Product nameAnti-C2 antibody
See all C2 primary antibodies
DescriptionRabbit polyclonal to C2
Tested applicationsSuitable for: Double Immunodiffusion, Immunodiffusion, IPmore details
Species reactivityReacts with: Human
Predicted to work with: Chimpanzee, Gorilla
Full length native protein (purified) corresponding to Human C2 aa 21-752.
APSCPQNVNISGGTFTLSHGWAPGSLLTYSCPQGLYPSPASRLCKSSGQW QTPGATRSLSKAVCKPVRCPAPVSFENGIYTPRLGSYPVGGNVSFECEDG FILRGSPVRQCRPNGMWDGETAVCDNGAGHCPNPGISLGAVRTGFRFGHG DKVRYRCSSNLVLTGSSERECQGNGVWSGTEPICRQPYSYDFPEDVAPAL GTSFSHMLGATNPTQKTKESLGRKIQIQRSGHLNLYLLLDCSQSVSENDF LIFKESASLMVDRIFSFEINVSVAIITFASEPKVLMSVLNDNSRDMTEVI SSLENANYKDHENGTGTNTYAALNSVYLMMNNQMRLLGMETMAWQEIRHA IILLTDGKSNMGGSPKTAVDHIREILNINQKRNDYLDIYAIGVGKLDVDW RELNELGSKKDGERHAFILQDTKALHQVFEHMLDVSKLTDTICGVGNMSA NASDQERTPWHVTIKPKSQETCRGALISDQWVLTAAHCFRDGNDHSLWRV NVGDPKSQWGKEFLIEKAVISPGFDVFAKKNQGILEFYGDDIALLKLAQK VKMSTHARPICLPCTMEANLALRRPQGSTCRDHENELLNKQSVPAHFVAL NGSKLNINLKMGVEWTSCAEVVSQEKTMFPNLTDVREVVTDQFLCSGTQE DESPCKGESGGAVFLERRFRFFQVGLVSWGLYNPCLGSADKNSRKRAPRS KVPPPRDFHINLFRMQPWLRQHLGDVLNFLPL
Database link: P06681
- Human plasma.
FormLyophilised:Reconstitute the lyophilized antiserum by adding 1 ml sterile distilled water. Dilutions may be prepared by adding phosphate buffered saline (PBS, pH 7.2). If a slight precipitation occurs upon storage, this should be removed by centrifugation. It will not affect the performance of the antiserum.
Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
Storage bufferConstituents: 99% PBS, EDTA
No preservative added. No foreign proteins added.
Concentration information loading...
Purification notesDelipidated, heat inactivated, stable IgG fraction.
Our Abpromise guarantee covers the use of ab182961 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|Double Immunodiffusion||Use at an assay dependent concentration.
In double radial immunodiffusion use a rosette arrangement with 10 μl antiserum in 3 mm diameter center well and 2 μl plasma samples (neat and serially diluted) in 2 mm diameter peripheral wells.
|Immunodiffusion||Use at an assay dependent concentration.
Precipitin titre not less than 1/32 when tested against appropriate concentrations of purified C2 protein in agar-block immunodiffusion titration.
|IP||Use at an assay dependent concentration.|
FunctionComponent C2 which is part of the classical pathway of the complement system is cleaved by activated factor C1 into two fragments: C2b and C2a. C2a, a serine protease, then combines with complement factor 4b to generate the C3 or C5 convertase.
Involvement in diseaseDefects in C2 are the cause of complement component 2 deficiency (C2D) [MIM:217000]. A deficiency of the complement classical pathway associated with the development of autoimmune disorders, mainly systemic lupus erythematosus. Skin and joint manifestations are common and renal disease is relatively rare. Patients with complement component 2 deficiency are also reported to have recurrent or invasive infections.
Sequence similaritiesBelongs to the peptidase S1 family.
Contains 1 peptidase S1 domain.
Contains 3 Sushi (CCP/SCR) domains.
Contains 1 VWFA domain.
- Information by UniProt
- ARMD14 antibody
- C2 antibody
- C3/C5 convertase antibody
ab182961 has not yet been referenced specifically in any publications.