Key features and details
- Mouse monoclonal [3G11] to C6
- Suitable for: WB, ELISA, IHC-Fr
- Reacts with: Rat
- Isotype: IgG1
Product nameAnti-C6 antibody [3G11]
See all C6 primary antibodies
DescriptionMouse monoclonal [3G11] to C6
Tested applicationsSuitable for: WB, ELISA, IHC-Frmore details
Species reactivityReacts with: Rat
C6 isolated from rat serum.
- Rat serum and urine.
Storage instructionsShipped at 4°C. Store at +4°C.
Storage bufferPreservative: 0.02% Sodium azide
Constituents: 99% PBS, 0.1% BSA
Concentration information loading...
PurityProtein G purified
Our Abpromise guarantee covers the use of ab155581 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|WB||1/50. Predicted molecular weight: 105 kDa.|
|ELISA||Use at an assay dependent concentration.|
FunctionConstituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells.
Involvement in diseaseDefects in C6 are the cause of complement component 6 deficiency (C6D) [MIM:612446]. A rare defect of the complement classical pathway associated with susceptibility to severe recurrent infections, predominantly by Neisseria gonorrhoeae or Neisseria meningitidis.
Sequence similaritiesBelongs to the complement C6/C7/C8/C9 family.
Contains 1 EGF-like domain.
Contains 2 Kazal-like domains.
Contains 1 LDL-receptor class A domain.
Contains 1 MACPF domain.
Contains 2 Sushi (CCP/SCR) domains.
Contains 3 TSP type-1 domains.
modificationsAll cysteine residues are assumed to be cross-linked to one another. Individual modules containing an even number of conserved cysteine residues are supposed to have disulfide linkages only within the same module.
- Information by UniProt
- AW111623 antibody
- C6 antibody
- CO6_HUMAN antibody
ab155581 has been referenced in 1 publication.
- Sato T et al. The terminal sequence of complement plays an essential role in antibody-mediated renal cell apoptosis. J Am Soc Nephrol 10:1242-52 (1999). PubMed: 10361862