  • Lines KE  et al. Epigenetic pathway inhibitors represent potential drugs for treating pancreatic and bronchial neuroendocrine tumors. Oncogenesis 6:e332 (2017). WB ; Mouse . PubMed: 28504695
  • Xin B  et al. Critical role of Myc activation in mouse hepatocarcinogenesis induced by the activation of AKT and RAS pathways. Oncogene N/A:N/A (2017). IHC-P ; Mouse . PubMed: 28481866
  • Malchenko S  et al. Stabilization of HIF-1a and HIF-2a, up-regulation of MYCC and accumulation of stabilized p53 constitute hallmarks of CNS-PNET animal model. PLoS One 12:e0173106 (2017). IHC-P ; Human . PubMed: 28249000
  • Zhang C  et al. TRIM8 regulates stemness in glioblastoma through PIAS3-STAT3. Mol Oncol 11:280-294 (2017). PubMed: 28100038
  • Anderton B  et al. MYC-driven inhibition of the glutamate-cysteine ligase promotes glutathione depletion in liver cancer. EMBO Rep 18:569-585 (2017). PubMed: 28219903
  • Gadd MS  et al. Structural basis of PROTAC cooperative recognition for selective protein degradation. Nat Chem Biol 13:514-521 (2017). PubMed: 28288108
  • Altman BJ  et al. Correspondence: Oncogenic MYC persistently upregulates the molecular clock component REV-ERBa. Nat Commun 8:14862 (2017). PubMed: 28332504
  • Sowalsky AG  et al. Gleason Score 7 Prostate Cancers Emerge through Branched Evolution of Clonal Gleason Pattern 3 and 4. Clin Cancer Res 23:3823-3833 (2017). PubMed: 28119368
  • Xie Y & Wang B Downregulation of TNFAIP2 suppresses proliferation and metastasis in esophageal squamous cell carcinoma through activation of the Wnt/ß-catenin signaling pathway. Oncol Rep 37:2920-2928 (2017). PubMed: 28393234
  • Yu P  et al. FGF-dependent metabolic control of vascular development. Nature 545:224-228 (2017). PubMed: 28467822
  • Asghar US  et al. Single-Cell Dynamics Determines Response to CDK4/6 Inhibition in Triple-Negative Breast Cancer. Clin Cancer Res 23:5561-5572 (2017). PubMed: 28606920
  • Izumi D  et al. Colorectal Cancer Stem Cells Acquire Chemoresistance Through the Upregulation of F-Box/WD Repeat-Containing Protein 7 and the Consequent Degradation of c-Myc. Stem Cells 35:2027-2036 (2017). PubMed: 28699179
  • Liao P  et al. Mutant p53 Gains Its Function via c-Myc Activation upon CDK4 Phosphorylation at Serine 249 and Consequent PIN1 Binding. Mol Cell 68:1134-1146.e6 (2017). PubMed: 29225033
  • Porter JR  et al. Global Inhibition with Specific Activation: How p53 and MYC Redistribute the Transcriptome in the DNA Double-Strand Break Response. Mol Cell 67:1013-1025.e9 (2017). PubMed: 28867293
  • Wang X  et al. BAMBI overexpression together with ß-sitosterol ameliorates NSCLC via inhibiting autophagy and inactivating TGF-ß/Smad2/3 pathway. Oncol Rep 37:3046-3054 (2017). PubMed: 28440452
  • Thomas AL  et al. Inhibition of CDK-mediated Smad3 phosphorylation reduces the Pin1-Smad3 interaction and aggressiveness of triple negative breast cancer cells. Cell Cycle 16:1453-1464 (2017). PubMed: 28678584
  • Dang H  et al. Oncogenic Activation of the RNA Binding Protein NELFE and MYC Signaling in Hepatocellular Carcinoma. Cancer Cell 32:101-114.e8 (2017). PubMed: 28697339
  • Jin X  et al. HO-1 alleviates cholesterol-induced oxidative stress through activation of Nrf2/ERK and inhibition of PI3K/AKT pathways in endothelial cells. Mol Med Rep 16:3519-3527 (2017). PubMed: 28713890
  • Xu Y  et al. LCMR1 interacts with DEK to suppress apoptosis in lung cancer cells. Mol Med Rep 16:4159-4164 (2017). PubMed: 28765911
  • Zhang J  et al. c-Myc promotes tumor proliferation and anti-apoptosis by repressing p21 in rhabdomyosarcomas. Mol Med Rep 16:4089-4094 (2017). PubMed: 28765944
  • Ahmed NS  et al. Epidermal E-Cadherin Dependent ß-Catenin Pathway Is Phytochemical Inducible and Accelerates Anagen Hair Cycling. Mol Ther 25:2502-2512 (2017). PubMed: 28803863
  • Thompson MA  et al. miR-31 and miR-17-5p levels change during transformation of follicular lymphoma. Hum Pathol 50:118-26 (2016). PubMed: 26997445
  • Ellis L  et al. Generation of a C57BL/6 MYC-Driven Mouse Model and Cell Line of Prostate Cancer. Prostate 76:1192-202 (2016). PubMed: 27225803
  • Zhu ZJ  et al. MicroRNA-181a promotes proliferation and inhibits apoptosis by suppressing CFIm25 in osteosarcoma. Mol Med Rep 14:4271-4278 (2016). PubMed: 27633853
  • Zhu J  et al. Advanced glycosylation end product promotes forkhead box O1 and inhibits Wnt pathway to suppress capacities of epidermal stem cells. Am J Transl Res 8:5569-5579 (2016). PubMed: 28078027
  • Brasó-Maristany F  et al. PIM1 kinase regulates cell death, tumor growth and chemotherapy response in triple-negative breast cancer. Nat Med 22:1303-1313 (2016). PubMed: 27775704
  • Hall Z  et al. Myc Expression Drives Aberrant Lipid Metabolism in Lung Cancer. Cancer Res 76:4608-18 (2016). IHC-P ; Human . PubMed: 27335109
  • Ma L  et al. Fat4 suppression induces Yap translocation accounting for the promoted proliferation and migration of gastric cancer cells. Cancer Biol Ther 17:36-47 (2016). WB ; Human . PubMed: 26575609
