Overview

  • Product name

    Anti-Calsequestrin 1 antibody
    See all Calsequestrin 1 primary antibodies
  • Description

    Rabbit polyclonal to Calsequestrin 1
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WBmore details
  • Species reactivity

    Reacts with: Mouse, Human
  • Immunogen

    Recombinant fragment, corresponding to a region within amino acids 136-341 of Human Calsequestrin 1 (P31415).

  • Positive control

    • A549, HeLa, HepG2, HCT116 and Mouse heart whole cell lysates.

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • Storage buffer

    pH: 7.00
    Preservative: 0.025% Proclin
    Constituents: PBS, 1% BSA, 20% Glycerol
  • Concentration information loading...
  • Purity

    Immunogen affinity purified
  • Clonality

    Polyclonal
  • Isotype

    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab126241 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 44 kDa.

Target

  • Function

    Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle. The release of calcium bound to calsequestrin through a calcium release channel triggers muscle contraction. Binds 40 to 50 moles of calcium. Also binds laminin.
  • Sequence similarities

    Belongs to the calsequestrin family.
  • Cellular localization

    Sarcoplasmic reticulum lumen. Mitochondrion. This isoform of calsequestrin occurs in the sarcoplasmic reticulum's terminal cisternae luminal spaces of fast skeletal muscle cells. Also mitochondrial according to PubMed:7945294.
  • Information by UniProt
  • Database links

  • Alternative names

    • Calmitin antibody
    • Calmitine antibody
    • Calsequestrin 1 (fast twitch, skeletal muscle) antibody
    • Calsequestrin antibody
    • Calsequestrin, cell antibody
    • Calsequestrin, skeletal muscle isoform antibody
    • Calsequestrin-1 antibody
    • CASQ antibody
    • Casq1 antibody
    • CASQ1_HUMAN antibody
    • PDIB1 antibody
    • skeletal muscle isoform antibody
    see all

Images

  • Anti-Calsequestrin 1 antibody (ab126241) at 1/1000 dilution + HepG2 whole cell lysate at 30 µg

    Predicted band size: 44 kDa



    10% SDS PAGE
  • Anti-Calsequestrin 1 antibody (ab126241) at 1/1000 dilution + Mouse heart whole cell lysate at 50 µg

    Predicted band size: 44 kDa



    10% SDS PAGE

References

This product has been referenced in:

  • Róg J  et al. Dystrophic mdx mouse myoblasts exhibit elevated ATP/UTP-evoked metabotropic purinergic responses and alterations in calcium signalling. Biochim Biophys Acta Mol Basis Dis N/A:N/A (2019). Read more (PubMed: 30684640) »
See 1 Publication for this product

Customer reviews and Q&As

Answer

Thank you for your enquiry.

I regret to inform you that the originator of this antibody no longer has sufficient stocks for us to be able to make this product available to our customers. We have therefore been forced to withdraw abab126241 from our product range. I do hope that this does not cause you too much inconvenience.

Unfortunately, the majority of the antibodies Calsequestrin recognize skeletal and cardiac Calsequestrin. If the product names indicateCalsequestrin 2 then it recognize the 2 form.

If you need anything further or any help then please let me know.

Read More

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