Overview

  • Product name
    Anti-Calpain 4 antibody
  • Description
    Rabbit polyclonal to Calpain 4
  • Host species
    Rabbit
  • Tested applications
    Suitable for: IHC-Pmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide within Human Calpain 4 aa 50-150 (internal sequence). The exact sequence is proprietary.
    Database link: P04632

  • Positive control
    • Human breast tissue

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
  • Storage buffer
    Preservative: 0.1% Sodium Azide
    Constituents: BSA, 10mM PBS, pH 7.4
  • Concentration information loading...
  • Purity
    Immunogen affinity purified
  • Clonality
    Polyclonal
  • Isotype
    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab93959 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/100. Perform heat mediated antigen retrieval before commencing with IHC staining protocol.

Target

  • Relevance
    Calpains are a ubiquitous, well-conserved family of calcium-dependent, cysteine proteases. Calpain families have been implicated in neurodegenerative processes, as their activation can be triggered by calcium influx and oxidative stress. Calpain I and II are heterodimeric with distinct large subunits associated with common small subunits, all of which are encoded by different genes.Calpain 4 is a small subunit common to both calpain I and II and is associated with myotonic dystrophy.
  • Cellular localization
    Cytoplasm. Cell membrane. Note: Translocates to the plasma membrane upon calcium binding
  • Database links
  • Alternative names
    • 30K antibody
    • Calcium activated neutral proteinase antibody
    • Calcium activated neutral proteinase small subunit antibody
    • Calcium dependent protease small subunit 1 antibody
    • Calcium dependent protease small subunit antibody
    • Calpain 4 small subunit (30K) antibody
    • Calpain regulatory subunit antibody
    • Calpain small polypeptide antibody
    • Calpain small subunit 1 antibody
    • Calpain4 antibody
    • CANP antibody
    • CANP small subunit antibody
    • CANPS antibody
    • CAPN4 antibody
    • CAPNS 1 antibody
    • CAPNS1 antibody
    • CDPS antibody
    • CSS1 antibody
    see all

Images

  • ab93959 at 1/100 dilution, staining Calpain 4 in formalin-fixed, paraffin-embedded Human breast tissue.

References

This product has been referenced in:
  • Liu T  et al. Calpastatin is regulated by protein never in mitosis gene A interacting-1 (PIN1) in endothelial cells. Biochem Biophys Res Commun 414:581-6 (2011). Read more (PubMed: 21982763) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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