Overview

  • Product name

    Calphostin C, PKC inhibitor
  • Description

    Potent, selective PKC inhibitor
  • Biological description

    Potent protein kinase C inhibitor (IC50 values are 50 and >1000 nM for PKC and PKA respectively). Cell permeable. Active in vivo and in vitro. Inhibits phorbol dibutyrate binding to PKC.
  • Purity

    > 95%
  • CAS Number

    121263-19-2
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    1-[3,10-Dihydroxy-12-[2-(4-hydroxyphenoxy)carbonyloxypropyl]-2,6,7,11-tetramethoxy-4,9-dioxoperylen-1-yl]propan-2-yl benzoate

  • Molecular weight

    790.76
  • Molecular formula

    C44H38O14
  • PubChem identifier

    2533
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO

  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CC(CC1=C(C(=C2C(=O)C=C(C3=C4C(=CC(=O)C5=C(C(=C(C(=C45)C1=C32)CC(C)OC(=O)OC6=CC=C(C=C6)O)OC)O)OC)OC)O)OC)OC(=O)C7=CC=CC=C7
  • Source

    Cladosporium cladosporioides

  • Research areas

Associated products

References

This product has been referenced in:

  • Chiarini A  et al. Calphostin C, a remarkable multimodal photodynamic killer of neoplastic cells by selective nuclear lamin B1 destruction and apoptogenesis (Review). Oncol Rep 23:887-92 (2010). Read more (PubMed: 20204270) »
  • Ghosh AK Regulation by prostaglandin E2 and histamine of angiogenesis in inflammatory granulation tissue. Yakugaku Zasshi 123:295-303 (2003). Read more (PubMed: 12772586) »
  • Ziyadeh FN  et al. Role of protein kinase C and cyclic AMP/protein kinase A in high glucose-stimulated transcriptional activation of collagen alpha 1 (IV) in glomerular mesangial cells. J Diabetes Complications 9:255-61 (0). Read more (PubMed: 8573741) »

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