Anti-C5a / C5a des Arg antibody [2952] (ab11878)
Key features and details
- Mouse monoclonal [2952] to C5a / C5a des Arg
- Suitable for: ELISA, IHC-Fr, Functional Studies, WB, IHC-P
- Reacts with: Human
- Isotype: IgG1
Get better batch-to-batch reproducibility with a recombinant antibody
- Research with confidence – consistent and reproducible results with every batch
- Long-term and scalable supply – powered by recombinant technology for fast production
- Success from the first experiment – confirmed specificity through extensive validation
- Ethical standards compliant – production is animal-free
Overview
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Product name
Anti-C5a / C5a des Arg antibody [2952]
See all C5a / C5a des Arg primary antibodies -
Description
Mouse monoclonal [2952] to C5a / C5a des Arg -
Host species
Mouse -
Specificity
This antibody reacts with a neo-epitope (des-Arg) on C5a that is formed upon cleavage of C5 into C5a and C5b. It will detect C5a and C5a des-Arg (Not C5).
Please notice that under given conditions it is known that C5 can expose epitopes normally only found in the cleaved activation products.
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Tested applications
Suitable for: ELISA, IHC-Fr, Functional Studies, WB, IHC-Pmore details -
Species reactivity
Reacts with: Human -
Immunogen
Other Immunogen Type. This information is proprietary to Abcam and/or its suppliers.
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Positive control
- Human Granulocytes
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
Storage buffer
Constituents: PBS, 0.1% BSA -
Concentration information loading... -
Purity
Protein G purified -
Purification notes
0.2 µm filtered -
Clonality
Monoclonal -
Clone number
2952 -
Isotype
IgG1 -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab11878 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| Application | Abreviews | Notes |
|---|---|---|
| ELISA | (1) |
Use at an assay dependent concentration.
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| IHC-Fr |
Use at an assay dependent concentration.
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| Functional Studies |
Use at an assay dependent concentration.
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| WB |
Use at an assay dependent concentration.
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| IHC-P |
Use at an assay dependent concentration.
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| Notes |
|---|
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ELISA
Use at an assay dependent concentration. |
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IHC-Fr
Use at an assay dependent concentration. |
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Functional Studies
Use at an assay dependent concentration. |
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WB
Use at an assay dependent concentration. |
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IHC-P
Use at an assay dependent concentration. |
Target
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Relevance
C5 is involved in the activation of the lytic pathway within the complement system, which is an important factor in innate immunity. -
Database links
- Entrez Gene: 727 Human
- Omim: 120900 Human
- SwissProt: P01031 Human
- SwissProt: Q14CJ0 Human
- SwissProt: Q27I61 Human
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Alternative names
- Anaphylatoxin C5a analog antibody
- C5 antibody
- C5a anaphylatoxin antibody
see all
Protocols
Datasheets and documents
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Datasheet download
References (5)
ab11878 has been referenced in 5 publications.
- Yuan K et al. Complement C3 overexpression activates JAK2/STAT3 pathway and correlates with gastric cancer progression. J Exp Clin Cancer Res 39:9 (2020). PubMed: 31928530
- Arbore G et al. Complement receptor CD46 co-stimulates optimal human CD8+ T cell effector function via fatty acid metabolism. Nat Commun 9:4186 (2018). PubMed: 30305631
- Xi W et al. High Level of Anaphylatoxin C5a Predicts Poor Clinical Outcome in Patients with Clear Cell Renal Cell Carcinoma. Sci Rep 6:29177 (2016). IHC ; Human . PubMed: 27381421
- Ecker SM et al. Aqueous cytokine and growth factor levels do not reliably reflect those levels found in the vitreous. Mol Vis 17:2856-63 (2011). WB ; Human . PubMed: 22128233
- Nozaki M et al. Drusen complement components C3a and C5a promote choroidal neovascularization. Proc Natl Acad Sci U S A 103:2328-33 (2006). IHC-Fr ; Mouse, Human . PubMed: 16452172
