Anti-Calcium-independent Phospholipase A2/PLA2G6 antibody (ab126248)
Key features and details
- Rabbit polyclonal to Calcium-independent Phospholipase A2/PLA2G6
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
Overview
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Product name
Anti-Calcium-independent Phospholipase A2/PLA2G6 antibody
See all Calcium-independent Phospholipase A2/PLA2G6 primary antibodies -
Description
Rabbit polyclonal to Calcium-independent Phospholipase A2/PLA2G6 -
Host species
Rabbit -
Tested applications
Suitable for: WBmore details -
Species reactivity
Reacts with: Human
Predicted to work with: Mouse, Rat, Rabbit -
Immunogen
Recombinant fragment corresponding to Human Calcium-independent Phospholipase A2/PLA2G6 aa 399-664.
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Positive control
- U87-MG whole cell lysate
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
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Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
Storage buffer
pH: 7.00
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 1.21% Tris, 0.75% Glycine, 20% Glycerol (glycerin, glycerine) -
Concentration information loading...
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Purity
Immunogen affinity purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab126248 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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WB |
1/500 - 1/3000. Predicted molecular weight: 90 kDa.
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Notes |
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WB
1/500 - 1/3000. Predicted molecular weight: 90 kDa. |
Target
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Function
Catalyzes the release of fatty acids from phospholipids. It has been implicated in normal phospholipid remodeling, nitric oxide-induced or vasopressin-induced arachidonic acid release and in leukotriene and prostaglandin production. May participate in fas mediated apoptosis and in regulating transmembrane ion flux in glucose-stimulated B-cells. Has a role in cardiolipin (CL) deacylation. Required for both speed and directionality of monocyte MCP1/CCL2-induced chemotaxis through regulation of F-actin polymerization at the pseudopods.
Isoform ankyrin-iPLA2-1 and isoform ankyrin-iPLA2-2, which lack the catalytic domain, are probably involved in the negative regulation of iPLA2 activity. -
Tissue specificity
Four different transcripts were found to be expressed in a distinct tissue distribution. -
Involvement in disease
Neurodegeneration with brain iron accumulation 2B
Neurodegeneration with brain iron accumulation 2A
Parkinson disease 14 -
Sequence similarities
Contains 7 ANK repeats.
Contains 1 patatin domain. -
Cellular localization
Cytoplasm and Membrane. Recruited to the membrane-enriched pseudopod upon MCP1/CCL2 stimulation in monocytes. - Information by UniProt
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Database links
- Entrez Gene: 8398 Human
- Entrez Gene: 53357 Mouse
- Entrez Gene: 360426 Rat
- Omim: 603604 Human
- SwissProt: O60733 Human
- SwissProt: P97819 Mouse
- SwissProt: P97570 Rat
- Unigene: 170479 Human
see all -
Form
The isoform LH-iPLA2 is located at the membrane. The isoform SH-iPLA2 is cytoplasmic. -
Alternative names
- 85 kDa calcium independent phospholipase A2 antibody
- 85/88 kDa calcium-independent phospholipase A2 antibody
- BB112799 antibody
see all
Images
Datasheets and documents
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SDS download
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Datasheet download
References (0)
ab126248 has not yet been referenced specifically in any publications.