Key features and details
- Potent, specific L-type Ca2+ channel blocker
- CAS Number: 178805-91-9
- Purity: > 98%
- Soluble in water
- Form / State: Solid
- Source: Dendroaspis polylepis polylepis
Product nameCalciseptine (Recombinant), L-type Ca2+ channel blocker
DescriptionPotent, specific L-type Ca2+ channel blocker
Biological descriptionPotent, specific L-type Ca2+ channel blocker (IC50 = 15 nM). Inactive on other voltage-dependent Ca2+ channels. Smooth muscle relaxant and cardiacontraction inhibitor. Neurotoxic. Active in vivo and in vitro.
SequenceMRICYIHKASLPRATKTCVENTCYKMFIRTQREYISERGCGCPTAMWPYQTECCKGDRCNK (Modifications: Disulfide bonds: 4-23, 18-40, 42-53, 54-59)
Storage instructionsStore at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
Solubility overviewSoluble in water
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one week. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Dendroaspis polylepis polylepis
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab141856 has not yet been referenced specifically in any publications.