Overview

  • Product name

    Calcineurin (PP2B) Substrate
  • Description

    PKA peptide. Calcineurin/PP2B substrate.
  • Biological description

    PKA regulatory subunit type II peptide of cAMP-dependent protein kinase. Sensitive assay for calcineurin/PP2B activity.
  • Purity

    > 96%
  • CAS Number

    113873-67-9
  • Chemical structure

    Chemical Structure

Properties

  • Molecular weight

    2112.40
  • Molecular formula

    C92H150N28O29
  • Sequence

    DLDVPIPGRFDRRVSVAAE (Modifications: Ser-15 = Phosphorolation)
  • PubChem identifier

    16198110
  • Storage instructions

    Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in water
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one week. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Dougherty MK  et al. KSR2 is a calcineurin substrate that promotes ERK cascade activation in response to calcium signals. Mol Cell 34:652-62 (2009). Read more (PubMed: 19560418) »
  • Roy J  et al. A conserved docking site modulates substrate affinity for calcineurin, signaling output, and in vivo function. Mol Cell 25:889-901 (2007). Read more (PubMed: 17386265) »
  • Enz A  et al. Nonradioactive assay for protein phosphatase 2B (calcineurin) activity using a partial sequence of the subunit of cAMP-dependent protein kinase as substrate. Anal Biochem 216:147-53 (1994). Read more (PubMed: 8135344) »

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