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    cadherin-like-23-antibody-ab131135.pdf

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Signal Transduction Cytoskeleton / ECM Cell Adhesion Cadherins
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Anti-Cadherin like 23 antibody (ab131135)

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  • SDS
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Cadherin like 23 antibody (ab131135)
  • Immunocytochemistry/ Immunofluorescence - Anti-Cadherin like 23 antibody (ab131135)

Key features and details

  • Rabbit polyclonal to Cadherin like 23
  • Suitable for: IHC-P, ICC/IF
  • Reacts with: Human
  • Isotype: IgG

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Goat Anti-Rabbit IgG H&L (HRP) (ab205718)

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Overview

  • Product name

    Anti-Cadherin like 23 antibody
  • Description

    Rabbit polyclonal to Cadherin like 23
  • Host species

    Rabbit
  • Tested applications

    Suitable for: IHC-P, ICC/IFmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Mouse, Rat
  • Immunogen

    Synthetic peptide from the N terminus of Human Cadherin like 23

  • Positive control

    • Human spleen tissue; HeLa cells.
  • General notes

    The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.

    If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C long term.
  • Storage buffer

    pH: 7.40
    Preservative: 0.02% Sodium azide
    Constituents: 0.88% Sodium chloride, 50% Glycerol, 49% PBS

    PBS is without Mg2+ and Ca2+
  • Concentration information loading...
  • Purity

    Immunogen affinity purified
  • Clonality

    Polyclonal
  • Isotype

    IgG
  • Research areas

    • Signal Transduction
    • Cytoskeleton / ECM
    • Cell Adhesion
    • Cadherins
    • Neuroscience
    • Sensory System
    • Visual system
    • Neuroscience
    • Sensory System
    • Auditory system

Associated products

  • Compatible Secondaries

    • Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (ab150077)
    • Goat Anti-Rabbit IgG H&L (HRP) (ab205718)
  • Isotype control

    • Rabbit IgG, polyclonal - Isotype Control (ChIP Grade) (ab171870)

Applications

The Abpromise guarantee

Our Abpromise guarantee covers the use of ab131135 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P
1/100.
ICC/IF
1/100 - 1/500.
Notes
IHC-P
1/100.
ICC/IF
1/100 - 1/500.

Target

  • Relevance

    Cadherin like 23 (or Cadherin 23) is, like other members of the cadherin family, a calcium-dependent cell adhesion glycoprotein that preferentially interacts with itself in connecting cells. It is a single pass type I membrane protein that contains 27 cadherin domains. Cadherin like 23 is expressed in the neurosensory epithelium, where it is thought to be involved in stereocilia organisation and hair bundle formation. Defects in the gene encoding Cadherin like 23 are a cause of Usher syndrome, which is characterised by profound congenital sensorineural deafness and eventual blindness. Mutations in this gene are also a cause of non-syndromic sensorineural deafness autosomal recessive type 12 (DFNB12). Cadherin like 23 has also been associated with age-related hearing loss.
  • Cellular localization

    Cell membrane; Single-pass type I membrane protein
  • Database links

    • Entrez Gene: 64072 Human
    • Entrez Gene: 22295 Mouse
    • Entrez Gene: 114102 Rat
    • Omim: 605516 Human
    • SwissProt: Q9H251 Human
    • SwissProt: Q99PF4 Mouse
    • SwissProt: P58365 Rat
    • Unigene: 656032 Human
    • Unigene: 208796 Rat
    see all
  • Alternative names

    • Age related hearing loss 1 antibody
    • Ahl 1 antibody
    • Ahl antibody
    • Ahl1 antibody
    • Bob antibody
    • Bobby antibody
    • Bus antibody
    • Bustling antibody
    • Cadherin 23 antibody
    • Cadherin23 antibody
    • CDH 23 antibody
    • Mdfw antibody
    • Modifier of deaf waddler antibody
    • nmf112 antibody
    • nmf181 antibody
    • nmf252 antibody
    • Otocadherin antibody
    • USH 1D antibody
    • USH1 D antibody
    • USH1D antibody
    • Waltzer antibody
    see all

Images

  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Cadherin like 23 antibody (ab131135)
    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Cadherin like 23 antibody (ab131135)
    Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human spleen tissue labelling Cadherin like 23 with ab131135 at 1/100 dilution.
  • Immunocytochemistry/ Immunofluorescence - Anti-Cadherin like 23 antibody (ab131135)
    Immunocytochemistry/ Immunofluorescence - Anti-Cadherin like 23 antibody (ab131135)
    Immunofluorescence analysis of HeLa cells labelling Cadherin like 23 with ab131135 at 1/100 dilution. The picture on the right is treated with immunising peptide.

Protocols

  • Immunohistochemistry protocols
  • Immunocytochemistry & immunofluorescence protocols

Click here to view the general protocols

Datasheets and documents

  • SDS download

  • Datasheet download

    Download

References (0)

Publishing research using ab131135? Please let us know so that we can cite the reference in this datasheet.

ab131135 has not yet been referenced specifically in any publications.

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