Overview

  • Product name

  • Description

    Rabbit polyclonal to CABLES1
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WBmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Mouse, Rat, Rabbit, Horse, Chicken, Guinea pig, Cow, Cat, Dog, Zebrafish
  • Immunogen

    Synthetic peptide corresponding to a region within C terminal amino acids 214-263 (PSYMTTVIDY VKPSDLKKDM NETFKEKFPH IKLTLSKIRS LKREMRKLAQ) of Human CABLES1 (NP_612384).

  • Positive control

    • RPMI-8226 cell lysate.

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
  • Storage buffer

    Preservative: 0.09% Sodium azide
    Constituents: 2% Sucrose, PBS
  • Concentration information loading...
  • Purity

    Immunogen affinity purified
  • Clonality

    Polyclonal
  • Isotype

    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab130967 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 42 kDa.

Target

  • Function

    Cyclin-dependent kinase binding protein. Enhances cyclin-dependent kinase tyrosine phosphorylation by nonreceptor tyrosine kinases, such as that of CDK5 by activated ABL1, which leads to increased CDK5 activity and is critical for neuronal development, and that of CDK2 by WEE1, which leads to decreased CDK2 activity and growth inhibition. Positively affects neuronal outgrowth. Plays a role as a regulator for p53/p73-induced cell death.
  • Tissue specificity

    Expressed in breast, pancreas, colon, head and neck (at protein level). Strongly decreased in more than half of cases of atypical endometrial hyperplasia and in more than 90% of endometrial cancers.
  • Sequence similarities

    Belongs to the cyclin family.
  • Developmental stage

    Expression in the endometrial epithelium fluctuates during the menstrual cycle, being greater during the secretory phase when compared with the proliferative phase.
  • Post-translational
    modifications

    Phosphorylated on Ser-313 by CCNE1/CDK3. Phosphorylated on serine/threonine residues by CDK5 and on tyrosine residues by ABL1. Also phosphorylated in vitro by CCNA1/CDK2, CCNE1/CDK2, CCNA1/CDK3 and CCNE1/CDK3.
  • Cellular localization

    Nucleus. Cytoplasm. Located in the cell body and proximal region of the developing axonal shaft of immature neurons. Located in axonal growth cone, but not in the distal part of the axon shaft or in dendritic growth cone of mature neurons.
  • Information by UniProt
  • Database links

  • Alternative names

    • CABL1_HUMAN antibody
    • CABLES antibody
    • Cables1 antibody
    • Cdk5 and Abl enzyme substrate 1 antibody
    • CDK5 and ABL1 enzyme substrate 1 antibody
    • FLJ35924 antibody
    • HsT2563 antibody
    • IK3 1 antibody
    • Ik3-1 antibody
    • Interactor with CDK3 1 antibody
    see all

Images

  • Anti-CABLES1 antibody (ab130967) at 1 µg/ml + RPMI-8226 cell lysate at 10 µg

    Secondary
    Goat anti-Rabbit IgG HRP

    Predicted band size: 42 kDa



    Gel concentration: 12%

References

ab130967 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab130967.
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