Overview

  • Product name

    Anti-Calcium-independent Phospholipase A2/PLA2G6 antibody
    See all Calcium-independent Phospholipase A2/PLA2G6 primary antibodies
  • Description

    Rabbit polyclonal to Calcium-independent Phospholipase A2/PLA2G6
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WBmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Mouse, Rat, Rabbit
  • Immunogen

    Recombinant fragment corresponding to Human Calcium-independent Phospholipase A2/PLA2G6 aa 399-664.

  • Positive control

    • U87-MG whole cell lysate
  • General notes

     This product was previously labelled as Calcium-independent Phospholipase A2

     

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • Storage buffer

    pH: 7.00
    Preservative: 0.01% Thimerosal (merthiolate)
    Constituents: 1.21% Tris, 0.75% Glycine, 20% Glycerol
  • Concentration information loading...
  • Purity

    Immunogen affinity purified
  • Clonality

    Polyclonal
  • Isotype

    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab126248 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 90 kDa.

Target

  • Function

    Catalyzes the release of fatty acids from phospholipids. It has been implicated in normal phospholipid remodeling, nitric oxide-induced or vasopressin-induced arachidonic acid release and in leukotriene and prostaglandin production. May participate in fas mediated apoptosis and in regulating transmembrane ion flux in glucose-stimulated B-cells. Has a role in cardiolipin (CL) deacylation. Required for both speed and directionality of monocyte MCP1/CCL2-induced chemotaxis through regulation of F-actin polymerization at the pseudopods.
    Isoform ankyrin-iPLA2-1 and isoform ankyrin-iPLA2-2, which lack the catalytic domain, are probably involved in the negative regulation of iPLA2 activity.
  • Tissue specificity

    Four different transcripts were found to be expressed in a distinct tissue distribution.
  • Involvement in disease

    Neurodegeneration with brain iron accumulation 2B
    Neurodegeneration with brain iron accumulation 2A
    Parkinson disease 14
  • Sequence similarities

    Contains 7 ANK repeats.
    Contains 1 patatin domain.
  • Cellular localization

    Cytoplasm and Membrane. Recruited to the membrane-enriched pseudopod upon MCP1/CCL2 stimulation in monocytes.
  • Information by UniProt
  • Database links

  • Form

    The isoform LH-iPLA2 is located at the membrane. The isoform SH-iPLA2 is cytoplasmic.
  • Alternative names

    • 85 kDa calcium independent phospholipase A2 antibody
    • 85/88 kDa calcium-independent phospholipase A2 antibody
    • BB112799 antibody
    • CaI PLA2 antibody
    • CaI-PLA2 antibody
    • CaIPLA2 antibody
    • Calcium independent phospholipase A2 antibody
    • CTA-228A.2 antibody
    • Cytosolic calcium independent phospholipase A2 antibody
    • EC 3.1.1.4 antibody
    • Group VI phospholipase A2 antibody
    • Group VI, A antibody
    • GVI antibody
    • GVI PLA2 antibody
    • INAD1 antibody
    • Intracellular membrane associated calcium independent phospholipase A2 beta antibody
    • Intracellular membrane-associated calcium-independent phospholipase A2 beta antibody
    • iPLA(2)beta antibody
    • iPLA2 beta antibody
    • iPLA2-beta antibody
    • IPLA2-VIA antibody
    • iPLA2beta antibody
    • NBIA2 antibody
    • NBIA2A antibody
    • NBIA2B antibody
    • Neurodegeneration with brain iron accumulation 2 antibody
    • OTTHUMP00000199457 antibody
    • PARK14 antibody
    • Patatin like phospholipase domain containing 9 antibody
    • Patatin like phospholipase domain containing protein 9 antibody
    • Patatin-like phospholipase domain-containing protein 9 antibody
    • Phospholipase A2 calcium independent antibody
    • Phospholipase A2 calcium independent group VI A antibody
    • Phospholipase A2 group VI antibody
    • Phospholipase A2 group VI cytosolic calcium independent antibody
    • Phospholipase A2, group VI (cytosolic, calcium independent) antibody
    • PLA2 antibody
    • PLA2G6 antibody
    • PLPL9_HUMAN antibody
    • PNPLA9 antibody
    see all

Images

  • Anti-Calcium-independent Phospholipase A2/PLA2G6 antibody (ab126248) at 1/500 dilution + U87-MG whole cell lysate at 30 µg

    Predicted band size: 90 kDa



    7.5% SDS-PAGE

References

ab126248 has not yet been referenced specifically in any publications.

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