C16 Ceramide (Palmitoyl ceramide), Endogenous ceramide (ab141747)

Overview

  • Product name

    C16 Ceramide (Palmitoyl ceramide), Endogenous ceramide
  • Description

    Endogenous ceramide
  • Biological description

    Endogenous ceramide. Various pharmacological activities. Activates protein kinase and induces phosphorylation of EGFR. Activates NF-kappaB and induces apoptosis. Active in vivo and in vitro.
  • Purity

    > 98%
  • CAS Number

    24696-26-2
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    N-(1,3-Dihydroxyoctadec-4-en-2-yl)hexadecanamide
  • Molecular weight

    537.90
  • Molecular formula

    C34H67NO3
  • PubChem identifier

    2498
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in ethanol with warming
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CCCCCCCCCCCCCCCC(=O)NC(CO)C(C=CCCCCCCCCCCCCC)O
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Aflaki E  et al. C16 ceramide is crucial for triacylglycerol-induced apoptosis in macrophages. Cell Death Dis 3:e280 (2012). Read more (PubMed: 22419109) »
  • Senkal CE  et al. Alteration of ceramide synthase 6/C16-ceramide induces activating transcription factor 6-mediated endoplasmic reticulum (ER) stress and apoptosis via perturbation of cellular Ca2+ and ER/Golgi membrane network. J Biol Chem 286:42446-58 (2011). Read more (PubMed: 22013072) »
  • Osawa Y  et al. Roles for C16-ceramide and sphingosine 1-phosphate in regulating hepatocyte apoptosis in response to tumor necrosis factor-alpha. J Biol Chem 280:27879-87 (2005). Read more (PubMed: 15946935) »

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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