• Product name
    Anti-C1q antibody (HRP)
    See all C1q primary antibodies
  • Description
    Sheep polyclonal to C1q (HRP)
  • Host species
  • Conjugation
  • Tested applications
    Suitable for: ELISAmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Human C1q



Our Abpromise guarantee covers the use of ab46191 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ELISA 1/100 - 1/400.


  • Function
    C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes.
  • Involvement in disease
    Defects in C1QA are a cause of complement component C1q deficiency (C1QD) [MIM:613652]. A rare defect resulting in C1 deficiency and impaired activation of the complement classical pathway. C1 deficiency generally leads to severe immune complex disease with features of systemic lupus erythematosus and glomerulonephritis.
  • Sequence similarities
    Contains 1 C1q domain.
    Contains 1 collagen-like domain.
  • Post-translational
    O-linked glycans consist of Glc-Gal disaccharides bound to the oxygen atom of post-translationally added hydroxyl groups.
  • Cellular localization
  • Information by UniProt
  • Database links
  • Alternative names
    • C1qa antibody
    • C1QA_HUMAN antibody
    • C1QB antibody
    • C1QC antibody
    • Complement C1q subcomponent subunit A antibody
    • Complement C1q subcomponent subunit B antibody
    • Complement C1q subcomponent subunit C antibody
    • Complement component 1 q subcomponent alpha polypeptide antibody
    • Complement component C1q A chain antibody
    • Complement component C1q B chain antibody
    • Complement component C1q C chain antibody
    see all


This product has been referenced in:
  • Klaus T & Bereta J CH2 Domain of Mouse IgG3 Governs Antibody Oligomerization, Increases Functional Affinity to Multivalent Antigens and Enhances Hemagglutination. Front Immunol 9:1096 (2018). Read more (PubMed: 29875771) »
  • Rasche L  et al. The natural human IgM antibody PAT-SM6 induces apoptosis in primary human multiple myeloma cells by targeting heat shock protein GRP78. PLoS One 8:e63414 (2013). ELISA ; Human . Read more (PubMed: 23667612) »

See all 6 Publications for this product

Customer reviews and Q&As

Thank you for contacting Abcam regarding ab46191.

I have looked into the various lots you have used and there have been no changes in the formulations, concentrations, or QC results. Because this is a polyclonal antibody, some lot-to-lot ...

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Thank you for contacting us.

Please find attached the CoC certificate with this email.

I hope this information is helpful to you. Please do not hesitate to contact us if you need any more advice or information.

Use our ...

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We don't do CoAs, and we state this in our FAQs: "Some of our collaborators are not certified ISO9001 and so we are not able to provide a certificate of analysis for these particular products."

However, we offer the following "As the identity...

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Thank you very much for your email.

I am sorry we don't' have explanation why the antibody gave good results when stored at -80C than 4C. Generally the antibodies are viable for months at 4C and storingthem at 4C, for couple of weeks, should ...

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Thank you for contacting us. I am sorry to hear that you are experiencing problems with this antibody.

We changed the storage conditions of this product to ‘4 deg C do not freeze’ back in 201. This was because the buffer now inclu...

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Thank you for your enquiry.

I can confirm that this antibodyshouldnot to be frozen but stored at +4C.

We do not have set expiration dates for our products. Most antibodies are stable and can last for anywhere from a few months to s...

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Thank you for contacting us. I received the following information from the supplying lab: The detailed information regarding the specifics of the immunogen (e.g. is the immunogen composed of all 3 C1q subunits A, B and C or just one of them?) ar...

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