Overview

  • Product name

    Anti-Calcitonin antibody [EPR68(2)]
    See all Calcitonin primary antibodies
  • Description

    Rabbit monoclonal [EPR68(2)] to Calcitonin
  • Host species

    Rabbit
  • Tested applications

    Suitable for: IHC-Pmore details
    Unsuitable for: Flow Cyt,ICC/IF,IP or WB
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Mouse, Rat
  • Immunogen

    A synthetic peptide corresponding to residues in Human Calcitonin (P01258).

  • Positive control

    • Human medullary carcinoma of thyroid gland.
  • General notes

     

     

    Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMab® patents.

    This product is a recombinant rabbit monoclonal antibody.

Properties

Applications

Our Abpromise guarantee covers the use of ab133235 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/100 - 1/250. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
  • Application notes
    Is unsuitable for Flow Cyt,ICC/IF,IP or WB.
  • Target

    • Relevance

      Calcitonin is a 32 amino acid peptide hormone synthesized by the parafollicular cells of the thyroid. It causes a rapid, but short lived, reduction in serum calcium and phosphate by promoting the incorporation of those ions in the bones. This effect is opposite to that of parathyroid hormone. Staining for calcitonin may be used for the identification of a spectrum of C cell proliferative abnormalities ranging from C cell hyperplasia to invasive tumors. Staining for calcitonin in medullary carcinoma of the thyroid produces a fine granular pattern in the cytoplasm. Amyloid deposits within the tumor may also exhibit varying degrees of calcitonin activity.
    • Cellular localization

      Cytoplasmic and Secreted
    • Database links

    • Alternative names

      • Alpha CGRP antibody
      • alpha type CGRP antibody
      • CALC 1 antibody
      • CALC A antibody
      • CALC1 antibody
      • calcitonin 1 antibody
      • calcitonin gene related peptide 1 antibody
      • calcitonin gene related peptide I antibody
      • calcitonin related polypeptide alpha antibody
      • CGRP 1 antibody
      • CGRP antibody
      • CGRP I antibody
      • CGRP1 antibody
      • CT antibody
      • katacalcin antibody
      • KC antibody
      see all

    Images

    • Immunohistochemical staining of Calcitonin in paraffin embedded Human medullary carcinoma of thyroid gland, using ab133235 at a 1/100 dilution.

      Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

    • Immunohistochemical analysis of paraffin embedded Human Papillary carcinoma of thyroid gland tissue using ab133235 showing -ve staining.

      Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

    • Immunohistochemical analysis of paraffin embedded Human Prostatic carcinoma tissue using ab133235 showing -ve staining.

      Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

    • Immunohistochemical analysis of paraffin embedded normal Human tonsil tissue using ab133235 showing -ve staining.

      Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

    • Immunohistochemical analysis of paraffin embedded Human Breast carcinoma tissue using ab133235 showing -ve staining.

      Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

    • Immunohistochemical analysis of paraffin embedded Human Glioma tissue using ab133235 showing -ve staining.

      Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

    References

    ab133235 has not yet been referenced specifically in any publications.

    Customer reviews and Q&As

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