• Product name

  • Description

    Rabbit polyclonal to C5
  • Host species

  • Tested applications

    Suitable for: IHC-FoFr, WB, IHC-Frmore details
  • Species reactivity

    Reacts with: Mouse
    Does not react with: Human
  • Immunogen

    Recombinant protein from E.coli. The exact sequence information is considered to be commercially sensitive.

  • Positive control

    • liver tissues (hepatocytes)



Our Abpromise guarantee covers the use of ab11898 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-FoFr Use at an assay dependent concentration. PubMed: 19541934
WB 1/10. Predicted molecular weight: 188.9 kDa.
IHC-Fr 1/10.


  • Function

    Activation of C5 by a C5 convertase initiates the spontaneous assembly of the late complement components, C5-C9, into the membrane attack complex. C5b has a transient binding site for C6. The C5b-C6 complex is the foundation upon which the lytic complex is assembled.
    Derived from proteolytic degradation of complement C5, C5 anaphylatoxin is a mediator of local inflammatory process. It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes. C5a also stimulates the locomotion of polymorphonuclear leukocytes (chemokinesis) and direct their migration toward sites of inflammation (chemotaxis).
  • Involvement in disease

    Defects in C5 are the cause of complement component 5 deficiency (C5D) [MIM:609536]. A rare defect of the complement classical pathway associated with susceptibility to severe recurrent infections, predominantly by Neisseria gonorrhoeae or Neisseria meningitidis.
    Note=An association study of C5 haplotypes and genotypes in individuals with chronic hepatitis C virus infection shows that individuals homozygous for the C5_1 haplotype have a significantly higher stage of liver fibrosis than individuals carrying at least 1 other allele (PubMed:15995705).
  • Sequence similarities

    Contains 1 anaphylatoxin-like domain.
    Contains 1 NTR domain.
  • Cellular localization

  • Information by UniProt
  • Database links

  • Alternative names

    • Anaphylatoxin C5a analog antibody
    • C3 and PZP-like alpha-2-macroglobulin domain-containing protein 4 antibody
    • C5 antibody
    • C5a anaphylatoxin antibody
    • C5a antibody
    • C5b antibody
    • CO5_HUMAN antibody
    • Complement C5 alpha'' chain antibody
    • Complement C5 antibody
    • Complement component C5 antibody
    • CPAMD4 antibody
    • prepro-C5 antibody
    see all


This product has been referenced in:

  • Yin C  et al. ApoE attenuates unresolvable inflammation by complex formation with activated C1q. Nat Med 25:496-506 (2019). Read more (PubMed: 30692699) »
  • Arbore G  et al. Complement receptor CD46 co-stimulates optimal human CD8+ T cell effector function via fatty acid metabolism. Nat Commun 9:4186 (2018). Read more (PubMed: 30305631) »
See all 3 Publications for this product

Customer reviews and Q&As

1-4 of 4 Abreviews or Q&A


Thank you for contacting us.

The C5 antibody ab11898 has not, to our knowledge, been tested in a neutralization assay.

The antibody is purified over a protein G column to separate immunoglobulin from other proteins.

I hope this information is helpful to you. Please do not hesitate to contact us if you need any more advice or information.

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Thank you very much for your reply, and I apologize that I did not mention the details of ab11898.

This antibody has not been tested in our labs in IHC or for reactivity with the mouse protein, so we do not have a specific dilution or concentration to recommend for your assay. IHC was added to our datasheet due to feedback in literature showing that the antibody is suitable for this application, though I could not find a reference for the 1:10 recommended dilution. Since we are not sure whether the antibody will cross-react with rat samples, I would recommend using the ab33948 antibody that we discussed previoiusly.

I hope this information will be useful, but please let me know if you have any further questions and I'll be happy to help.

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Thank you for your enquiry. For ab11898, the antibody should recognize the whole mouse C5 chain; since this is a polyclonal antibody it is very likely that it recognizes both C5a and C5b. As the sequence of the immunogen used is commercially sensitive, we can't guarantee this however. For ab17930 and ab17457, the antibodies only recognize non-reduced C5 where the molecule is not split into its component subunit chains. The antibodies are expected to recognize an epitope on the interface between the different subunits, though that is purely speculation. All three antibodies are £ 198.00. Please contact us again if you have any additional questions.

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Thank you for your questions regarding ab11898. This antibody does not cross react with human C5. The polyclonal antibody was generated with recombinant human protein from E.coli. In our product range we have the following antibodies which cross react with human C5: ab11876: monoclonal antibody to human C5/C5a, clone 557. ab11877: monoclonal antibody to human C5/C5a, N-terminus, clone 561. ab11879: monoclonal antibody to human C5/C5b, clone 568. As positive control liver tissues (hepatocytes) can be used as the primary site of synthesis is the liver. Secondary sites are lung, spleen, fetal intestine, monocytes, macrophages and type II alveolar cells. I hope this information will be helpful to you. If you have further questions please do not hesitate to contact us.

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