Product nameAnti-C9 antibody [aE11]
See all C9 primary antibodies
DescriptionMouse monoclonal [aE11] to C9
Tested applicationsSuitable for: ELISA, IHC-P, IHC-Fr, Flow Cyt, Functional Studiesmore details
Unsuitable for: WB
Species reactivityReacts with: Horse, Human, Pig
Human purified MAC (membrane attack complex)
- Mucosa from patients with H. Pylori.
Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Storage bufferPreservative: 0.02% Sodium azide
Constituents: PBS, 0.1% BSA
Concentration information loading...
PurityProtein A purified
Purification notesab90801 was filtered through a 0.2 µm filter.
Our Abpromise guarantee covers the use of ab90801 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|IF||Use at an assay dependent concentration.|
|ELISA||Use at an assay dependent concentration.|
ab170191 - Mouse monoclonal IgG2a, is suitable for use as an isotype control with this antibody.
|Functional Studies||Use at an assay dependent concentration. aE11 inhibits platelet activation by antiphospholipid antibody serum.|
FunctionConstituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. C9 is the pore-forming subunit of the MAC.
Involvement in diseaseDefects in C9 are a cause of complement component 9 deficiency (C9D) [MIM:613825]. A rare defect of the complement classical pathway associated with susceptibility to severe recurrent infections, predominantly by Neisseria gonorrhoeae or Neisseria meningitidis.
Sequence similaritiesBelongs to the complement C6/C7/C8/C9 family.
Contains 1 EGF-like domain.
Contains 1 LDL-receptor class A domain.
Contains 1 MACPF domain.
Contains 1 TSP type-1 domain.
modificationsThrombin cleaves factor C9 to produce C9a and C9b.
Phosphorylation sites are present in the extracelllular medium.
Cellular localizationSecreted. Cell membrane. Secreted as soluble monomer. Oligomerizes at target membranes, forming a pre-pore. A conformation change then leads to the formation of a 100 Angstrom diameter pore.
- Information by UniProt
- ARMD15 antibody
- C9 antibody
- C9 deficiency antibody
This product has been referenced in:
- Meuwissen M et al. Colocalisation of intraplaque C reactive protein, complement, oxidised low density lipoprotein, and macrophages in stable and unstable angina and acute myocardial infarction. J Clin Pathol 59:196-201 (2006). IHC-Fr ; Human . Read more (PubMed: 16443738) »
- Berstad AE et al. Epithelium related deposition of activated complement in Helicobacter pylori associated gastritis. Gut 40:196-203 (1997). IHC-P, IF ; Human . Read more (PubMed: 9071931) »