Anti-C6 antibody (ab230776)

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Overview

  • Product name

    Anti-C6 antibody
    See all C6 primary antibodies

  • Description

    Goat polyclonal to C6

  • Host species

    Goat

  • Tested applications

    Suitable for: IHC-Pmore details

  • Species reactivity

    Reacts with: Human

  • Immunogen

    Full length native protein (purified) corresponding to Human C6 aa 1-934. (Highly purified).
    Database link: P13671

  • Positive control

    • IHC-P: Human placenta tissue.

Properties

  • Form

    Liquid

  • Storage instructions

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.

  • Storage buffer

    Preservative: 0.09% Sodium azide

  • Purity

    Whole antiserum

  • Clonality

    Polyclonal

  • Isotype

    IgG

  • Research areas

Applications

Our Abpromise guarantee covers the use of ab230776 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/100. Perform heat mediated antigen retrieval before commencing with IHC staining protocol.

Target

  • Function

    Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells.

  • Involvement in disease

    Defects in C6 are the cause of complement component 6 deficiency (C6D) [MIM:612446]. A rare defect of the complement classical pathway associated with susceptibility to severe recurrent infections, predominantly by Neisseria gonorrhoeae or Neisseria meningitidis.

  • Sequence similarities

    Belongs to the complement C6/C7/C8/C9 family.
    Contains 1 EGF-like domain.
    Contains 2 Kazal-like domains.
    Contains 1 LDL-receptor class A domain.
    Contains 1 MACPF domain.
    Contains 2 Sushi (CCP/SCR) domains.
    Contains 3 TSP type-1 domains.

  • Post-translational
    modifications

    All cysteine residues are assumed to be cross-linked to one another. Individual modules containing an even number of conserved cysteine residues are supposed to have disulfide linkages only within the same module.

  • Cellular localization

    Secreted.
  • Information by UniProt

  • Database links

    • Alternative names

      • AW111623 antibody
      • C6 antibody
      • CO6_HUMAN antibody
      • Complement component 6 antibody
      • Complement component C6 antibody
      see all

    Images

    • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-C6 antibody (ab230776)
      Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-C6 antibody (ab230776)

      Formalin-fixed, paraffin-embedded human placenta tissue stained for C6 using ab230776 at 1/100 dilution in immunohistochemical analysis.

    References

    ab230776 has not yet been referenced specifically in any publications.

    Publishing research using ab230776? Please let us know so that we can cite the reference in this datasheet.

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