Voltage activated calcium channels can be distinguished based on their voltage dependence, deactivation, and single channel conductance. Low voltage activated calcium channels are referred to as 'T' type because their currents are both transient, owing to fast inactivation, and tiny, owing to small conductance. T type channels are thought to be involved in pacemaker activity, low threshold calcium spikes, neuronal oscillations and resonance, and rebound burst firing.
Dziegielewska B et al. T-type Ca2+ channel inhibition induces p53-dependent cell growth arrest and apoptosis through activation of p38-MAPK in colon cancer cells. Mol Cancer Res12:348-58 (2014).
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