  • Wu Y  et al. Low expression of secreted frizzled-related protein 2 and nuclear accumulation of ß-catenin in aggressive nonfunctioning pituitary adenoma. Oncol Lett 12:199-206 (2016). WB ; Human . PubMed: 27347125
  • Li T  et al. Premalignant alteration assessment in liver-like tissue derived from embryonic stem cells by aristolochic acid I exposure. Oncotarget 7:78872-78882 (2016). ICC/IF ; Mouse . PubMed: 27713163
  • Nowacka JD  et al. MEK1 is required for the development of NRAS-driven leukemia. Oncotarget 7:80113-80130 (2016). WB ; Human . PubMed: 27741509
  • Griffin NI  et al. ADA3 regulates normal and tumor mammary epithelial cell proliferation through c-MYC. Breast Cancer Res 18:113 (2016). WB ; Human . PubMed: 27852327
  • Yu Y  et al. Preterm infant gut microbiota affects intestinal epithelial development in a humanized microbiome gnotobiotic mouse model. Am J Physiol Gastrointest Liver Physiol 311:G521-32 (2016). IHC ; Human . PubMed: 27492329
  • Nakazawa MS  et al. Epigenetic re-expression of HIF-2a suppresses soft tissue sarcoma growth. Nat Commun 7:10539 (2016). WB . PubMed: 26837714
  • Hanaford AR  et al. DiSCoVERing Innovative Therapies for Rare Tumors: Combining Genetically Accurate Disease Models with In Silico Analysis to Identify Novel Therapeutic Targets. Clin Cancer Res 22:3903-14 (2016). PubMed: 27012813
  • Oh EJ  et al. Long Non-coding RNA HOTAIR Expression in Diffuse Large B-Cell Lymphoma: In Relation to Polycomb Repressive Complex Pathway Proteins and H3K27 Trimethylation. J Pathol Transl Med 50:369-76 (2016). PubMed: 27550047
  • Sun X  et al. MAVS maintains mitochondrial homeostasis via autophagy. Cell Discov 2:16024 (2016). PubMed: 27551434
  • Maeshima AM  et al. Clinicopathological features of histological transformation from extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue to diffuse large B-cell lymphoma: an analysis of 467 patients. Br J Haematol 174:923-31 (2016). PubMed: 27460179
  • Huang YW  et al. Black raspberries demethylate Sfrp4, a WNT pathway antagonist, in rat esophageal squamous cell papilloma. Mol Carcinog 55:1867-1875 (2016). PubMed: 27696538
  • Choe JY  et al. PELI1 expression is correlated with MYC and BCL6 expression and associated with poor prognosis in diffuse large B-cell lymphoma. Mod Pathol 29:1313-1323 (2016). PubMed: 27469333
  • Gao K  et al. Deregulated WWOX is involved in a negative feedback loop with microRNA-214-3p in osteosarcoma. Int J Mol Med N/A:N/A (2016). WB . PubMed: 27840941
  • Courville EL  et al. EBV-negative monomorphic B-cell post-transplant lymphoproliferative disorders are pathologically distinct from EBV-positive cases and frequently contain TP53 mutations. Mod Pathol 29:1200-11 (2016). PubMed: 27443517
  • Gupta NK  et al. Long-term survival in AIDS-related primary central nervous system lymphoma. Neuro Oncol N/A:N/A (2016). PubMed: 27576871
  • Manerba M  et al. Lactate dehydrogenase inhibitors can reverse inflammation induced changes in colon cancer cells. Eur J Pharm Sci 96:37-44 (2016). PubMed: 27622920
  • Rui L  et al. Epigenetic gene regulation by Janus kinase 1 in diffuse large B-cell lymphoma. Proc Natl Acad Sci U S A 113:E7260-E7267 (2016). PubMed: 27799566
  • Dela Cruz FS  et al. A case study of an integrative genomic and experimental therapeutic approach for rare tumors: identification of vulnerabilities in a pediatric poorly differentiated carcinoma. Genome Med 8:116 (2016). WB . PubMed: 27799065
  • Wu C  et al. A positive feedback loop involving the Wnt/ß-catenin/MYC/Sox2 axis defines a highly tumorigenic cell subpopulation in ALK-positive anaplastic large cell lymphoma. J Hematol Oncol 9:120 (2016). IHC, ICC/IF . PubMed: 27821172
  • Zhao X  et al. Inhibition of mTORC1 signaling sensitizes hepatocellular carcinoma cells to glycolytic stress. Am J Cancer Res 6:2289-2298 (2016). WB ; Human . PubMed: 27822418
  • Lorenzin F  et al. Different promoter affinities account for specificity in MYC-dependent gene regulation. Elife 5:N/A (2016). PubMed: 27460974
  • Shi X  et al. Loss of TRIM33 causes resistance to BET bromodomain inhibitors through MYC- and TGF-ß-dependent mechanisms. Proc Natl Acad Sci U S A 113:E4558-66 (2016). PubMed: 27432991
  • Han A  et al. p63a modulates c-Myc activity via direct interaction and regulation of MM1 protein stability. Oncotarget 7:44277-44287 (2016). WB ; Human . PubMed: 27341130
  • Grampp S  et al. Genetic variation at the 8q24.21 renal cancer susceptibility locus affects HIF binding to a MYC enhancer. Nat Commun 7:13183 (2016). WB, IHC-P ; Human . PubMed: 27774982
  • Jin YJ  et al. Epidermal CYLD inactivation sensitizes mice to the development of sebaceous and basaloid skin tumors. JCI Insight 1:N/A (2016). IF, IHC . PubMed: 27478875
  • Lee KS  et al. Favorable prognosis in colorectal cancer patients with co-expression of c-MYC and ß-catenin. BMC Cancer 16:730 (2016). IHC-P ; Human . PubMed: 27619912
