Overview

  • Product name

    C6 Ceramide, biologically active ceramide analog
  • Description

    Non-physiological and biologically active ceramide analog.
  • Biological description

    Non-physiological and biologically active ceramide analog. Various pharmacological activities including activation of protein phosphatase 2A and MAPK, suppression of insulin-induced tyrosine phosphorylation and induction of cell cycle arrest at the G0/G1 transition. Active in vivo and in vitro.
  • Purity

    > 98%
  • CAS Number

    124753-97-5
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    N-(1,3-Dihydroxyoctadec-4-en-2-yl)hexanamide
  • Molecular weight

    397.70
  • Molecular formula

    C24H47NO3
  • PubChem identifier

    375405
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 100 mM and in ethanol to 50 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CCCCCCCCCCCCCC=CC(C(CO)NC(=O)CCCCC)O
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Kue CS  et al. C6-ceramide enhances Interleukin-12-mediated T helper type 1 cell responses through a cyclooxygenase-2-dependent pathway. Immunobiology 217:601-9 (2012). Read more (PubMed: 22112438) »
  • Zhu QY  et al. C6-ceramide synergistically potentiates the anti-tumor effects of histone deacetylase inhibitors via AKT dephosphorylation and a-tubulin hyperacetylation both in vitro and in vivo. Cell Death Dis 2:e117 (2011). Read more (PubMed: 21368888) »
  • Bansode RR  et al. Coupling in vitro and in vivo paradigm reveals a dose dependent inhibition of angiogenesis followed by initiation of autophagy by C6-ceramide. Int J Biol Sci 7:629-44 (2011). Read more (PubMed: 21647331) »

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab141743.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
For licensing inquiries, please contact partnerships@abcam.com

Sign up