Overview

  • Product name

  • Description

    Rabbit polyclonal to CACNA1H
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WBmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Mouse, Rat
  • Immunogen

    Synthetic peptide corresponding to internal sequence amino acids of Human CACNA1H.

  • Positive control

    • HeLa cell lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab135974 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/1000. Predicted molecular weight: 259 kDa.

Target

  • Function

    Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1H gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite negative potentials, and a voltage-dependent inactivation. T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle. They may also be involved in the modulation of firing patterns of neurons which is important for information processing as well as in cell growth processes.
  • Tissue specificity

    Expressed in kidney, liver, heart, brain. Isoform 2 seems to be testis-specific.
  • Involvement in disease

    Defects in CACNA1H are a cause of susceptibility to idiopathic generalized epilepsy type 6 (IGE6) [MIM:611942]. IGE is characterized by recurring generalized seizures in the absence of detectable brain lesions and/or metabolic abnormalities. Generalized seizures arise diffusely and simultaneously from both hemispheres of the brain. IGE6 is a polygenic and multifactorial disease.
  • Sequence similarities

    Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. CACNA1H subfamily.
  • Domain

    Each of the four internal repeats contains five hydrophobic transmembrane segments (S1, S2, S3, S5, S6) and one positively charged transmembrane segment (S4). S4 segments probably represent the voltage-sensor and are characterized by a series of positively charged amino acids at every third position.
  • Post-translational
    modifications

    In response to raising of intracellular calcium, the T-type channels are activated by CaM-kinase II.
  • Cellular localization

    Membrane.
  • Information by UniProt
  • Database links

  • Alternative names

    • Alpha1 3.2 antibody
    • Alpha13.2 antibody
    • CAC1H_HUMAN antibody
    • CACNA 1H antibody
    • CACNA1 H antibody
    • CACNA1 HB antibody
    • Cacna1h antibody
    • CACNA1HB antibody
    • Calcium channel alpha13.2 subunit antibody
    • Calcium channel voltage dependent T type alpha 1H subunit antibody
    • Calcium channel, voltage-dependent, T type, alpha 1Hb subunit antibody
    • Cav 3.2 antibody
    • Cav T.2 antibody
    • Cav3.2 antibody
    • CavT.2 antibody
    • EIG 6 antibody
    • EIG6 antibody
    • Low voltage activated calcium channel alpha 13.2 subunit antibody
    • Low voltage activated calcium channel alpha1 3.2 subunit antibody
    • Low-voltage-activated calcium channel alpha1 3.2 subunit antibody
    • MNCb 1209 antibody
    • T type Cav3.2 antibody
    • Voltage dependent t type calcium channel alpha 1H subunit antibody
    • Voltage gated calcium channel alpha subunit Cav 3.2 antibody
    • Voltage gated calcium channel alpha subunit Cav T.2 antibody
    • Voltage gated calcium channel alpha subunit Cav3.2 antibody
    • Voltage gated calcium channel alpha subunit CavT.2 antibody
    • Voltage-dependent T-type calcium channel subunit alpha-1H antibody
    • Voltage-gated calcium channel subunit alpha Cav3.2 antibody
    see all

Images

  • Anti-CACNA1H antibody (ab135974) at 1/500 dilution + HeLa cell lysate at 30 µg

    Predicted band size: 259 kDa

References

ab135974 has not yet been referenced specifically in any publications.

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