  • Qu F  et al. MicroRNA-26a induces osteosarcoma cell growth and metastasis via the Wnt/ß-catenin pathway. Oncol Lett 11:1592-1596 (2016). WB ; Human . PubMed: 26893786
  • Park JW  et al. Prostate epithelial cell of origin determines cancer differentiation state in an organoid transformation assay. Proc Natl Acad Sci U S A 113:4482-7 (2016). PubMed: 27044116
  • Rennoll SA  et al. The MYC 3' Wnt-Responsive Element Drives Oncogenic MYC Expression in Human Colorectal Cancer Cells. Cancers (Basel) 8:N/A (2016). WB ; Human . PubMed: 27223305
  • Chung SI  et al. Development of a transgenic mouse model of hepatocellular carcinoma with a liver fibrosis background. BMC Gastroenterol 16:13 (2016). WB, IHC-P . PubMed: 26821924
  • Boudjadi S  et al. Integrin a1ß1 expression is controlled by c-MYC in colorectal cancer cells. Oncogene 35:1671-8 (2016). WB, ChIP . PubMed: 26096932
  • Alexandrova S  et al. Selection and dynamics of embryonic stem cell integration into early mouse embryos. Development 143:24-34 (2016). PubMed: 26586221
  • Monaghan MG  et al. Endocardial-to-mesenchymal transformation and mesenchymal cell colonization at the onset of human cardiac valve development. Development 143:473-82 (2016). PubMed: 26674310
  • Kluk MJ  et al. MYC Immunohistochemistry to Identify MYC-Driven B-Cell Lymphomas in Clinical Practice. Am J Clin Pathol 145:166-79 (2016). PubMed: 26834124
  • Franco M  et al. A Novel Secreted Protein, MYR1, Is Central to Toxoplasma's Manipulation of Host Cells. MBio 7:e02231-15 (2016). WB . PubMed: 26838724
  • Agarwal R  et al. Role of immunohistochemistry in the era of genetic testing in MYC-positive aggressive B-cell lymphomas: a study of 209 cases. J Clin Pathol 69:266-70 (2016). PubMed: 26307073
  • Tian-Zhong M  et al. Critical role of Emx2 in the pluripotency - differentiation transition in male gonocytes via regulation of FGF9/NODAL pathway. Reproduction 151:673-81 (2016). PubMed: 27002001
  • Feng D  et al. Piwil2 is reactivated by HPV oncoproteins and initiates cell reprogramming via epigenetic regulation during cervical cancer tumorigenesis. Oncotarget 7:64575-64588 (2016). WB ; Human . PubMed: 27602489
  • Kress TR  et al. Identification of MYC-Dependent Transcriptional Programs in Oncogene-Addicted Liver Tumors. Cancer Res 76:3463-72 (2016). PubMed: 27197165
  • Kang J  et al. Amino acid-dependent signaling via S6K1 and MYC is essential for regulation of rDNA transcription. Oncotarget 7:48887-48904 (2016). PubMed: 27385002
  • Li X  et al. SREBP-2 promotes stem cell-like properties and metastasis by transcriptional activation of c-Myc in prostate cancer. Oncotarget 7:12869-84 (2016). IHC . PubMed: 26883200
  • Itkonen HM  et al. Inhibition of O-GlcNAc transferase activity reprograms prostate cancer cell metabolism. Oncotarget 7:12464-76 (2016). WB . PubMed: 26824323
  • Lynch JT  et al. Identification of differential PI3K pathway target dependencies in T-cell acute lymphoblastic leukemia through a large cancer cell panel screen. Oncotarget 7:22128-39 (2016). PubMed: 26989080
  • Hellner K  et al. Premalignant SOX2 overexpression in the fallopian tubes of ovarian cancer patients: Discovery and validation studies. EBioMedicine 10:137-49 (2016). PubMed: 27492892
  • Yang CX  et al. MicroRNA-320 regulates the radiosensitivity of cervical cancer cells C33AR by targeting ß-catenin. Oncol Lett 12:4983-4990 (2016). WB . PubMed: 28105205
  • Camarda R  et al. Inhibition of fatty acid oxidation as a therapy for MYC-overexpressing triple-negative breast cancer. Nat Med 22:427-32 (2016). WB . PubMed: 26950360
  • Liu T  et al. Capsaicin mediates caspases activation and induces apoptosis through P38 and JNK MAPK pathways in human renal carcinoma. BMC Cancer 16:790 (2016). PubMed: 27729033
  • Raina K  et al. PROTAC-induced BET protein degradation as a therapy for castration-resistant prostate cancer. Proc Natl Acad Sci U S A 113:7124-9 (2016). PubMed: 27274052
  • Swetzig WM  et al. Estrogen receptor alpha (ERa/ESR1) mediates the p53-independent overexpression of MDM4/MDMX and MDM2 in human breast cancer. Oncotarget 7:16049-69 (2016). WB . PubMed: 26909605
  • Shen H  et al. Lin28A activates androgen receptor via regulation of c-myc and promotes malignancy of ER-/Her2+ breast cancer. Oncotarget 7:60407-60418 (2016). WB . PubMed: 27494865
  • Feng J  et al. Aortic dissection is associated with reduced polycystin-1 expression, an abnormality that leads to increased ERK phosphorylation in vascular smooth muscle cells. Eur J Histochem 60:2711 (2016). PubMed: 28076932
  • Lee JY  et al. Novel Function of Sprouty4 as a Regulator of Stemness and Differentiation of Embryonic Stem Cells. Dev Reprod 20:171-7 (2016). WB . PubMed: 27660833
  • Tagde A  et al. MUC1-C drives MYC in multiple myeloma. Blood 127:2587-97 (2016). PubMed: 26907633
  • Zhao L  et al. Paired box 5 is a frequently methylated lung cancer tumour suppressor gene interfering ß-catenin signalling and GADD45G expression. J Cell Mol Med 20:842-54 (2016). WB ; Human . PubMed: 26843424
