Overview

  • Product name
    Anti-CALHM1 antibody
    See all CALHM1 primary antibodies
  • Description
    Rabbit polyclonal to CALHM1
  • Host species
    Rabbit
  • Specificity
    This antibody is predicted to not crossreact with CALHM2 or CALHM3.
  • Tested applications
    Suitable for: ICC/IF, WB, IHC-Pmore details
  • Species reactivity
    Reacts with: Mouse, Rat, Human
  • Immunogen

    Synthetic peptide corresponding to 17 amino acids near the amino terminus of Human CALHM1 (NP_001001412).

  • Positive control
    • Rat liver tissue lysate; Rat liver tissue

Properties

Applications

Our Abpromise guarantee covers the use of ab106561 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ICC/IF Use a concentration of 20 µg/ml.
WB Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 38 kDa.
IHC-P Use a concentration of 5 µg/ml.

Target

  • Function
    May be a pore-forming ion channel. Controls cytosolic Ca(2+) permeability and cytosolic Ca(2+) concentration. Controls amyloid precursor protein (APP) proteolysis and aggregated amyloid-beta (Abeta) peptides levels in a Ca(2+) dependent manner.
  • Tissue specificity
    Predominantly expressed in adult brain. Detected also in retinoic acid-differentiated SH-SY5Y cells.
  • Sequence similarities
    Belongs to the FAM26 family.
  • Cellular localization
    Cell membrane. Endoplasmic reticulum membrane. Colocalizes with HSPA5 at the endoplasmic reticulum.
  • Information by UniProt
  • Database links
    • Alternative names
      • CAHM1_HUMAN antibody
      • Calcium homeostasis modulator 1 antibody
      • Calcium homeostasis modulator protein 1 antibody
      • CALHM1 antibody
      • FAM26C antibody
      • Family with sequence similarity 26, member C antibody
      • MGC39514 antibody
      • MGC39617 antibody
      • OTTHUMP00000020413 antibody
      • Protein FAM26C antibody
      see all

    Images

    • Western blot - Anti-CALHM1 antibody (ab106561)
      Western blot - Anti-CALHM1 antibody (ab106561)
      Lane 1 : Anti-CALHM1 antibody (ab106561) at 1 µg/ml
      Lane 2 : Anti-CALHM1 antibody (ab106561) at 2 µg/ml

      All lanes : Rat liver tissue lysate

      Lysates/proteins at 15 µg per lane.

      Predicted band size: 38 kDa

    • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CALHM1 antibody (ab106561)
      Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CALHM1 antibody (ab106561)
      Immunohistochemical analysis of CALHM1 in paraffin embedded Rat liver tissue, using ab106561 at 5 µg/ml.
    • Immunocytochemistry/ Immunofluorescence - Anti-CALHM1 antibody (ab106561)
      Immunocytochemistry/ Immunofluorescence - Anti-CALHM1 antibody (ab106561)
      Immunofluorescence of CALHM1 in Rat Liver cells using ab106561 at 20 ug/ml.

    References

    ab106561 has not yet been referenced specifically in any publications.

    Publishing research using ab106561? Please let us know so that we can cite the reference in this datasheet.

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