Overview

  • Product name

    Anti-C5b-9 antibody [aE11] (Biotin)
    See all C5b-9 primary antibodies
  • Description

    Mouse monoclonal [aE11] to C5b-9 (Biotin)
  • Host species

    Mouse
  • Conjugation

    Biotin
  • Specificity

    ab237699 binds both membrane-bound MAC (active) and fluid-phase SC5b-9 complexes (inactive).
  • Tested applications

    Suitable for: ELISAmore details
  • Species reactivity

    Reacts with: Horse, Human, Pig, Baboon
  • Immunogen

    Full length native protein (purified) corresponding to Human C5b-9.
    Database link: P01031

  • Epitope

    ab237699 binds to a neoepitope exposed on C9.

Properties

Applications

Our Abpromise guarantee covers the use of ab237699 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ELISA Use at an assay dependent concentration.

Target

  • Relevance

    Activation of the complement system plays a key role in normal inflammatory response to injury but may cause substantial injury when activated inappropriately. The complement system is activated either through the classical (antibody induced) or the alternative (microbial surface, polysacharride induced) pathway, both leading to the formation of the C5b9 complex. Fluid phase binding of the multifunctional glycoprotein S protein (vitronectin) to C5b9 leads to the formation of a cytolytically inactive complex, SC5b9, which is unable to attach to cells.
  • Cellular localization

    Secreted
  • Database links

  • Alternative names

    • C5 antibody
    • c5b 9 antibody
    • C6 antibody
    • C7 antibody
    • C8 antibody
    • C9 antibody
    • Complement component 5 antibody
    • Complement component 6 antibody
    • Complement component 7 antibody
    • Complement component 8 antibody
    • Complement component 9 antibody
    see all

References

ab237699 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab237699.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
For licensing inquiries, please contact partnerships@abcam.com

Sign up