  • Ferreiro JF  et al. EBV-Positive and EBV-Negative Posttransplant Diffuse Large B Cell Lymphomas Have Distinct Genomic and Transcriptomic Features. Am J Transplant 16:414-25 (2016). IHC-P . PubMed: 26780579
  • Choe JY  et al. MYC overexpression correlates with MYC amplification or translocation, and is associated with poor prognosis in mantle cell lymphoma. Histopathology 68:442-9 (2016). PubMed: 26100211
  • Jin K  et al. Hepatic Premalignant Alterations Triggered by Human Nephrotoxin Aristolochic Acid I in Canines. Cancer Prev Res (Phila) 9:324-34 (2016). PubMed: 26851235
  • Harris KL  et al. Western diet enhances benzo(a)pyrene-induced colon tumorigenesis in a polyposis in rat coli (PIRC) rat model of colon cancer. Oncotarget 7:28947-60 (2016). PubMed: 26959117
  • Chen JL  et al. Suppression of SIK1 by miR-141 in human ovarian cancer cell lines and tissues. Int J Mol Med 37:1601-10 (2016). PubMed: 27081781
  • Song Y  et al. Novel 1, 3-N, O-Spiroheterocyclic compounds inhibit heparanase activity and enhance nedaplatin-induced cytotoxicity in cervical cancer cells. Oncotarget 7:36154-36167 (2016). PubMed: 27166252
  • He T  et al. Methylglyoxal suppresses human colon cancer cell lines and tumor growth in a mouse model by impairing glycolytic metabolism of cancer cells associated with down-regulation of c-Myc expression. Cancer Biol Ther 17:955-65 (2016). PubMed: 27455418
  • Li P  et al. Serum anti-MDM2 and anti-c-Myc autoantibodies as biomarkers in the early detection of lung cancer. Oncoimmunology 5:e1138200 (2016). PubMed: 27467958
  • Bond CE  et al. RNF43 and ZNRF3 are commonly altered in serrated pathway colorectal tumorigenesis. Oncotarget 7:70589-70600 (2016). PubMed: 27661107
  • Zhang Y  et al. GDF11 improves tubular regeneration after acute kidney injury in elderly mice. Sci Rep 6:34624 (2016). PubMed: 27703192
  • Zhang Q  et al. Fbxw7 Deletion Accelerates KrasG12D-Driven Pancreatic Tumorigenesis via Yap Accumulation. Neoplasia 18:666-673 (2016). PubMed: 27764699
  • Ocampo A  et al. In Vivo Amelioration of Age-Associated Hallmarks by Partial Reprogramming. Cell 167:1719-1733.e12 (2016). PubMed: 27984723
  • Lee SB  et al. Parkin Regulates Mitosis and Genomic Stability through Cdc20/Cdh1. Mol Cell 60:21-34 (2015). IP . PubMed: 26387737
  • Copie-Bergman C  et al. MYC-IG rearrangements are negative predictors of survival in DLBCL patients treated with immunochemotherapy: a GELA/LYSA study. Blood 126:2466-74 (2015). IHC-P ; Human . PubMed: 26373676
  • Tapia G  et al. MYC protein expression is associated with poor prognosis in primary diffuse large B-cell lymphoma of the central nervous system. APMIS 123:596-603 (2015). PubMed: 26010683
  • Wang LL  et al. Augmented expression of MYC and/or MYCN protein defines highly aggressive MYC-driven neuroblastoma: a Children's Oncology Group study. Br J Cancer 113:57-63 (2015). IHC-P ; Human . PubMed: 26035700
  • González-Prieto R  et al. c-Myc is targeted to the proteasome for degradation in a SUMOylation-dependent manner, regulated by PIAS1, SENP7 and RNF4. Cell Cycle 14:1859-72 (2015). PubMed: 25895136
  • Korangath P  et al. Targeting Glutamine Metabolism in Breast Cancer with Aminooxyacetate. Clin Cancer Res 21:3263-73 (2015). WB ; Human . PubMed: 25813021
  • Bjorklund CC  et al. Rate of CRL4(CRBN) substrate Ikaros and Aiolos degradation underlies differential activity of lenalidomide and pomalidomide in multiple myeloma cells by regulation of c-Myc and IRF4. Blood Cancer J 5:e354 (2015). IHC ; Human . PubMed: 26430725
  • Chang BS  et al. Collagen complexes increase the efficiency of iPS cells generated using fibroblasts from adult mice. J Reprod Dev 61:145-53 (2015). IF ; Mouse . PubMed: 25740096
  • Meng QB  et al. Overexpression of eukaryotic translation initiation factor 5A2 (EIF5A2) correlates with cell aggressiveness and poor survival in gastric cancer. PLoS One 10:e0119229 (2015). PubMed: 25793713
  • Mamada H  et al. Cell competition in mouse NIH3T3 embryonic fibroblasts is controlled by the activity of Tead family proteins and Myc. J Cell Sci 128:790-803 (2015). WB, ICC/IF . PubMed: 25588835
  • Linley A  et al. Lectin binding to surface Ig variable regions provides a universal persistent activating signal for follicular lymphoma cells. Blood 126:1902-10 (2015). PubMed: 26194765
  • Ma L  et al. Trap Effect of Three-Dimensional Fibers Network for High Efficient Cancer-Cell Capture. Adv Healthc Mater 4:838-43 (2015). PubMed: 25645204
  • He TL  et al. The c-Myc-LDHA axis positively regulates aerobic glycolysis and promotes tumor progression in pancreatic cancer. Med Oncol 32:187 (2015). IHC ; Human . PubMed: 26021472
  • Derenzini E  et al. Constitutive activation of the DNA damage response pathway as a novel therapeutic target in diffuse large B-cell lymphoma. Oncotarget 6:6553-69 (2015). IF . PubMed: 25544753
