Overview

  • Product name

    Anti-C1s antibody [EPR9067(B)]
    See all C1s primary antibodies
  • Description

    Rabbit monoclonal [EPR9067(B)] to C1s
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WBmore details
    Unsuitable for: IHC-P
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Synthetic peptide within Human C1s aa 600-700. The exact sequence is proprietary.

  • Positive control

    • Human platelet and Human serum lysate.
  • General notes

    Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species. Please contact us for more information.

     

    Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMab® patents.

    This product is a recombinant rabbit monoclonal antibody.

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • Dissociation constant (KD)

    KD = 3.04 x 10 -11 M
    Learn more about KD
  • Storage buffer

    Preservative: 0.01% Sodium azide
    Constituents: 9% PBS, 40% Glycerol, 0.05% BSA, 50% Tissue culture supernatant
  • Purity

    Tissue culture supernatant
  • Clonality

    Monoclonal
  • Clone number

    EPR9067(B)
  • Isotype

    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab134928 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use at an assay dependent concentration. Predicted molecular weight: 77 kDa.
  • Application notes
    Is unsuitable for IHC-P.
  • Target

    • Function

      C1s B chain is a serine protease that combines with C1q and C1s to form C1, the first component of the classical pathway of the complement system. C1r activates C1s so that it can, in turn, activate C2 and C4.
    • Involvement in disease

      Defects in C1S are the cause of complement component C1s deficiency (C1SD) [MIM:613783]. A rare defect resulting in C1 deficiency and impaired activation of the complement classical pathway. C1 deficiency generally leads to severe immune complex disease with features of systemic lupus erythematosus and glomerulonephritis.
    • Sequence similarities

      Belongs to the peptidase S1 family.
      Contains 2 CUB domains.
      Contains 1 EGF-like domain.
      Contains 1 peptidase S1 domain.
      Contains 2 Sushi (CCP/SCR) domains.
    • Post-translational
      modifications

      The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.
    • Information by UniProt
    • Database links

    • Alternative names

      • Basic proline rich peptide IB 1 antibody
      • C1 esterase antibody
      • C1S antibody
      • C1S_HUMAN antibody
      • Complement C1s subcomponent antibody
      • Complement C1s subcomponent heavy chain antibody
      • Complement C1s subcomponent light chain antibody
      • Complement component 1 s subcomponent antibody
      • Complement component 1 subcomponent s antibody
      • FLJ44757 antibody
      see all

    Images

    • All lanes : Anti-C1s antibody [EPR9067(B)] (ab134928) at 1/1000 dilution

      Lane 1 : Human platelet lysate
      Lane 2 : Human serum lysate

      Lysates/proteins at 10 µg per lane.

      Secondary
      All lanes : Goat-anti-rabbit HRP at 1/2000 dilution

      Predicted band size: 77 kDa

    • Equilibrium disassociation constant (KD)
      Learn more about KD

      Click here to learn more about KD

    References

    ab134928 has not yet been referenced specifically in any publications.

    Customer reviews and Q&As

    There are currently no Customer reviews or Questions for ab134928.
    Please use the links above to contact us or submit feedback about this product.

    Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
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