Overview

  • Product name

    Anti-Calcium channel L type DHPR alpha 2 subunit/CACNA2D1 antibody
    See all Calcium channel L type DHPR alpha 2 subunit/CACNA2D1 primary antibodies
  • Description

    Rabbit polyclonal to Calcium channel L type DHPR alpha 2 subunit/CACNA2D1
  • Host species

    Rabbit
  • Tested applications

    Suitable for: IHC-P, ICC/IFmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Mouse, Rat
  • Immunogen

    Recombinant fragment corresponding to Human Calcium channel L type DHPR alpha 2 subunit/CACNA2D1 aa 528-668.
    Database link: P54289

  • Positive control

    • IHC-P: Human skeletal muscle tissue. ICC/IF: HeLa.
  • General notes

     This product was previously labelled as Calcium channel L type DHPR alpha 2 subunit

     

Properties

Applications

Our Abpromise guarantee covers the use of ab238110 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/20 - 1/200.
ICC/IF 1/200.

Target

  • Function

    The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Plays an important role in excitation-contraction coupling.
  • Tissue specificity

    Isoform 1 is expressed in skeletal muscle. Isoform 2 is expressed in the central nervous system. Isoform 2, isoform 4 and isoform 5 are expressed in neuroblastoma cells. Isoform 3, isoform 4 and isoform 5 are expressed in the aorta.
  • Sequence similarities

    Belongs to the calcium channel subunit alpha-2/delta family.
    Contains 1 cache domain.
    Contains 1 VWFA domain.
  • Domain

    The MIDAS-like motif in the VWFA domain binds divalent metal cations and is required to promote trafficking of the alpha-1 (CACNA1) subunit to the plasma membrane by an integrin-like switch.
  • Post-translational
    modifications

    Proteolytically processed into subunits alpha-2-1 and delta-1 that are disulfide-linked.
  • Cellular localization

    Membrane.
  • Information by UniProt
  • Database links

  • Alternative names

    • CA2D1_HUMAN antibody
    • CACN A2 antibody
    • CACNA2 antibody
    • Cacna2d1 antibody
    • CACNL2A antibody
    • Calcium channel L type alpha 2 polypeptide antibody
    • Calcium channel voltage dependent alpha 2/delta subunit 1 antibody
    • CCHL2A antibody
    • Dihydropyridine receptor alpha 2 subunit antibody
    • Dihydropyridine sensitive L type calcium channel alpha 2/delta subunit antibody
    • Dihydropyridine sensitive L type calcium channel subunits alpha 2/delta antibody
    • L type calcium channel subunit alpha 2 antibody
    • MHS 3 antibody
    • MHS3 antibody
    • Voltage dependent calcium channel subunit alpha 2/delta 1 antibody
    • Voltage gated calcium channel subunit alpha 2/delta 1 antibody
    • Voltage-dependent calcium channel subunit delta-1 antibody
    • Voltage-gated calcium channel subunit alpha-2/delta-1 antibody
    see all

Images

  • Immunocytochemistry/ Immunofluorescence of HeLa cells with ab238110 1/200 counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The secondary antibody was Alexa Fluor 488-congugated Goat Anti-Rabbit IgG(H+L).

  • Paraffin-embedded human skeletal muscle tissue stained for Calcium channel L type DHPR alpha 2 subunit/CACNA2D1 with ab238110 at a 1/100 dilution in immunohistochemical analysis.

References

ab238110 has not yet been referenced specifically in any publications.

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