  • Simons BW  et al. A human prostatic bacterial isolate alters the prostatic microenvironment and accelerates prostate cancer progression. J Pathol 235:478-89 (2015). IHC ; Mouse . PubMed: 25348195
  • Li S  et al. Regulation of c-Myc protein stability by proteasome activator REG?. Cell Death Differ 22:1000-11 (2015). PubMed: 25412630
  • Lee JG & Wu R Erlotinib-cisplatin combination inhibits growth and angiogenesis through c-MYC and HIF-1a in EGFR-mutated lung cancer in vitro and in vivo. Neoplasia 17:190-200 (2015). WB ; Mouse, Human . PubMed: 25748238
  • Carey CD  et al. Molecular classification of MYC-driven B-cell lymphomas by targeted gene expression profiling of fixed biopsy specimens. J Mol Diagn 17:19-30 (2015). IHC ; Human . PubMed: 25468432
  • Xiang Y  et al. Targeted inhibition of tumor-specific glutaminase diminishes cell-autonomous tumorigenesis. J Clin Invest 125:2293-306 (2015). IHC . PubMed: 25915584
  • Zou Y  et al. Resveratrol inhibits canonical Wnt signaling in human MG-63 osteosarcoma cells. Mol Med Rep 12:7221-6 (2015). WB, ICC/IF ; Human . PubMed: 26398440
  • Lawson DA  et al. Single-cell analysis reveals a stem-cell program in human metastatic breast cancer cells. Nature 526:131-5 (2015). IHC-P ; Human . PubMed: 26416748
  • Morgado-Palacin L  et al. Partial Loss of Rpl11 in Adult Mice Recapitulates Diamond-Blackfan Anemia and Promotes Lymphomagenesis. Cell Rep 13:712-22 (2015). IHC-P ; Mouse . PubMed: 26489471
  • Siegfried JM  et al. Expression of PAM50 Genes in Lung Cancer: Evidence that Interactions between Hormone Receptors and HER2/HER3 Contribute to Poor Outcome. Neoplasia 17:817-25 (2015). IHC-P ; Human . PubMed: 26678909
  • Sun XX  et al. The nucleolar ubiquitin-specific protease USP36 deubiquitinates and stabilizes c-Myc. Proc Natl Acad Sci U S A 112:3734-9 (2015). PubMed: 25775507
  • Massari F  et al. Prognostic Value of Beta-Tubulin-3 and c-Myc in Muscle Invasive Urothelial Carcinoma of the Bladder. PLoS One 10:e0127908 (2015). IHC-P ; Human . PubMed: 26046361
  • Mahmoud AZ  et al. Scoring of MYC protein expression in diffuse large B-cell lymphomas: concordance rate among hematopathologists. Mod Pathol 28:545-51 (2015). IHC-P ; Human . PubMed: 25431238
  • Barfeld SJ  et al. Myc-dependent purine biosynthesis affects nucleolar stress and therapy response in prostate cancer. Oncotarget 6:12587-602 (2015). WB ; Human . PubMed: 25869206
  • Shokhirev MN  et al. A multi-scale approach reveals that NF-?B cRel enforces a B-cell decision to divide. Mol Syst Biol 11:783 (2015). ICC/IF ; Mouse . PubMed: 25680807
  • Tran D  et al. Functional genomics analysis reveals a MYC signature associated with a poor clinical prognosis in liposarcomas. Am J Pathol 185:717-28 (2015). IHC ; Human . PubMed: 25622542
  • Huang S  et al. Attenuation of microRNA-16 derepresses the cyclins D1, D2 and E1 to provoke cardiomyocyte hypertrophy. J Cell Mol Med 19:608-19 (2015). WB . PubMed: 25583328
  • Kozono D  et al. Dynamic epigenetic regulation of glioblastoma tumorigenicity through LSD1 modulation of MYC expression. Proc Natl Acad Sci U S A 112:E4055-64 (2015). IHC-P ; Mouse . PubMed: 26159421
  • Renaud SJ  et al. OVO-like 1 regulates progenitor cell fate in human trophoblast development. Proc Natl Acad Sci U S A 112:E6175-84 (2015). IHC-P, ICC/IF . PubMed: 26504231
  • Lu TX  et al. Epstein-Barr virus positive diffuse large B-cell lymphoma predict poor outcome, regardless of the age. Sci Rep 5:12168 (2015). IHC ; Human . PubMed: 26202875
  • Nowak DG  et al. MYC Drives Pten/Trp53-Deficient Proliferation and Metastasis due to IL6 Secretion and AKT Suppression via PHLPP2. Cancer Discov 5:636-51 (2015). PubMed: 25829425
  • Cattoglio C  et al. Functional and mechanistic studies of XPC DNA-repair complex as transcriptional coactivator in embryonic stem cells. Proc Natl Acad Sci U S A 112:E2317-26 (2015). PubMed: 25901318
  • Xie CM  et al. Erbin is a novel substrate of the Sag-ßTrCP E3 ligase that regulates KrasG12D-induced skin tumorigenesis. J Cell Biol 209:721-37 (2015). PubMed: 26056141
  • Shi J  et al. Deubiquitinase USP47/UBP64E Regulates ß-Catenin Ubiquitination and Degradation and Plays a Positive Role in Wnt Signaling. Mol Cell Biol 35:3301-11 (2015). PubMed: 26169834
  • Bhusari S  et al. Genomic Profiling Reveals Unique Molecular Alterations in Hepatoblastomas and Adjacent Hepatocellular Carcinomas in B6C3F1 Mice. Toxicol Pathol 43:1114-26 (2015). PubMed: 26289556
  • Amaya CN & Bryan BA Enrichment of the embryonic stem cell reprogramming factors Oct4, Nanog, Myc, and Sox2 in benign and malignant vascular tumors. BMC Clin Pathol 15:18 (2015). PubMed: 26412983
  • Lee KS  et al. c-MYC Copy-Number Gain Is an Independent Prognostic Factor in Patients with Colorectal Cancer. PLoS One 10:e0139727 (2015). PubMed: 26426996
  • Chen J  et al. Gliotoxin Inhibits Proliferation and Induces Apoptosis in Colorectal Cancer Cells. Mar Drugs 13:6259-73 (2015). PubMed: 26445050
