Key features and details
- Rabbit polyclonal to C5
- Suitable for: WB, IHC-Fr
- Reacts with: Mouse
- Isotype: IgG
Product nameAnti-C5 antibody
See all C5 primary antibodies
DescriptionRabbit polyclonal to C5
Tested applicationsSuitable for: WB, IHC-Frmore details
Species reactivityReacts with: Mouse
Does not react with: Human
Recombinant protein from E.coli. The exact sequence information is considered to be commercially sensitive.
Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Storage bufferPreservative: 0.02% Sodium azide
Constituents: PBS, 0.1% BSA
Concentration information loading...
PurityProtein G purified
Our Abpromise guarantee covers the use of ab11898 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|WB||1/10. Predicted molecular weight: 188.9 kDa.|
FunctionActivation of C5 by a C5 convertase initiates the spontaneous assembly of the late complement components, C5-C9, into the membrane attack complex. C5b has a transient binding site for C6. The C5b-C6 complex is the foundation upon which the lytic complex is assembled.
Derived from proteolytic degradation of complement C5, C5 anaphylatoxin is a mediator of local inflammatory process. It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes. C5a also stimulates the locomotion of polymorphonuclear leukocytes (chemokinesis) and direct their migration toward sites of inflammation (chemotaxis).
Involvement in diseaseDefects in C5 are the cause of complement component 5 deficiency (C5D) [MIM:609536]. A rare defect of the complement classical pathway associated with susceptibility to severe recurrent infections, predominantly by Neisseria gonorrhoeae or Neisseria meningitidis.
Note=An association study of C5 haplotypes and genotypes in individuals with chronic hepatitis C virus infection shows that individuals homozygous for the C5_1 haplotype have a significantly higher stage of liver fibrosis than individuals carrying at least 1 other allele (PubMed:15995705).
Sequence similaritiesContains 1 anaphylatoxin-like domain.
Contains 1 NTR domain.
- Information by UniProt
- Anaphylatoxin C5a analog antibody
- C3 and PZP-like alpha-2-macroglobulin domain-containing protein 4 antibody
- C5 antibody
ab11898 has been referenced in 3 publications.
- Yin C et al. ApoE attenuates unresolvable inflammation by complex formation with activated C1q. Nat Med 25:496-506 (2019). PubMed: 30692699
- Arbore G et al. Complement receptor CD46 co-stimulates optimal human CD8+ T cell effector function via fatty acid metabolism. Nat Commun 9:4186 (2018). PubMed: 30305631
- Lundh von Leithner P et al. Complement factor h is critical in the maintenance of retinal perfusion. Am J Pathol 175:412-21 (2009). IHC-FoFr ; Mouse . PubMed: 19541934