Key features and details
- Mouse monoclonal [6E3] to C2
- Reacts with: Human
- Isotype: IgG1
Product nameAnti-C2 antibody [6E3]
See all C2 primary antibodies
DescriptionMouse monoclonal [6E3] to C2
SpecificityStrong reaction is seen with human serum/plasma and no reaction is seen with serum from patients deficient in C2. ab17452 reacts with C2 and a subfraction of C2 believed to be C2b.
Species reactivityReacts with: Human
Full length native complement component C2 protein, isolated from human plasma.
EpitopeEpitope specificity differs from that of ab17451 as determined by inhibition ELISA.
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Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Storage bufferpH: 7.40
Preservative: 0.097% Sodium azide
Constituents: 0.0268% PBS, 2.9% Sodium chloride
Concentration information loading...
PurityProtein G purified
Light chain typekappa
WB: 1/250. Predicted molecular weight: 102 kDa. ab17452 reacts with C2 under reducing and non-reducing conditions.
Not tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
FunctionComponent C2 which is part of the classical pathway of the complement system is cleaved by activated factor C1 into two fragments: C2b and C2a. C2a, a serine protease, then combines with complement factor 4b to generate the C3 or C5 convertase.
Involvement in diseaseDefects in C2 are the cause of complement component 2 deficiency (C2D) [MIM:217000]. A deficiency of the complement classical pathway associated with the development of autoimmune disorders, mainly systemic lupus erythematosus. Skin and joint manifestations are common and renal disease is relatively rare. Patients with complement component 2 deficiency are also reported to have recurrent or invasive infections.
Sequence similaritiesBelongs to the peptidase S1 family.
Contains 1 peptidase S1 domain.
Contains 3 Sushi (CCP/SCR) domains.
Contains 1 VWFA domain.
- Information by UniProt
- ARMD14 antibody
- C2 antibody
- C3/C5 convertase antibody
ab17452 has been referenced in 1 publication.
- Martini PG et al. Recombinant human complement component C2 produced in a human cell line restores the classical complement pathway activity in-vitro: an alternative treatment for C2 deficiency diseases. BMC Immunol 11:43 (2010). Sandwich ELISA ; Human . PubMed: 20727163