C2-Phytoceramide, Ceramide-activated protein phosphatase activator (ab141752)

Overview

  • Product name

    C2-Phytoceramide, Ceramide-activated protein phosphatase activator
  • Description

    Ceramide-activated protein phosphatase activator
  • Biological description

    Ceramide-activated protein phosphatase (CAPP) activator. Inhibits cell growth and induces apoptosis. Shows cytotoxic effects in vitro. Modulates the mAChR-mediated signal transduction pathway.
  • Purity

    > 98%
  • CAS Number

    475995-69-8
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    N-[(2S,3S,4R)-1,3,4-Trihydroxyoctadecan-2-yl]acetamide
  • Molecular weight

    359.54
  • Molecular formula

    C20H41NO4
  • PubChem identifier

    9798946
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 50 mM and in ethanol to 50 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CCCCCCCCCCCCCCC(C(C(CO)NC(=O)C)O)O
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Lee JS  et al. Phytosphingosine and C2-phytoceramide induce cell death and inhibit carbachol-stimulated phospholipase D activation in Chinese hamster ovary cells expressing the Caenorhabditis elegans muscarinic acetylcholine receptor. FEBS Lett 499:82-6 (2001). Read more (PubMed: 11418117) »
  • Bielawska A  et al. Selectivity of ceramide-mediated biology. Lack of activity of erythro-dihydroceramide. J Biol Chem 268:26226-32 (1993). Read more (PubMed: 8253743) »
  • Fishbein JD  et al. Ceramide-mediated growth inhibition and CAPP are conserved in Saccharomyces cerevisiae. J Biol Chem 268:9255-61 (1993). Read more (PubMed: 8387486) »

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