Key features and details
- Rabbit polyclonal to CACNA2D2
- Suitable for: ICC/IF
- Reacts with: Human
- Isotype: IgG
Product nameAnti-CACNA2D2 antibody
See all CACNA2D2 primary antibodies
DescriptionRabbit polyclonal to CACNA2D2
Tested applicationsSuitable for: ICC/IFmore details
Species reactivityReacts with: Human
Predicted to work with: Mouse, Rat
- ICC/IF: SH-SY5Y cells.
Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
Storage bufferpH: 7.20
Preservative: 0.02% Sodium azide
Constituents: 40% Glycerol (glycerin, glycerine), PBS
Concentration information loading...
PurityImmunogen affinity purified
Our Abpromise guarantee covers the use of ab221865 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|ICC/IF||Use a concentration of 0.25 - 2 µg/ml.
Fixation/Permeabilization: PFA/Triton X-100.
FunctionThe alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Acts as a regulatory subunit for P/Q-type calcium channel (CACNA1A), N-type (CACNA1B), L-type (CACNA1C OR CACNA1D) and possibly T-type (CACNA1G). Overexpression induces apoptosis.
Tissue specificityPredominantly present in cerebellar cortex. Present in various lung tumor cell lines, while it is absent in normal lung (at protein level). Highly expressed in heart, lung, testis, pancreas and skeletal muscle. Also expressed in kidney, liver, placenta and brain.
Sequence similaritiesBelongs to the calcium channel subunit alpha-2/delta family.
Contains 1 cache domain.
Contains 1 VWFA domain.
DomainThe MIDAS-like motif in the VWFA domain binds divalent metal cations and is required to promote trafficking of the alpha-1 (CACNA1) subunit to the plasma membrane by an integrin-like switch.
modificationsMay be proteolytically processed into subunits alpha-2-2 and delta-2 that are disulfide-linked. It is however unclear whether such cleavage really takes place in vivo and has a functional role.
Cellular localizationMembrane. Colocalizes with CACNA1A in lipid raft fractions.
- Information by UniProt
- Alpha 2 delta calcium channel subunit antibody
- CA2D2_HUMAN antibody
- CACNA2D antibody
ab221865 has not yet been referenced specifically in any publications.