Product nameAnti-C2 antibody
See all C2 primary antibodies
DescriptionRabbit polyclonal to C2
Tested applicationsSuitable for: WBmore details
Species reactivityReacts with: Human
Recombinant fragment, corresponding to a sequence within amino acids 265-612 of Human C2.
- 293T, A431, H1299, HeLaS3, HepG2, MOLT4 or Raji cell lysate.
Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Storage bufferpH: 7.00
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 1.21% Tris, 0.75% Glycine, 20% Glycerol
Concentration information loading...
PurityImmunogen affinity purified
Our Abpromise guarantee covers the use of ab97461 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|WB||1/500 - 1/3000. Predicted molecular weight: 83 kDa.|
FunctionComponent C2 which is part of the classical pathway of the complement system is cleaved by activated factor C1 into two fragments: C2b and C2a. C2a, a serine protease, then combines with complement factor 4b to generate the C3 or C5 convertase.
Involvement in diseaseDefects in C2 are the cause of complement component 2 deficiency (C2D) [MIM:217000]. A deficiency of the complement classical pathway associated with the development of autoimmune disorders, mainly systemic lupus erythematosus. Skin and joint manifestations are common and renal disease is relatively rare. Patients with complement component 2 deficiency are also reported to have recurrent or invasive infections.
Sequence similaritiesBelongs to the peptidase S1 family.
Contains 1 peptidase S1 domain.
Contains 3 Sushi (CCP/SCR) domains.
Contains 1 VWFA domain.
- Information by UniProt
- ARMD14 antibody
- C2 antibody
- C3/C5 convertase antibody
All lanes : Anti-C2 antibody (ab97461) at 1/1000 dilution
Lane 1 : 293T
whole cell lysate
Lane 2 : A431 whole cell lysate
Lane 3 : H1299
whole cell lysate
Lane 4 : HeLa S3 whole cell lysate
Lane 5 : Hep G2 whole cell lysate
Lane 6 : MOLT4 whole cell lysate
Lane 7 : Raji whole cell lysate
Lysates/proteins at 30 µg per lane.
Predicted band size: 83 kDa
ab97461 has not yet been referenced specifically in any publications.