  • Venant H  et al. The Sphingosine Kinase 2 Inhibitor ABC294640 Reduces the Growth of Prostate Cancer Cells and Results in Accumulation of Dihydroceramides In Vitro and In Vivo. Mol Cancer Ther 14:2744-52 (2015). PubMed: 26494858
  • Zhu YX  et al. RNA interference screening identifies lenalidomide sensitizers in multiple myeloma, including RSK2. Blood 125:483-91 (2015). PubMed: 25395420
  • Gajula RP  et al. Structure-function studies of the bHLH phosphorylation domain of TWIST1 in prostate cancer cells. Neoplasia 17:16-31 (2015). Human . PubMed: 25622896
  • Wen Z  et al. Evodiamine, a novel inhibitor of the Wnt pathway, inhibits the self-renewal of gastric cancer stem cells. Int J Mol Med 36:1657-63 (2015). PubMed: 26497016
  • Flatley E  et al. Aberrations of MYC are a common event in B-cell prolymphocytic leukemia. Am J Clin Pathol 142:347-54 (2014). PubMed: 25125625
  • Kim JS  et al. The prostate cancer TMPRSS2:ERG fusion synergizes with the vitamin D receptor (VDR) to induce CYP24A1 expression-limiting VDR signaling. Endocrinology 155:3262-73 (2014). WB ; Human . PubMed: 24926821
  • Sabò A  et al. Selective transcriptional regulation by Myc in cellular growth control and lymphomagenesis. Nature 511:488-92 (2014). WB . PubMed: 25043028
  • Wiegering A  et al. E7080 (lenvatinib), a multi-targeted tyrosine kinase inhibitor, demonstrates antitumor activities against colorectal cancer xenografts. Neoplasia 16:972-81 (2014). WB ; Human . PubMed: 25425971
  • Huang W  et al. C-MYC overexpression predicts aggressive transformation and a poor outcome in mucosa-associated lymphoid tissue lymphomas. Int J Clin Exp Pathol 7:5634-44 (2014). IHC ; Human . PubMed: 25337204
  • Guo H  et al. Post-translational glycoprotein modifications regulate colon cancer stem cells and colon adenoma progression in Apc(min/+) mice through altered Wnt receptor signaling. J Biol Chem 289:31534-49 (2014). PubMed: 25274627
  • Miyata-Takata T  et al. A case of diffuse large B-cell lymphoma transformed from primary duodenal follicular lymphoma. Pathol Int 64:527-32 (2014). PubMed: 25186289
  • Popovic R  et al. Histone methyltransferase MMSET/NSD2 alters EZH2 binding and reprograms the myeloma epigenome through global and focal changes in H3K36 and H3K27 methylation. PLoS Genet 10:e1004566 (2014). WB ; Human . PubMed: 25188243
  • Harashima N  et al. Transfection of poly(I:C) can induce reactive oxygen species-triggered apoptosis and interferon-ß-mediated growth arrest in human renal cell carcinoma cells via innate adjuvant receptors and the 2-5A system. Mol Cancer 13:217 (2014). PubMed: 25227113
  • Turakhia SK  et al. Aggressive B-cell lymphomas with translocations involving BCL6 and MYC have distinct clinical-pathologic characteristics. Am J Clin Pathol 142:339-46 (2014). PubMed: 25125624
  • Molina TJ  et al. Young patients with non-germinal center B-cell-like diffuse large B-cell lymphoma benefit from intensified chemotherapy with ACVBP plus rituximab compared with CHOP plus rituximab: analysis of data from the Groupe d'Etudes des Lymphomes de l'Adulte/lymphoma study association phase III trial LNH 03-2B. J Clin Oncol 32:3996-4003 (2014). IHC-P ; Human . PubMed: 25385729
  • Ferrari de Andrade L  et al. Natural killer cells are essential for the ability of BRAF inhibitors to control BRAFV600E-mutant metastatic melanoma. Cancer Res 74:7298-308 (2014). WB ; Mouse . PubMed: 25351955
  • Saborowski M  et al. A modular and flexible ESC-based mouse model of pancreatic cancer. Genes Dev 28:85-97 (2014). WB ; Mouse . PubMed: 24395249
  • Toon CW  et al. Immunohistochemistry for myc predicts survival in colorectal cancer. PLoS One 9:e87456 (2014). IHC-P ; Human . PubMed: 24503701
  • Cho H  et al. RapidCaP, a novel GEM model for metastatic prostate cancer analysis and therapy, reveals myc as a driver of Pten-mutant metastasis. Cancer Discov 4:318-33 (2014). PubMed: 24444712
  • Sanz-Moreno A  et al. Miz1 deficiency in the mammary gland causes a lactation defect by attenuated Stat5 expression and phosphorylation. PLoS One 9:e89187 (2014). IF, IHC ; Mouse . PubMed: 24586582
  • Xie Y  et al. p53 expression is a strong marker of inferior survival in de novo diffuse large B-cell lymphoma and may have enhanced negative effect with MYC coexpression: a single institutional clinicopathologic study. Am J Clin Pathol 141:593-604 (2014). Human . PubMed: 24619762
  • Qi WL  et al. Involvement of RbAp48 in erythroid differentiation of murine erythroleukemia cells induced by sodium butyrate. Oncol Lett 7:1785-1789 (2014). WB ; Human . PubMed: 24932233
  • van der Meer R  et al. RNAi screen identifies a synthetic lethal interaction between PIM1 overexpression and PLK1 inhibition. Clin Cancer Res 20:3211-21 (2014). PubMed: 24771642
  • Farrell AS  et al. Targeting inhibitors of the tumor suppressor PP2A for the treatment of pancreatic cancer. Mol Cancer Res 12:924-39 (2014). WB, ChIP . PubMed: 24667985
  • Janghorban M  et al. Targeting c-MYC by antagonizing PP2A inhibitors in breast cancer. Proc Natl Acad Sci U S A 111:9157-62 (2014). ChIP . PubMed: 24927563
