Anti-CAMK2A + CAMK2B + CAMK2D antibody (ab110881)
- Datasheet
- References
- Protocols
Overview
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Product name
Anti-CAMK2A + CAMK2B + CAMK2D antibody -
Description
Rabbit polyclonal to CAMK2A + CAMK2B + CAMK2D -
Host species
Rabbit -
Tested applications
Suitable for: IHC-Pmore details -
Species reactivity
Reacts with: Human
Predicted to work with: Mouse, Rat -
Immunogen
Synthetic peptide derived from an internal region of Human CAMK2A + CAMK2B + CAMK2D.
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Positive control
- Human brain tissue
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C. -
Storage buffer
pH: 7.40
Preservative: 0.02% Sodium azide
Constituents: PBS, 0.88% Sodium chloride, 50% Glycerol -
Concentration information loading...
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Purity
Immunogen affinity purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
Applications
Our Abpromise guarantee covers the use of ab110881 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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IHC-P | 1/50 - 1/100. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. |
Target
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Relevance
Ca2+/Calmodulin Dependent Protein Kinase II (CaM Kinase II) is a multifunctional calcium and calmodulindependent protein kinase that mediates cellular responses to a wide variety of intercellular signals. CaM Kinase II has been shown to regulate diverse cellular functions including synaptic plasticity, neurotransmitter synthesis and release, gene expression, ion channel function, carbohydrate metabolism, cytoskeletal function, and Ca2+homeostasis. Phosphorylation of Thr286 on the kinase produces an autonomously active form of CaM Kinase II. Autophosphorylation of Thr305 inhibits the activity CaM Kinase II. Phosphorylation at this site appears to reduce the association of CaM Kinase II with the PSD and reduce LTP and learning. -
Database links
- Entrez Gene: 815 Human
- Entrez Gene: 816 Human
- Entrez Gene: 817 Human
- Entrez Gene: 108058 Mouse
- Entrez Gene: 12322 Mouse
- Entrez Gene: 12323 Mouse
- Entrez Gene: 24245 Rat
- Entrez Gene: 24246 Rat
see all -
Alternative names
- Calcium/calmodulin-dependent protein kinase type II subunit alpha antibody
- Calcium/calmodulin-dependent protein kinase type II subunit delta antibody
- CaM kinase II subunit alpha antibody
see all
Images
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CAMK2A + CAMK2B + CAMK2D antibody (ab110881)ab110881, at a 1/50 dilution, staining CAMK2A + CAMK2B + CAMK2D in paraffin-embedded Human brain tissue by Immunohistochemistry, in the absence (left panel) or presence (right panel) of the immunizing peptide.
Protocols
References
ab110881 has not yet been referenced specifically in any publications.