Biotin Anti-C1q antibody (ab48341)
Key features and details
- Biotin Rabbit polyclonal to C1q
- Suitable for: RIA, WB
- Reacts with: Human
- Conjugation: Biotin
- Isotype: IgG
Overview
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Product name
Biotin Anti-C1q antibody
See all C1q primary antibodies -
Description
Biotin Rabbit polyclonal to C1q -
Host species
Rabbit -
Conjugation
Biotin -
Tested applications
Suitable for: RIA, WBmore details -
Species reactivity
Reacts with: Human -
Immunogen
Human C1q purified from Human plasma.
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
Storage buffer
pH: 7.40
Preservative: 0.02% Sodium azide
Constituents: 49.73% PBS, 50% Glycerol (glycerin, glycerine), 0.25% BSA -
Concentration information loading...
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Purity
Protein G purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Isotype control
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab48341 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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RIA |
Use at an assay dependent concentration.
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WB |
Use at an assay dependent concentration.
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Notes |
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RIA
Use at an assay dependent concentration. |
WB
Use at an assay dependent concentration. |
Target
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Function
C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes. -
Involvement in disease
Defects in C1QA are a cause of complement component C1q deficiency (C1QD) [MIM:613652]. A rare defect resulting in C1 deficiency and impaired activation of the complement classical pathway. C1 deficiency generally leads to severe immune complex disease with features of systemic lupus erythematosus and glomerulonephritis. -
Sequence similarities
Contains 1 C1q domain.
Contains 1 collagen-like domain. -
Post-translational
modificationsO-linked glycans consist of Glc-Gal disaccharides bound to the oxygen atom of post-translationally added hydroxyl groups. -
Cellular localization
Secreted. - Information by UniProt
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Database links
- Entrez Gene: 712 Human
- Entrez Gene: 713 Human
- Entrez Gene: 714 Human
- Omim: 120550 Human
- Omim: 120570 Human
- Omim: 120575 Human
- SwissProt: P02745 Human
- SwissProt: P02746 Human
see all -
Alternative names
- C1qa antibody
- C1QA_HUMAN antibody
- C1QB antibody
see all
Datasheets and documents
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SDS download
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Datasheet download
References (0)
ab48341 has not yet been referenced specifically in any publications.