Cabotegravir, HIV integrase inhibitor (ab231362)

Overview

  • Product name

    Cabotegravir, HIV integrase inhibitor
  • Description

    Long-acting HIV integrase inhibitor
  • Alternative names

    • GSK1265744
    • GSK744
  • Biological description

    Long-acting HIV integrase inhibitor against a broad range of HIV subtypes. Inhibits  HIV-1 integrase catalyzed strand transfer reaction (IC50 = 3.0 nM). Inhibits HIV replication (EC50 values of 0.22 nM and 0.34-1.3 nM against HIV-1 Ba-L and NL432 respectively).

  • CAS Number

    1051375-10-0
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    (3S,11aR)- N-[(2,4-Difluorophenyl)methyl]-2,3,5,7,11,11a-hexahydro-6-hydroxy-3-methyl-5,7-dioxo-oxazolo[3,2-a]pyrido[1,2-d]pyrazine-8-carboxamide
  • Molecular weight

    405.35
  • Molecular formula

    C19H17F2N3O5
  • PubChem identifier

    54713659
  • Storage instructions

    Shipped at 4°C. Store at -20°C.
  • SMILES

    C[C@H]1CO[C@H]2N1C(=O)C3=C(C(=O)C(=CN3C2)C(=O)NCC4=C(C=C(C=C4)F)F)O
  • Source

    Synthetic

References

This product has been referenced in:

  • Yoshinaga T  et al. Antiviral characteristics of GSK1265744, an HIV integrase inhibitor dosed orally or by long-acting injection. Antimicrob Agents Chemother 59:397-406 (2015). Read more (PubMed: 25367908) »
  • Andrews CD  et al. A long-acting integrase inhibitor protects female macaques from repeated high-dose intravaginal SHIV challenge. Sci Transl Med 7:270ra4 (2015). Read more (PubMed: 25589630) »

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