  • Bellas C  et al. Immunohistochemical and molecular characteristics with prognostic significance in diffuse large B-cell lymphoma. PLoS One 9:e98169 (2014). IHC-P ; Human . PubMed: 24887414
  • Smith SC  et al. CIC-DUX sarcomas demonstrate frequent MYC amplification and ETS-family transcription factor expression. Mod Pathol N/A:N/A (2014). PubMed: 24947144
  • Simeone P  et al. A unique four-hub protein cluster associates to glioblastoma progression. PLoS One 9:e103030 (2014). IHC-P ; Human . PubMed: 25050814
  • Yan LX  et al. MYC expression in concert with BCL2 and BCL6 expression predicts outcome in Chinese patients with diffuse large B-cell lymphoma, not otherwise specified. PLoS One 9:e104068 (2014). IHC-P ; Human . PubMed: 25090026
  • Ceribelli M  et al. Blockade of oncogenic I?B kinase activity in diffuse large B-cell lymphoma by bromodomain and extraterminal domain protein inhibitors. Proc Natl Acad Sci U S A 111:11365-70 (2014). WB . PubMed: 25049379
  • Diefenbacher ME  et al. The deubiquitinase USP28 controls intestinal homeostasis and promotes colorectal cancer. J Clin Invest 124:3407-18 (2014). WB ; Human . PubMed: 24960159
  • Wang B  et al. N-myc downstream regulated gene 1 acts as a tumor suppressor in ovarian cancer. Oncol Rep 31:2279-85 (2014). PubMed: 24626771
  • Lynch JT  et al. TTC5 is required to prevent apoptosis of acute myeloid leukemia stem cells. Cell Death Dis 4:e573 (2013). WB, IP ; Human . PubMed: 23559008
  • Horn H  et al. MYC status in concert with BCL2 and BCL6 expression predicts outcome in diffuse large B-cell lymphoma. Blood 121:2253-63 (2013). ICC ; Human . PubMed: 23335369
  • Lin WC  et al. Dormant cancer cells contribute to residual disease in a model of reversible pancreatic cancer. Cancer Res 73:1821-30 (2013). PubMed: 23467612
  • Valera A  et al. ALK-positive large B-cell lymphomas express a terminal B-cell differentiation program and activated STAT3 but lack MYC rearrangements. Mod Pathol N/A:N/A (2013). Human . PubMed: 23599149
  • Padmanabhan A  et al. Protein kinase A regulates MYC protein through transcriptional and post-translational mechanisms in a catalytic subunit isoform-specific manner. J Biol Chem 288:14158-69 (2013). WB . PubMed: 23504319
  • Hu S  et al. MYC/BCL2 protein coexpression contributes to the inferior survival of activated B-cell subtype of diffuse large B-cell lymphoma and demonstrates high-risk gene expression signatures: a report from The International DLBCL Rituximab-CHOP Consortium Program. Blood 121:4021-31; quiz 4250 (2013). IHC-P ; Human . PubMed: 23449635
  • Sancho M  et al. Competitive interactions eliminate unfit embryonic stem cells at the onset of differentiation. Dev Cell 26:19-30 (2013). IHC-P . PubMed: 23867226
  • Yi T  et al. Hypoxia-inducible factor-1a (HIF-1a) promotes cap-dependent translation of selective mRNAs through up-regulating initiation factor eIF4E1 in breast cancer cells under hypoxia conditions. J Biol Chem 288:18732-42 (2013). Mouse . PubMed: 23667251
  • Pourdehnad M  et al. Myc and mTOR converge on a common node in protein synthesis control that confers synthetic lethality in Myc-driven cancers. Proc Natl Acad Sci U S A 110:11988-93 (2013). IHC ; Mouse . PubMed: 23803853
  • Chaux A  et al. Dysregulation of the mammalian target of rapamycin pathway in chromophobe renal cell carcinomas. Hum Pathol 44:2323-30 (2013). Human . PubMed: 23953228
  • Hatano K  et al. Residual prostate cancer cells after docetaxel therapy increase the tumorigenic potential via constitutive signaling of CXCR4, ERK1/2 and c-Myc. Mol Cancer Res 11:1088-100 (2013). PubMed: 23788635
  • Rubenstein JL  et al. Intensive chemotherapy and immunotherapy in patients with newly diagnosed primary CNS lymphoma: CALGB 50202 (Alliance 50202). J Clin Oncol 31:3061-8 (2013). Human . PubMed: 23569323
  • Munari E  et al. Dysregulation of mammalian target of rapamycin pathway in upper tract urothelial carcinoma. Hum Pathol N/A:N/A (2013). IHC-P ; Human . PubMed: 24074531
  • Pham-Ledard A  et al. Multiple genetic alterations in primary cutaneous large B-cell lymphoma, leg type support a common lymphomagenesis with activated B-cell-like diffuse large B-cell lymphoma. Mod Pathol N/A:N/A (2013). Human . PubMed: 24030746
  • Wang LS  et al. Dietary black raspberries modulate DNA methylation in dextran sodium sulfate (DSS)-induced ulcerative colitis. Carcinogenesis N/A:N/A (2013). IHC ; Mouse . PubMed: 24067901
  • Valentino C  et al. Colorimetric in situ hybridization identifies MYC gene signal clusters correlating with increased copy number, mRNA, and protein in diffuse large B-cell lymphoma. Am J Clin Pathol 139:242-54 (2013). IHC-P ; Human . PubMed: 23355209
  • Rosales T  et al. Partition of Myc into immobile vs. mobile complexes within nuclei. Sci Rep 3:1953 (2013). WB . PubMed: 23739641
  • Gurung B  et al. Menin directly represses gli1 expression independent of canonical hedgehog signaling. Mol Cancer Res 11:1215-22 (2013). WB . PubMed: 23928057
