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    cadherin-10-antibody-epr5115-ab134137.pdf

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Neuroscience Cell Adhesion Proteins Membrane Proteins
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RecombinantRabMAb

Recombinant Anti-cadherin 10 antibody [EPR5115] (ab134137)

  • Datasheet
  • SDS
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Western blot - Anti-cadherin 10 antibody [EPR5115] (ab134137)
  • Flow Cytometry - Anti-cadherin 10 antibody [EPR5115] (ab134137)
  • Anti-cadherin 10 antibody [EPR5115] (ab134137)

Key features and details

  • Produced recombinantly (animal-free) for high batch-to-batch consistency and long term security of supply
  • Rabbit monoclonal [EPR5115] to cadherin 10
  • Suitable for: WB, Flow Cyt
  • Reacts with: Human

You may also be interested in

Secondary
Product image
Goat Anti-Rabbit IgG H&L (HRP) (ab205718)

View more associated products

Overview

  • Product name

    Anti-cadherin 10 antibody [EPR5115]
    See all cadherin 10 primary antibodies
  • Description

    Rabbit monoclonal [EPR5115] to cadherin 10
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WB, Flow Cytmore details
    Unsuitable for: ICC/IF,IHC-P or IP
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Mouse, Rat
  • Immunogen

    Synthetic peptide within Human cadherin 10 aa 750-850. The exact sequence is proprietary.
    (Peptide available as ab185240)

  • Positive control

    • Human fetal brain, fetal lung and U-87 MG; permeabilized U-87 MG cells.
  • General notes

     

     

    This product is a recombinant monoclonal antibody, which offers several advantages including:

    • - High batch-to-batch consistency and reproducibility
    • - Improved sensitivity and specificity
    • - Long-term security of supply
    • - Animal-free production
    For more information see here.

    Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Store at -20ºC.
  • Storage buffer

    pH: 7.2
    Preservative: 0.05% Sodium azide
    Constituents: 0.1% BSA, 40% Glycerol (glycerin, glycerine), 9.85% Tris glycine, 50% Tissue culture supernatant
  • Concentration information loading...
  • Purity

    Tissue culture supernatant
  • Clonality

    Monoclonal
  • Clone number

    EPR5115
  • Isotype

    IgG
  • Research areas

    • Neuroscience
    • Cell Adhesion Proteins
    • Membrane Proteins
    • Signal Transduction
    • Cytoskeleton / ECM
    • Cell Adhesion
    • Cadherins

Associated products

  • Alternative Versions

    • Anti-cadherin 10 antibody [EPR5115] - BSA and Azide free (ab248697)
  • Immunizing Peptide (Blocking)

    • cadherin 10 peptide (ab185240)
  • Isotype control

    • Rabbit IgG, monoclonal [EPR25A] - Isotype Control (ab172730)

Applications

The Abpromise guarantee

Our Abpromise guarantee covers the use of ab134137 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB
1/1000 - 1/10000. Predicted molecular weight: 88 kDa.Can be blocked with cadherin 10 peptide (ab185240).
Flow Cyt
1/10 - 1/100.

ab172730 - Rabbit monoclonal IgG, is suitable for use as an isotype control with this antibody.

 

Notes
WB
1/1000 - 1/10000. Predicted molecular weight: 88 kDa.Can be blocked with cadherin 10 peptide (ab185240).
Flow Cyt
1/10 - 1/100.

ab172730 - Rabbit monoclonal IgG, is suitable for use as an isotype control with this antibody.

 

  • Application notes
    Is unsuitable for ICC/IF,IHC-P or IP.
  • Target

    • Function

      Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.
    • Tissue specificity

      Predominantly expressed in brain. Also found in adult and fetal kidney. Very low levels detected in prostate and fetal lung.
    • Sequence similarities

      Contains 5 cadherin domains.
    • Domain

      Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.
    • Cellular localization

      Cell membrane.
    • Target information above from: UniProt accession Q9Y6N8 The UniProt Consortium
      The Universal Protein Resource (UniProt) in 2010
      Nucleic Acids Res. 38:D142-D148 (2010) .

      Information by UniProt
    • Database links

      • Entrez Gene: 1008 Human
      • Entrez Gene: 320873 Mouse
      • Entrez Gene: 29181 Rat
      • Omim: 604555 Human
      • SwissProt: Q9Y6N8 Human
      • SwissProt: P70408 Mouse
      • Unigene: 92489 Human
      • Unigene: 117794 Mouse
      • Unigene: 446240 Mouse
      • Unigene: 83592 Rat
      see all
    • Alternative names

      • CAD10_HUMAN antibody
      • Cadherin 10 (T2 cadherin) antibody
      • Cadherin 10 type 2 (T2 cadherin) antibody
      • Cadherin 10 type 2 antibody
      • Cadherin-10 antibody
      • Cadherin10 antibody
      • CDH10 antibody
      • T2 cadherin antibody
      • T2-cadherin antibody
      see all

    Images

    • Western blot - Anti-cadherin 10 antibody [EPR5115] (ab134137)
      Western blot - Anti-cadherin 10 antibody [EPR5115] (ab134137)
      All lanes : Anti-cadherin 10 antibody [EPR5115] (ab134137) at 1/1000 dilution

      Lane 1 : Human fetal brain lysate
      Lane 2 : U-87 MG lysate
      Lane 3 : Human fetal lung lysate

      Lysates/proteins at 10 µg per lane.

      Secondary
      All lanes : Goat Anti-rabbit HRP at 1/2000 dilution

      Predicted band size: 88 kDa

    • Flow Cytometry - Anti-cadherin 10 antibody [EPR5115] (ab134137)
      Flow Cytometry - Anti-cadherin 10 antibody [EPR5115] (ab134137)
      Flow cytometric analysis of permeabilised U-87 MG cells labelling cadherin 10 with ab134137 at 1/10 dilution (red) or rabbit IgG negative (green).
    • Anti-cadherin 10 antibody [EPR5115] (ab134137)
      Anti-cadherin 10 antibody [EPR5115] (ab134137)

    Protocols

    • Western blot protocols
    • Flow cytometry protocols

    Click here to view the general protocols

    Datasheets and documents

    • SDS download

    • Datasheet download

      Download

    References (1)

    Publishing research using ab134137? Please let us know so that we can cite the reference in this datasheet.

    ab134137 has been referenced in 1 publication.

    • Witte H  et al. A Sam68-dependent alternative splicing program shapes postsynaptic protein complexes. Eur J Neurosci 49:1436-1453 (2019). PubMed: 30589479

    Customer reviews and Q&As

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