Overview

  • Product name

  • Description

    Goat polyclonal to CACNB4
  • Host species

    Goat
  • Specificity

    This antibody is expected to recognise all three reported isoforms.
  • Tested applications

    Suitable for: WB, ELISAmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Mouse, Cow, Pig, Chinese hamster
  • Immunogen

    Synthetic peptide:

    C-DYPDSYQDTYKPH

    , corresponding to near C terminal amino acids 491-503 of Human CACNB4

  • Positive control

    • Human Bone Marrow lysate

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • Storage buffer

    Preservative: 0.02% Sodium Azide
    Constituents: 0.5% BSA, Tris buffered saline, pH 7.3
  • Concentration information loading...
  • Purity

    Immunogen affinity purified
  • Clonality

    Polyclonal
  • Isotype

    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab58601 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB
ELISA
  • Application notes
    Peptide ELISA: antibody detection limit dilution 1:4,000.
    WB: Use at a concentration of 0.2 - 0.6 µg/ml. Detects a band of approximately 58 kDa (predicted molecular weight: 58 kDa).


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • Function

      The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting.
    • Tissue specificity

      Expressed predominantly in the cerebellum and kidney.
    • Involvement in disease

      Genetic variations in CACNB4 are the cause of susceptibility to idiopathic generalized epilepsy type 9 (IGE9) [MIM:607682]. IGE9 is characterized by recurring generalized seizures in the absence of detectable brain lesions and/or metabolic abnormalities. Generalized seizures arise diffusely and simultaneously from both hemispheres of the brain.
      Genetic variations in CACNB4 are the cause of susceptibility to juvenile myoclonic epilepsy type 6 (EJM6) [MIM:607682]. EJM6 is a subtype of idiopathic generalized epilepsy. Patients have afebrile seizures only, with onset in adolescence (rather than in childhood) and myoclonic jerks which usually occur after awakening and are triggered by sleep deprivation and fatigue.
    • Sequence similarities

      Belongs to the calcium channel beta subunit family.
      Contains 1 SH3 domain.
    • Information by UniProt
    • Database links

    • Alternative names

      • CAB4 antibody
      • CACB4_HUMAN antibody
      • Cacnb4 antibody
      • CACNLB4 antibody
      • Calcium channel voltage dependent beta 4 subunit antibody
      • Calcium channel voltage dependent subunit beta 4 antibody
      • Calcium channel voltage-dependent subunit beta 4 antibody
      • Dihydropyridine sensitive L type calcium channel beta 4 subunit antibody
      • EA5 antibody
      • EIG9 antibody
      • EJM antibody
      • EJM4 antibody
      • EJM6 antibody
      • Voltage-dependent L-type calcium channel subunit beta-4 antibody
      see all

    Images

    • Anti-CACNB4 antibody (ab58601) at 0.2 µg/ml + Human Bone Marrow lysate at 35 µg

      Predicted band size: 58 kDa
      Observed band size: 58 kDa



      Detected by chemiluminescence.

    References

    ab58601 has not yet been referenced specifically in any publications.

    Customer reviews and Q&As

    There are currently no Customer reviews or Questions for ab58601.
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