Anti-C5a-R antibody [10/92] (ab117579)
![Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-C5a-R antibody [10/92] (ab117579)](https://www.abcam.com/ps/products/117/ab117579/Images/ab117579-129120-anti-c5a-r-antibody-10-92-immunohistochemistry.jpg "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-C5a-R antibody [10/92] (ab117579)")
Key features and details
- Rat monoclonal [10/92] to C5a-R
- Suitable for: IHC-P
- Reacts with: Mouse
- Isotype: IgG2a
Related conjugates and formulations
Overview
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Product name
Anti-C5a-R antibody [10/92]
See all C5a-R primary antibodies -
Description
Rat monoclonal [10/92] to C5a-R -
Host species
Rat -
Tested applications
Suitable for: IHC-Pmore details -
Species reactivity
Reacts with: Mouse -
Immunogen
Tissue, cells or virus corresponding to Mouse C5a-R. RBL-2H3 transfected cells
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Positive control
- Mouse Kidney tissue.
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
Storage buffer
pH: 7.40
Preservative: 0.09% Sodium azide
Constituent: 99% PBS -
Concentration information loading... -
Purity
Protein G purified -
Clonality
Monoclonal -
Clone number
10/92 -
Isotype
IgG2a -
Research areas
Associated products
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Alternative Versions
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Compatible Secondaries
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Conjugation kits
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Isotype control
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Recombinant Protein
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab117579 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| Application | Abreviews | Notes |
|---|---|---|
| IHC-P |
Use a concentration of 10 µg/ml.
|
| Notes |
|---|
|
IHC-P
Use a concentration of 10 µg/ml. |
Target
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Function
Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a. This receptor stimulates chemotaxis, granule enzyme release and superoxide anion production. -
Sequence similarities
Belongs to the G-protein coupled receptor 1 family. -
Post-translational
modificationsSulfation plays a critical role in the association of the receptor with C5a, but no significant role in the ability of the receptor to transduce a signal and mobilize calcium in response to a small peptide agonist. -
Cellular localization
Cell membrane. - Information by UniProt
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Database links
- Entrez Gene: 12273 Mouse
- SwissProt: P30993 Mouse
- SwissProt: Q3TZ86 Mouse
- Unigene: 247623 Mouse
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Alternative names
- ANAPHYLATOXIN RECEPTOR antibody
- C5a anaphylatoxin chemotactic receptor antibody
- C5a anaphylatoxin receptor antibody
see all
Images
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-C5a-R antibody [10/92] (ab117579)
Immunohistochemical analysis of C5a-R expression in Formalin-Fixed, Paraffin-Embedded Mouse Kidney tissue sing 10 µg/ml ab117579.
Datasheets and documents
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Datasheet download
References (4)
ab117579 has been referenced in 4 publications.
- Hu X et al. Respiratory Syncytial Virus Exacerbates Kidney Damages in IgA Nephropathy Mice via the C5a-C5aR1 Axis Orchestrating Th17 Cell Responses. Front Cell Infect Microbiol 9:151 (2019). PubMed: 31134161
- Song D et al. Complement C5a receptor knockout has diminished light-induced microglia/macrophage retinal migration. Mol Vis 23:210-218 (2017). IHC-Fr ; Mouse . PubMed: 28442885
- Hu X et al. Respiratory Syncytial Virus Exacerbates OVA-mediated asthma in mice through C5a-C5aR regulating CD4+T cells Immune Responses. Sci Rep 7:15207 (2017). IHC . PubMed: 29123203
- Li G et al. Neuroprotective effects of argatroban and C5a receptor antagonist (PMX53) following intracerebral haemorrhage. Clin Exp Immunol 175:285-95 (2014). PubMed: 24117111
