Anti-CALHM1 antibody (ab106561)
Key features and details
- Rabbit polyclonal to CALHM1
- Suitable for: ICC/IF, WB, IHC-P
- Reacts with: Mouse, Rat, Human
- Isotype: IgG
Overview
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Product name
Anti-CALHM1 antibody -
Description
Rabbit polyclonal to CALHM1 -
Host species
Rabbit -
Specificity
This antibody is predicted to not crossreact with CALHM2 or CALHM3. -
Tested applications
Suitable for: ICC/IF, WB, IHC-Pmore details -
Species reactivity
Reacts with: Mouse, Rat, Human -
Immunogen
Synthetic peptide corresponding to 17 amino acids near the amino terminus of Human CALHM1 (NP_001001412).
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Positive control
- Rat liver tissue lysate; Rat liver tissue
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General notes
Reproducibility is key to advancing scientific discovery and accelerating scientists’ next breakthrough.
Abcam is leading the way with our range of recombinant antibodies, knockout-validated antibodies and knockout cell lines, all of which support improved reproducibility.
We are also planning to innovate the way in which we present recommended applications and species on our product datasheets, so that only applications & species that have been tested in our own labs, our suppliers or by selected trusted collaborators are covered by our Abpromise™ guarantee.
In preparation for this, we have started to update the applications & species that this product is Abpromise guaranteed for.
We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.
Applications & species from publications and Abreviews that have not been tested in our own labs or in those of our suppliers are not covered by the Abpromise guarantee.
Please check that this product meets your needs before purchasing. If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, as well as customer reviews and Q&As.
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at 4°C (stable for up to 12 months). -
Storage buffer
pH: 7.2
Preservative: 0.02% Sodium azide
Constituent: PBS -
Concentration information loading... -
Purity
Immunogen affinity purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
Applications
Our Abpromise guarantee covers the use of ab106561 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| Application | Abreviews | Notes |
|---|---|---|
| ICC/IF | Use a concentration of 20 µg/ml. | |
| WB | Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 38 kDa. | |
| IHC-P | Use a concentration of 5 µg/ml. |
Target
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Function
May be a pore-forming ion channel. Controls cytosolic Ca(2+) permeability and cytosolic Ca(2+) concentration. Controls amyloid precursor protein (APP) proteolysis and aggregated amyloid-beta (Abeta) peptides levels in a Ca(2+) dependent manner. -
Tissue specificity
Predominantly expressed in adult brain. Detected also in retinoic acid-differentiated SH-SY5Y cells. -
Sequence similarities
Belongs to the FAM26 family. -
Cellular localization
Cell membrane. Endoplasmic reticulum membrane. Colocalizes with HSPA5 at the endoplasmic reticulum. - Information by UniProt
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Database links
- Entrez Gene: 255022 Human
- Entrez Gene: 546729 Mouse
- Entrez Gene: 499367 Rat
- Omim: 612234 Human
- SwissProt: Q8IU99 Human
- Unigene: 680365 Human
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Alternative names
- CAHM1_HUMAN antibody
- Calcium homeostasis modulator 1 antibody
- Calcium homeostasis modulator protein 1 antibody
see all
Images
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Western blot - Anti-CALHM1 antibody (ab106561)Lane 1 : Anti-CALHM1 antibody (ab106561) at 1 µg/ml
Lane 2 : Anti-CALHM1 antibody (ab106561) at 2 µg/ml
All lanes : Rat liver tissue lysate
Lysates/proteins at 15 µg per lane.
Predicted band size: 38 kDa -
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CALHM1 antibody (ab106561)Immunohistochemical analysis of CALHM1 in paraffin embedded Rat liver tissue, using ab106561 at 5 µg/ml. -
Immunocytochemistry/ Immunofluorescence - Anti-CALHM1 antibody (ab106561)Immunofluorescence of CALHM1 in Rat Liver cells using ab106561 at 20 ug/ml.
Protocols
Datasheets and documents
References (0)
ab106561 has not yet been referenced specifically in any publications.
