Overview

  • Product name

    Anti-Calreticulin 3 antibody
    See all Calreticulin 3 primary antibodies
  • Description

    Rabbit polyclonal to Calreticulin 3
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WBmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Mouse, Rat, Cow
  • Immunogen

    Recombinant fragment within Human Calreticulin 3 (internal sequence). The exact sequence is proprietary.
    Database link: Q96L12

  • Positive control

    • WB: U-87 MG whole cell lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab227621 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 45 kDa.

Target

  • Function

    During spermatogenesis, may act as a lectin-independent chaperone for specific client proteins such as ADAM3. Required for sperm fertility (By similarity). CALR3 capacity for calcium-binding may be absent or much lower than that of CALR.
  • Tissue specificity

    Testis specific.
  • Involvement in disease

    Defects in CALR3 are the cause of familial hypertrophic cardiomyopathy type 19 (CMH19) [MIM:613875]. CMH19 is a hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death.
  • Sequence similarities

    Belongs to the calreticulin family.
  • Domain

    Can be divided into a N-terminal globular domain, a proline-rich P-domain forming an elongated arm-like structure and a C-terminal acidic domain. The P-domain binds one molecule of calcium with high affinity, whereas the acidic C-domain binds multiple calcium ions with low affinity.
    The interaction with glycans occurs through a binding site in the globular lectin domain.
    The zinc binding sites are localized to the N-domain.
  • Cellular localization

    Endoplasmic reticulum lumen.
  • Information by UniProt
  • Database links

  • Alternative names

    • CALR 3 antibody
    • CALR3 antibody
    • CALR3_HUMAN antibody
    • Calreticulin 2 antibody
    • Calreticulin-2 antibody
    • Calreticulin-3 antibody
    • Calreticulin2 antibody
    • Calreticulin3 antibody
    • Calsperin antibody
    • Cancer/testis antigen 93 antibody
    • CMH19 antibody
    • CRT2 antibody
    • CT93 antibody
    • FLJ25355 antibody
    • MGC26577 antibody
    see all

Images

  • Anti-Calreticulin 3 antibody (ab227621) at 1/1000 dilution + U-87 MG (human glioblastoma-astrocytoma epithelial cell line) whole cell lysate at 30 µg

    Predicted band size: 45 kDa



    10% SDS-PAGE gel.

References

ab227621 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

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