Anti-Cadherin like 23 antibody (ab131135)
Key features and details
- Rabbit polyclonal to Cadherin like 23
- Suitable for: IHC-P, ICC/IF
- Reacts with: Human
- Isotype: IgG
Overview
-
Product name
Anti-Cadherin like 23 antibody -
Description
Rabbit polyclonal to Cadherin like 23 -
Host species
Rabbit -
Tested applications
Suitable for: IHC-P, ICC/IFmore details -
Species reactivity
Reacts with: Human
Predicted to work with: Mouse, Rat -
Immunogen
Synthetic peptide from the N terminus of Human Cadherin like 23
-
Positive control
- Human spleen tissue; HeLa cells.
-
General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
-
Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C long term. -
Storage buffer
pH: 7.40
Preservative: 0.02% Sodium azide
Constituents: 0.88% Sodium chloride, 50% Glycerol, 49% PBS
PBS is without Mg2+ and Ca2+ -
Concentration information loading...
-
Purity
Immunogen affinity purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
-
Compatible Secondaries
-
Isotype control
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab131135 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
---|---|---|
IHC-P |
1/100.
|
|
ICC/IF |
1/100 - 1/500.
|
Notes |
---|
IHC-P
1/100. |
ICC/IF
1/100 - 1/500. |
Target
-
Relevance
Cadherin like 23 (or Cadherin 23) is, like other members of the cadherin family, a calcium-dependent cell adhesion glycoprotein that preferentially interacts with itself in connecting cells. It is a single pass type I membrane protein that contains 27 cadherin domains. Cadherin like 23 is expressed in the neurosensory epithelium, where it is thought to be involved in stereocilia organisation and hair bundle formation. Defects in the gene encoding Cadherin like 23 are a cause of Usher syndrome, which is characterised by profound congenital sensorineural deafness and eventual blindness. Mutations in this gene are also a cause of non-syndromic sensorineural deafness autosomal recessive type 12 (DFNB12). Cadherin like 23 has also been associated with age-related hearing loss. -
Cellular localization
Cell membrane; Single-pass type I membrane protein -
Database links
- Entrez Gene: 64072 Human
- Entrez Gene: 22295 Mouse
- Entrez Gene: 114102 Rat
- Omim: 605516 Human
- SwissProt: Q9H251 Human
- SwissProt: Q99PF4 Mouse
- SwissProt: P58365 Rat
- Unigene: 656032 Human
see all -
Alternative names
- Age related hearing loss 1 antibody
- Ahl 1 antibody
- Ahl antibody
see all
Images
-
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Cadherin like 23 antibody (ab131135)Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human spleen tissue labelling Cadherin like 23 with ab131135 at 1/100 dilution.
-
Immunofluorescence analysis of HeLa cells labelling Cadherin like 23 with ab131135 at 1/100 dilution. The picture on the right is treated with immunising peptide.
Protocols
Datasheets and documents
-
SDS download
-
Datasheet download
References (0)
ab131135 has not yet been referenced specifically in any publications.