  • Chen S  et al. Mechanistic studies for the role of cellular nucleic-acid-binding protein (CNBP) in regulation of c-myc transcription. Biochim Biophys Acta 1830:4769-77 (2013). WB ; Human . PubMed: 23774591
  • Valera A  et al. MYC protein expression and genetic alterations have prognostic impact in patients with diffuse large B-cell lymphoma treated with immunochemotherapy. Haematologica 98:1554-62 (2013). IHC, ICC/IF ; Human . PubMed: 23716551
  • Olive V  et al. A component of the mir-17-92 polycistronic oncomir promotes oncogene-dependent apoptosis. Elife 2:e00822 (2013). WB ; Mouse . PubMed: 24137534
  • Tzankov A  et al. Rearrangements of MYC gene facilitate risk stratification in diffuse large B-cell lymphoma patients treated with rituximab-CHOP. Mod Pathol N/A:N/A (2013). Human . PubMed: 24336156
  • Sanchez-Arévalo Lobo VJ  et al. Dual regulation of Myc by Abl. Oncogene 32:5261-71 (2013). PubMed: 23318434
  • Gajula RP  et al. The twist box domain is required for Twist1-induced prostate cancer metastasis. Mol Cancer Res 11:1387-400 (2013). PubMed: 23982216
  • Chao C  et al. Epstein-Barr virus infection and expression of B-cell oncogenic markers in HIV-related diffuse large B-cell Lymphoma. Clin Cancer Res 18:4702-12 (2012). IHC-P ; Human . PubMed: 22711707
  • Kluk MJ  et al. Immunohistochemical detection of MYC-driven diffuse large B-cell lymphomas. PLoS One 7:e33813 (2012). IHC-P ; Human . PubMed: 22511926
  • Lehmann FM  et al. Humanized c-Myc mouse. PLoS One 7:e42021 (2012). WB ; Human . PubMed: 22860051
  • Tudor CS  et al. c-Myc and EBV-LMP1: two opposing regulators of the HLA class I antigen presentation machinery in epithelial cells. Br J Cancer 106:1980-8 (2012). WB ; Human . PubMed: 22588558
  • Marzi MJ  et al. Differentiation-associated microRNAs antagonize the Rb-E2F pathway to restrict proliferation. J Cell Biol 199:77-95 (2012). WB . PubMed: 23027903
  • Neff T  et al. Polycomb repressive complex 2 is required for MLL-AF9 leukemia. Proc Natl Acad Sci U S A 109:5028-33 (2012). WB . PubMed: 22396593
  • Zhang X  et al. Mechanistic insight into Myc stabilization in breast cancer involving aberrant Axin1 expression. Proc Natl Acad Sci U S A 109:2790-5 (2012). WB ; Human . PubMed: 21808024
  • Kim CW  et al. Ectopic over-expression of tristetraprolin in human cancer cells promotes biogenesis of let-7 by down-regulation of Lin28. Nucleic Acids Res 40:3856-69 (2012). WB . PubMed: 22210895
  • Ji H  et al. Cell-type independent MYC target genes reveal a primordial signature involved in biomass accumulation. PLoS One 6:e26057 (2011). PubMed: 22039435
  • Karst AM  et al. Modeling high-grade serous ovarian carcinogenesis from the fallopian tube. Proc Natl Acad Sci U S A 108:7547-52 (2011). PubMed: 21502498
  • Scholer-Dahirel A  et al. Maintenance of adenomatous polyposis coli (APC)-mutant colorectal cancer is dependent on Wnt/{beta}-catenin signaling. Proc Natl Acad Sci U S A 108:17135-40 (2011). IHC-P ; Human . PubMed: 21949247
  • Bruning U  et al. MicroRNA-155 promotes resolution of hypoxia-inducible factor 1alpha activity during prolonged hypoxia. Mol Cell Biol 31:4087-96 (2011). PubMed: 21807897
  • Lorenz A  et al. Severe alterations of cerebellar cortical development after constitutive activation of wnt signaling in granule neuron precursors. Mol Cell Biol 31:3326-38 (2011). IHC-P ; Mouse . PubMed: 21690300
  • Steininger A  et al. Genomic loss of the putative tumor suppressor gene E2A in human lymphoma. J Exp Med 208:1585-93 (2011). IHC-P ; Human . PubMed: 21788410
  • Seitz V  et al. Deep Sequencing of MYC DNA-Binding Sites in Burkitt Lymphoma. PLoS One 6:e26837 (2011). WB ; Human . PubMed: 22102868
  • Challagundla KB  et al. Ribosomal protein L11 recruits miR-24/miRISC to repress c-Myc expression in response to ribosomal stress. Mol Cell Biol 31:4007-21 (2011). Human . PubMed: 21807902
  • Pagán B  et al. Erlotinib inhibits progression to dysplasia in a colitis-associated colon cancer model. World J Gastroenterol 17:4858-66 (2011). IHC-P ; Rat . PubMed: 22171126
  • Ren Y  et al. Critical role of Shp2 in tumor growth involving regulation of c-Myc. Genes Cancer 1:994-1007 (2010). IHC-P ; Human . PubMed: 21442024
  • Escamilla-Powers JR  et al. The tumor suppressor protein HBP1 is a novel c-myc-binding protein that negatively regulates c-myc transcriptional activity. J Biol Chem 285:4847-58 (2010). IP ; Human . PubMed: 20008325
  • Rohan JN & Weigel NL 1Alpha,25-dihydroxyvitamin D3 reduces c-Myc expression, inhibiting proliferation and causing G1 accumulation in C4-2 prostate cancer cells. Endocrinology 150:2046-54 (2009). PubMed: 19164469
  • Silva MM  et al. Characterization of reactive stroma in prostate cancer: involvement of growth factors, metalloproteinase matrix, sexual hormones receptors and prostatic stem cells. Int Braz J Urol 41:849-58 (0). PubMed: 26689510

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